A5007420011- Cardiovascular Function and Risk Factors
- Force Microscopy Techniques and Applications
- Cardiac Imaging and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Lipid Membrane Structure and Behavior
- Radiomics and Machine Learning in Medical Imaging
- Mechanical and Optical Resonators
- Neurofibromatosis and Schwannoma Cases
- RNA and protein synthesis mechanisms
- Cardiac Valve Diseases and Treatments
- Protein Structure and Dynamics
- Advanced MRI Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Advanced Electron Microscopy Techniques and Applications
- Advancements in Battery Materials
- Ion channel regulation and function
- Chemical and Physical Studies
- Advanced battery technologies research
- Advanced Battery Materials and Technologies
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Sarcoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
Sichuan University
2023-2025
First Hospital of Jilin University
2020-2025
Jilin University
2020-2025
Cornell University
2021-2025
Weill Cornell Medicine
2021-2025
West China Hospital of Sichuan University
2023-2024
University of Science and Technology of China
2023
Beijing University of Chemical Technology
2023
Chinese Academy of Sciences
2023
First Affiliated Hospital of Dalian Medical University
2021-2022
Abstract The cycle stability of manganese‐based oxides cathode for sodium‐ion supercapacitor is impeded by severe structural collapse due to the Jahn–Teller (J–T) distortion [MnO 6 ] octahedra as Mn 4+ reduced 3+ . Herein, MnO 2 stabilized Mg 2+ ions confinement between transition metal slabs. induces transformation from original cubic compressed configuration (com‐MnO ), resulting in elimination 3d orbital degeneracy, thereby alleviating deformation [Mn O suppressing J–T during reduction As...
Ischemia with nonobstructive coronary arteries (INOCA) has high morbidity, mortality, and poor quality of life. Metabolic syndrome (MetS) is a complex multiple cardiac metabolic risk factors, significantly increasing the major adverse cardiovascular events in INOCA patients. The study aimed to investigate aggravating effect MetS on left ventricular (LV) deformation function impairment This collected 104 patients (INOCA [MetS−]: n = 56; [MetS+]: 48) 41 sex- age-matched controls. LV function,...
The plasma membrane's main constituents, i.e., phospholipids and membrane proteins, are known to be organized in lipid-protein functional domains supercomplexes. No active membrane-intrinsic process is establish organization. Thus, the interplay of thermal fluctuations biophysical determinants membrane-mediated protein interactions must considered understand Here, we used high-speed atomic force microscopy kinetic elastic theory investigate behavior a model oligomerization assembly...
Abstract Background SIRPB1 expression is upregulated in various tumor types, including gliomas, and known to contribute progression; nevertheless, its function the immune milieu of gliomas still mainly unknown. Methods This study, we analyzed 1152 normal samples from GTEx database 670 glioma TCGA investigate relationship between clinicopathological features. Moreover, gene knockout THP-1 cell lines were constructed using CRISPR/Cas9 induced into a co-culture macrophages cells vitro learn...
Abstract Background Pure ground-glass nodules (pGGNs) with pleural contact (P-pGGNs) comprise not only invasive adenocarcinoma (IAC), but also minimally (MIA). Radiomics recognizes complex patterns in imaging data by extracting high-throughput features of intra-tumor heterogeneity a non-invasive manner. In this study, we sought to develop and validate radiomics signature identify IAC MIA presented as P-pGGNs. Methods total, 100 patients P-pGGNs (69 training samples 31 testing samples) were...
Cryogenic electron microscopy (cryo-EM), X-ray crystallography, and nuclear magnetic resonance (NMR) contribute structural data that are interchangeable, cross-verifiable, visualizable on common platforms, making them powerful tools for our understanding of protein structures. Unfortunately, atomic force (AFM) has so far failed to interface with these biology methods, despite the recent development localization AFM (LAFM) allows extracting high-resolution information from data. Here, we...
The number of cancer survivors has steadily increased due to earlier detection and more effective therapies. Do all types have an risk developing subsequent cancers compared with the general population? Patients diagnosed malignant between January 2000 December 2021 were included from SEER 17 Registries (excl AK) database. Events defined as at any site according ICD-O-3/WHO 2008. observed expected numbers retrieved, observed/expected (O/E) ratios excess risks calculated assess in United...
