A5020712237- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Advanced Neuroimaging Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Brain Metastases and Treatment
- Head and Neck Cancer Studies
- Lanthanide and Transition Metal Complexes
- Radiation Therapy and Dosimetry
- Functional Brain Connectivity Studies
- Liver Disease Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Bone and Joint Diseases
- Thyroid Cancer Diagnosis and Treatment
- Migraine and Headache Studies
- Lung Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Endometrial and Cervical Cancer Treatments
- Effects of Radiation Exposure
- Neurobiology of Language and Bilingualism
- Advances in Oncology and Radiotherapy
- Ultrasound and Hyperthermia Applications
University of Michigan
2016-2025
Peking Union Medical College Hospital
2014-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Guangzhou University of Chinese Medicine
2025
Affiliated Hospital of Nantong University
2025
Sichuan Provincial Hospital of Traditional Chinese Medicine
2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Michigan United
2013-2023
Beijing Academy of Artificial Intelligence
2023
Background and Purpose —Studies of cerebral activation motor function after ischemic stroke may enhance our understanding the underlying mechanisms functional recovery, including role noninfarcted hemisphere. Methods —Eight right-handed recovering hemiparetic or hemiplegic patients were studied using MRI. Results evaluated for each patient to consider individual variability in original organization, neuroanatomy, infarct size extent, treatment, age, sex. The results also pooled as a group...
Magnetic resonance (MR) images often provide superior anatomic and functional information over computed tomography (CT) images, but generally are not used alone without CT for radiotherapy treatment planning image guidance. This study aims to investigate the potential of probabilistic classification voxels from multiple MRI contrasts generate synthetic ('MRCT') images. The method consists (1) acquiring volumes: T1-weighted, T2-weighted, two echoes a ultra-short echo time (UTE) sequence,...
Abstract Background N6‐methyladenosine (m 6 A) RNA modification has been demonstrated to be a significant regulatory process in the progression of various tumors, including breast cancer. Fat mass and obesity‐associated (FTO) enzyme, initially known as obesity‐related protein, is first identified m A demethylase. However, relationship between FTO cancer remains controversial. In this study, we aimed elucidate role clinical significance explore underlying mechanism. Methods We investigated...
Vision transformers (ViT) have shown promise in various vision tasks while the U-Net based on a convolutional neural network (CNN) remains dominant diffusion models. We design simple and general ViT-based architecture (named U-ViT) for image generation with U-ViT is characterized by treating all inputs including time, condition noisy patches as tokens employing long skip connections between shallow deep layers. evaluate unconditional classconditional generation, well text-to-image tasks,...
<h3>Background</h3> Spreading depression of Leao has been hypothesized as the basis for visual aura migraine attack, supported by cerebral blood flow measurements spreading hypoperfusion. The early depolarizing or activation phase experimental depression, however, is associated with a transient but pronounced increase that precedes <h3>Objective</h3> To study this we investigated visually triggered attacks headache and symptoms using red-green checkerboard stimulus in patients migraine....
Background and Purpose —Two mechanisms for recovery from aphasia, repair of damaged language networks activation compensatory areas, have been proposed. In this study, we investigated whether both or one instead the other take place in brain recovered aphasic patients . Methods —Using blood oxygenation level–dependent functional MRI (fMRI), studied cortical during lexical-semantic processing tasks 7 right-handed at least 5 months after onset left-hemisphere stroke had regained substantial...
Abstract At present, functional magnetic resonance imaging (fMRI) of cortical language functions favors “silent” task paradigms with no overt speaking, due to severe motion artifacts in MR images induced by vocalization. To the extent that neural substrate silent speaking might differ from this is a problem for understanding spoken language. The present study combined event related fMRI methodology set techniques reduction, detection, and correction further investigate speech compare it...
Germinal centers (GCs) generate high affinity B cell responses that are protective against infection but can produce autoreactive when dysregulated. MicroRNAs (miRNAs) have been implicated in the regulation of GC fate, though role many individual miRNAs remains uncharacterized. Here, we demonstrate within GC, miR-21 promotes T follicular helper (Tfh), regulatory (Tfr), and responses, as well downstream antibody production. Regulation response by requires multiple mechanisms, occurring both...
