A5103003149- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Lanthanide and Transition Metal Complexes
- Medical Imaging Techniques and Applications
- Endometrial and Cervical Cancer Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Radiation Dose and Imaging
- Ovarian cancer diagnosis and treatment
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Disease and Adiposity
- Prostate Cancer Diagnosis and Treatment
- Photoacoustic and Ultrasonic Imaging
- AI in cancer detection
- MicroRNA in disease regulation
- Ultrasound and Hyperthermia Applications
- Cardiac Imaging and Diagnostics
- Colorectal Cancer Surgical Treatments
- Radiopharmaceutical Chemistry and Applications
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Brain Tumor Detection and Classification
- Endometriosis Research and Treatment
Dalian Medical University
2016-2025
First Affiliated Hospital of Dalian Medical University
2016-2025
Yangzhou University
2021-2024
Yunnan Provincial Science and Technology Department
2022
Kunming University of Science and Technology
2022
Shandong First Medical University
2019
Shandong University
2019
Hebei University of Engineering
2019
Shandong Provincial QianFoShan Hospital
2019
GlaxoSmithKline (China)
2010-2017
T cell activation and function are critically regulated by positive negative costimulatory molecules. Aberrant expression of molecules have been associated with persistent self-reactive cells in autoimmune diseases such as rheumatoid arthritis (RA). In this study, initial analysis led to the unexpected observation that, addition CD80, several regulators (e.g., CTLA-4, programmed death-1 (PD-1), PD ligand-1) were overexpressed synovial macrophages derived from RA patients opposed controls....
To evaluate the feasibility of using radiomics with precontrast magnetic resonance imaging for classifying hepatocellular carcinoma (HCC) and hepatic haemangioma (HH). This study enrolled 369 consecutive patients 446 lesions (a total 222 HCCs 224 HHs). A training set was constituted by randomly selecting 80% samples remaining were used to test. On (MR) images HCC HH obtained in-phase, out-phase, T2-weighted (T2WI), diffusion-weighted (DWI) sequences, we outlined target extracted 1029...
Purpose: To investigate the value of radiomics analysis iodine-based material decomposition (MD) images with dual energy computed tomography (DECT) imaging for preoperatively predicting microsatellite instability (MSI) status in colorectal cancer (CRC). Methods: This study included 102 CRC patients proved by postoperative pathology, and their MSI was confirmed immunohistochemistry staining. All underwent preoperative DECT scanned on either a Revolution CT or Discovery 750HD scanner, MD...
Background Preoperative prediction of early recurrence (ER) hepatocellular carcinoma (HCC) plays a critical role in individualized risk stratification and further treatment guidance. Purpose To investigate the radiomics analysis based on multiparametric MRI (mpMRI) for predicting ER HCC after partial hepatectomy. Study Type Retrospective. Population In all, 113 patients (ER, n = 58 vs. non‐ER, 55), divided into training ( 78) validation 35) cohorts. Field Strength/Sequence 1.5T or 3.0T,...
Purpose To explore the association between type 2 diabetes mellitus (T2DM) and body composition based on magnetic resonance fat fraction (FF) mapping. Methods A total of 341 subjects, who underwent abdominal MRI examination with FF mapping were enrolled in this study, including 68 T2DM patients 273 non-T2DM patients. The FFs areas visceral adipose tissue (VAT), subcutaneous (SAT) muscle (AM) measured at level L1-L2 vertebral. bone marrow (BMAT) was determined by averaged values T12 L1...
Abstract Ethyl 2-[4-(12-β-artemisininoxy)]phenoxylpropionate (SM933) is a novel derivative of artemisinin, an herbal compound approved for the treatment malaria. In this study, we show that SM933 has unique anti-inflammatory properties through regulation signaling pathways, leading to amelioration experimental autoimmune encephalomyelitis. The were characterized by inhibition encephalitogenic T cell responses altered exhibit Th2 immune deviation and reduced activity concentration NO...
The cuprizone model is a well-established and investigated paradigm to study demyelination remyelination in rodents. Cuprizone usually administrated by mixing the powdered or pelleted rodent chow. However, since sensitive environment consumption of it varies between different animals, major issue discrepancy animals. This reports development gavage administrations mice. Following testing series doses cuprizone, 400 mg/kg/day was found be best dosage induce dramatic consistent after 5 weeks...
Background Agents promoting oligodendrocyte precursor cell differentiation have the potential to restore halted and/or delayed remyelination in patients with multiple sclerosis. However, few therapeutic targets been identified. The objective of this study was identify novel for promotion and characterize their activity vitro vivo. Methods A high-content screening assay primary rat cells used screen GSK-proprietary annotated libraries remyelination-promoting compounds. Compounds were further...
Abstract Background Pure ground-glass nodules (pGGNs) with pleural contact (P-pGGNs) comprise not only invasive adenocarcinoma (IAC), but also minimally (MIA). Radiomics recognizes complex patterns in imaging data by extracting high-throughput features of intra-tumor heterogeneity a non-invasive manner. In this study, we sought to develop and validate radiomics signature identify IAC MIA presented as P-pGGNs. Methods total, 100 patients P-pGGNs (69 training samples 31 testing samples) were...
This research was supported by key projects of the Hunan provincial department education (22A0504); and development programme science technology (2022WK2020); foundation for province (21C1122); general project Science Technology Department (2021JJ30061).
To quantitatively analyze renal sinus fat (RSF) dysfunction in type 2 diabetes mellitus (T2DM) patients using magnetic resonance imaging (MRI) fraction (FF) and R2* mapping. The inpatients who underwent 1.5 T MRI examination (including FF mapping) of the abdomen from January 2017 to December 2023 were enrolled. RSF volume, right left kidneys mean values measured. Associations between value T2DM assessed with logistic regression. Receiver operating characteristic (ROC) curve was applied...
The absence of endothelial cells at the luminal surface a prosthetic vascular graft potentiates thrombosis and neointimal hyperplasia, which are common causes failure in humans. This study tested hypothesis that pretreatment with chronic vitro shear stress enhances subsequent cell retention on grafts implanted vivo.Cultured derived from Fischer 344 rat aorta were seeded onto 1.5-mm internal diameter polyurethane grafts. treated for 3 days 1 dyne/cm2 then an additional or 25 vitro. as aortic...