Metabolic syndrome (MetS) can increase the risk of morbidity and mortality cardiovascular disease obstructive coronary artery (OCAD), which usually have a poor prognosis. This study aimed to explore impact MetS on left ventricular (LV) deformation function in OCAD patients investigate independent factors impaired LV deformation.
PurposeThis study aimed to develop a model based on radiomics features extracted from computed tomography (CT) images effectively differentiate between minimally invasive adenocarcinomas (MIAs) and (IAs) manifesting as pure ground-glass nodules (pGGNs) larger than 10 mm.MethodThis retrospective included patients who underwent surgical resection for persistent pGGN November 2012 June 2018 diagnosed with MIAs or IAs. The were randomly assigned the training test cohorts. correlation coefficient...
Conformational changes in ion channels lead to gating of an ion-conductive pore. Ion flux has been measured with high temporal resolution by single-channel electrophysiology for decades. However, correlation between functional and conformational dynamics remained difficult, lacking experimental techniques monitor sub-millisecond changes. Here, we use the outer membrane protein G (OmpG) as a model system where loop-6 opens closes β-barrel pore like lid pH-dependent manner. Functionally, shows...
We aimed to analyze the epidemiology and outcomes of pediatric patients adult with optic pathway gliomas in United States using a population-based method.Data for diagnosed between 2000 2018 were extracted from SEER database. divided into group an group. Descriptive analyses conducted demographic clinical characteristics treatment. used chi-square test evaluate differences gliomas. The possible prognostic indicators analyzed by Kaplan-Meier curves Cox proportional hazards models.Optic...
Recognition of DNA by proteins depends on sequence and structure. Often unanswered is whether the structure naked persists in a protein-DNA complex, or protein binding changes shape. While X-ray structures complexes are numerous, cognate seldom available experimentally. We present here an experimental computational analysis pipeline that uses hydroxyl radical cleavage to map, at single-nucleotide resolution, minor groove width, recognition feature widely exploited proteins. For 11 complexes,...
In observational studies, statins have been suggested to protective effects on venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE). To this aim, we performed a two-sample mendelian randomization (MR) analysis determine whether these associations were causal.Data the single nucleotide polymorphisms (SNPs) related statin medication obtained from FinnGen study, data for VTE, PE DVT of lower extremities (LEDVT) UK Biobank respectively. Inverse variance...
The study was designed to assess the effect of co-occurrence diabetes mellitus (DM) and hypertension on deterioration left atrioventricular coupling index (LACI) atrial (LA) function in comparison individuals suffering from DM only.From December 2015 June 2022, we consecutively recruited patients with clinically diagnosed who underwent cardiac magnetic resonance (CMR) at our hospital. comprised a total 176 DM, were divided into two groups based their blood pressure status: 103 (DM + HP) 73...
Background: Primary intracranial Ewing sarcoma (ES)/peripheral primitive neuroectodermal tumors (pPNETs) are extremely rare malignancies, which arise in children and adolescents, with only 9 cases reported patients over 30 years of age. Due to its rarity, MRI features treatment strategies for primary ES/pPNETs remain unclear. The purpose this study was explore the clinical features, imaging findings, pathological characteristics, different diagnoses, treatment, prognosis cerebellar...
Abstract Bcs1, a homo-heptameric transmembrane AAA-ATPase, facilitates folded Rieske iron-sulfur protein translocation across the inner mitochondrial membrane. Structures in different nucleotide states (ATPγS, ADP, apo) provided conformational snapshots, but kinetics and structural transitions of ATPase cycle remain elusive. Here, using high-speed atomic force microscopy (HS-AFM) line scanning (HS-AFM-LS), we characterized single-molecule Bcs1 cycling. While ATP conformation had ~5600 ms...
Abstract Background Pleural deformation is associated with the invasiveness of lung adenocarcinoma(LAC). Our study focused on pathological components area adjacent pleura in pulmonary pure ground-glass nodules(pGGNs) pleural deformations(P-pGGNs) confirmed to be invasive LAC without visceral invasion (VPI) pathologically. Methods Computed tomography(CT) imaging features nodules and were analyzed recorded. Statistical analysis was performed for subgroups P-pGGNs. Results The 81 enrolled...