Christopher H. Chapman

ORCID: 0000-0003-1848-1490
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About
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Research Areas
  • Advanced Neuroimaging Techniques and Applications
  • Head and Neck Cancer Studies
  • MRI in cancer diagnosis
  • Glioma Diagnosis and Treatment
  • Advanced MRI Techniques and Applications
  • Head and Neck Surgical Oncology
  • Endometrial and Cervical Cancer Treatments
  • Brain Metastases and Treatment
  • Radiomics and Machine Learning in Medical Imaging
  • Advanced Radiotherapy Techniques
  • Lung Cancer Diagnosis and Treatment
  • Ovarian cancer diagnosis and treatment
  • Management of metastatic bone disease
  • Seismic Waves and Analysis
  • Medical Imaging Techniques and Applications
  • Seismic Imaging and Inversion Techniques
  • Lung Cancer Treatments and Mutations
  • Cancer Genomics and Diagnostics
  • Endometriosis Research and Treatment
  • Cancer-related cognitive impairment studies
  • Lipoproteins and Cardiovascular Health
  • Salivary Gland Tumors Diagnosis and Treatment
  • Ear and Head Tumors
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Dysphagia Assessment and Management

St. Luke's University Health Network
2024

University of California, San Francisco
2016-2021

VA Ann Arbor Healthcare System
2019-2021

Colorado Permanente Medical Group
2020

Kaiser Permanente
2020

University of Michigan
2011-2019

Washington University in St. Louis
2015

Schlumberger (British Virgin Islands)
2014

Schlumberger (United Kingdom)
2014

Michigan United
2013

Many tomographic interpretations of crosshole seismic traveltimes have approximated the raypaths with straight lines connecting source and receiver. This approximation is valid where velocity does not vary greatly, but in many regions interest variations 10–20 percent or more are observed, causing significant ray curvature. Other work has taken this nonlinear effect into account, there do appear to be cases demonstrated success its application problem. We present here an iterative inversion...

10.1190/1.1442644 article EN Geophysics 1989-02-01

There is little known about how brain white matter structures differ in their response to radiation, which may have implications for radiation-induced neurocognitive impairment. We used diffusion tensor imaging (DTI) examine regional variation changes following chemoradiotherapy.Fourteen patients receiving two or three weeks of whole-brain radiation therapy (RT) ± chemotherapy underwent DTI pre-RT, at end-RT, and one month post-RT. Three indices were measured: fractional anisotropy (FA),...

10.1371/journal.pone.0057768 article EN cc-by PLoS ONE 2013-03-04

The function of noradrenaline in the rat neurohypophysis was investigated by examining effects selective adrenergic receptor agents on electrically evoked release oxytocin, arginine vasopressin, and using [3H]-noradrenaline technique. Since endogenous opioids suppress both neurohormones noradrenaline, we assessed role mediating opioid actions neurohormone secretion modification action antagonist naloxone agents. data suggest (1) that addition to receptors, 'presynaptic' alpha 2-receptors...

10.1159/000124985 article EN Neuroendocrinology 1988-01-01

Purpose : To segment fiber tracts in the limbic circuit and to assess their sensitivity radiation therapy (RT). Methods: Twelve patients with brain metastases who had received fractionated whole 30 Gy or 37.5 were included study. Diffusion weighted images acquired pre‐RT, at end of RT, 1‐month post‐RT. The fornix, corpus callosum, cingulum extracted from diffusion by combining tracking segmentation methods based upon characteristics bundles. Cingulum was segmented a seed‐based tractography,...

10.1118/1.4745560 article EN Medical Physics 2012-08-24

Optimal techniques and patient selection for salvage reirradiation of high-grade glioma (HGG) are unclear. In this study, we identify prognostic factors freedom from progression (FFP) overall survival (OS) after reirradiation, risk toxicity, validate clinical scores.A total 116 patients evaluated between 2000 2018 received HGG (99 WHO grade IV, 17 III). Median time to first initial therapy was 10.6 months. Salvage therapies before included surgery (31%) systemic (41%). Sixty-five (56%)...