Background: Certain patterns can induce perceptual illusions/distortions and visual discomfort in most people, headaches patients with migraine, seizures photosensitive epilepsy. Visual stimuli are common triggers for migraine attacks, possibly because of a hyperexcitability the cortex shown migraine. Precision ophthalmic tints (POTs) claimed to reduce distortions prevent some patients. We report an fMRI cortical activation study designed investigate neurological mechanisms beneficial...
To determine the maximum-tolerated dose (MTD) of radiation (RT) with concurrent temozolomide in patients newly diagnosed glioblastoma (GBM), to estimate their progression-free (PFS) and overall survival (OS), assess role (11)C methionine PET (MET-PET) imaging predicting recurrence.Intensity-modulated RT (IMRT) doses 66 81 Gy, assigned by time-to-event continual reassessment method, were delivered over 6 weeks daily (75 mg/m(2)) followed adjuvant cyclic (200 mg/m(2) d1-5 q28d ×6 cycles)....
Purpose To determine the in vitro accuracy, test‐retest repeatability, and interplatform reproducibility of T 1 quantification protocols used for dynamic contrast‐enhanced MRI at 1.5 3 T. Methods A phantom with 14 samples was imaged eight centers a common inversion‐recovery spin‐echo (IR‐SE) protocol variable flip angle (VFA) using seven angles, as well site‐specific (VFA different repetition time, proton density, Look‐Locker inversion recovery). Factors influencing accuracy (deviation from...
This multicenter study evaluated the effect of variations in arterial input function (AIF) determination on pharmacokinetic (PK) analysis dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data using shutter-speed model (SSM). Data acquired from eleven prostate cancer patients were shared among nine centers. Each center used a site-specific method to measure individual AIF each set and submitted results managing center. These AIFs, their reference tissue-adjusted variants,...
Abstract Purpose: In locally advanced p16+ oropharyngeal squamous cell carcinoma (OPSCC), (i) to investigate kinetics of human papillomavirus (HPV) circulating tumor DNA (ctDNA) and association with progression after chemoradiation, (ii) compare the predictive value ctDNA imaging biomarkers MRI FDG-PET. Experimental Design: Serial blood samples were collected from patients AJCC8 stage III OPSCC (n = 34) enrolled on a randomized trial: pretreatment; during chemoradiation at weeks 2, 4, 7;...
Threshold for generation of magnetophosphenes has been reported to be lower in migraine. We compared the threshold eliciting phosphenes by transcranial magnetic stimulation and ability visually trigger headache a select group individuals with migraine without aura normal controls.Transcranial was performed using Cadwell MES-10 stimulator. A circular coil, 9.5 cm diameter, applied occipital scalp (7 above inion). Stimulator intensity increased 10% increments until subjects visual phenomena or...
Background.—Migraineurs with visual aura are highly susceptible to illusions and distortion particularly sensitive a pattern of regularly spaced parallel lines or stripes. Purpose.—To determine whether the high degree susceptibility in migraineurs is associated hyperneurological activity occipital cortex. Methods.—In order investigate any relationships among neuronal activity, spatial frequency square‐wave gratings, self‐described distortion, we investigated psychophysical responses gratings...
For chemotherapy to act synergistically and safely with radiation against high-grade gliomas, drugs must pass the endothelial junctions of blood-tumor barrier (BTB) reach all tumor cells, should not blood-brain (BBB) cause toxicity normal brain. The objective this study was assess BBB/BTB status using magnetic resonance imaging (MRI) during a course radiotherapy gliomas.Sixteen patients grade 3 or 4 supratentorial malignant glioma receiving conformal (RT) underwent contrast-enhanced MRI...
Abstract The cortical regions specialized in speech–language exhibit a left–right asymmetry, e.g., larger size the left auditory cortex and Wernicke's area. possibility of developmental asymmetry axonal fibers interconnecting areas can be investigated by vivo diffusion tensor imaging. Fifteen right‐handed native English speakers showed markedly significant ( P < 0. 0005) relative anisotropy water subinsular white matter, greater on left. Additionally, first principal diffusivity was...
Functional magnetic resonance imaging was used to map the hand sensorimotor area of hemiparetic adolescents and young adults who had suffered unilateral brain damage in perinatal period. Unlike normal subjects, exhibit cortical activation primarily contralateral voluntary finger movements, patients' intact hemispheres were equally activated by ipsilateral movements. Our findings are consistent with previous clinical observations animal experiments which suggest that immature is able...