10.1093/nop/npz017 article EN Neuro-Oncology Practice 2019-04-12

Wearable devices are increasingly used for health monitoring, yet the impact of consistent wear on physiological and behavioral outcomes is unclear. Leveraging nearly a million days nights longitudinal data from 11,914 subscribers, we examined associations between frequency wearing wrist-worn wearable device (WHOOP Inc., Boston, MA) 12-week changes in biometric, sleep, activity profiles, modeling both within-person effects. Higher average frequency, week-to-week increases wear, were...

10.20944/preprints202503.0931.v1 preprint EN 2025-03-13

This research examines cardiovascular response to everyday threats and challenges during wakefulness sleep. Approximately eleven thousand people, who comprised a diverse sample ethnically but not socioeconomically, completed three weekly morning evening surveys in which they indicated whether expected experienced that day. Participants also provided measures of blood pressure on average heart rate the day resting when asleep via their WHOOP biometric capture device. Enrollment began April,...

10.31234/osf.io/4n7v3_v1 preprint EN 2025-03-22

Purpose Consistently performing at the highest level in golf requires a complex interplay of physiological and psychological attributes, with success often defined by razor-thin margins. Sleep characteristics cardiac autonomic function, reflected resting heart rate (RHR) variability (HRV), are key indicators recovery readiness to perform. Yet, their relevance elite performance remains largely unexplored. Methods We analyzed wearable-derived longitudinal data from 389 professional tour-level...

10.1101/2025.03.31.25324953 preprint EN cc-by-nc medRxiv (Cold Spring Harbor Laboratory) 2025-04-01

Wearable devices are increasingly used for health monitoring, yet the impact of consistent wear on physiological and behavioral outcomes is unclear. Leveraging nearly a million days nights longitudinal data from 11,914 subscribers, we examined associations between frequency wearing wrist-worn wearable device (WHOOP Inc., Boston, MA, USA) 12-week changes in biometric, sleep, activity profiles, modeling both between- within-person effects. Higher average week-to-week increases were associated...

10.3390/s25082437 article EN cc-by Sensors 2025-04-12

The majority of esophageal cancer is either adenocarcinoma (ACA) or squamous cell carcinoma (SCCA). Recent randomized trials suggest that definitive chemoradiotherapy may be equally effective as surgery. However, the responsiveness ACA versus SCCA to radiotherapy (RT) has never been compared. This Surveillance Epidemiology and End Results registry analysis investigates whether survival differed between based on treatment modality.Patients with T2-4N0 N+ in cervical thoracic esophagus...

10.1097/coc.0b013e3181917158 article EN American Journal of Clinical Oncology 2009-05-21

Multiple sclerosis (MS) is a neurological disorder with high burden on patient quality of life and medical rehabilitation services. Little known about the acute hospitalization costs characteristics. We examined trends in MS hospitalizations from 1993 to 2006.The Nationwide Inpatient Sample Healthcare Cost Utilization Project was searched using ICD-9 code 340 (MS). Diagnostic, treatment administrative data were analyzed basic statistical software.A total 288,454 hospital admissions primary...

10.1159/000310301 article EN Neuroepidemiology 2010-01-01

Abstract BACKGROUND: Pancreatic cancer is associated with mutations in the tumor suppressor gene cyclin‐dependent kinase inhibitor 2A (p16 INK4A ), a regulator of cell cycle and apoptosis. This study investigates whether immunohistochemical expression p16 as well hypoxia markers poly adenosine diphosphate‐ribose polymerase (PARP) correlates survival patients resected pancreatic adenocarcinoma. METHODS: Seventy‐three adenocarcinoma who underwent curative resection at Stanford University were...

10.1002/cncr.25481 article EN Cancer 2010-07-21
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