A5060316016- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Effects of Radiation Exposure
- Statistical Methods in Clinical Trials
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Health Systems, Economic Evaluations, Quality of Life
- Advances in Oncology and Radiotherapy
- Radiopharmaceutical Chemistry and Applications
- Radiation Therapy and Dosimetry
- Global Cancer Incidence and Screening
- Pancreatic and Hepatic Oncology Research
- Heat shock proteins research
- Brain Metastases and Treatment
- Radiation Dose and Imaging
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Dysphagia Assessment and Management
University of Michigan–Ann Arbor
2016-2025
VA Ann Arbor Healthcare System
2025
Michigan Medicine
2010-2023
Radiation Oncology Associates
2006-2023
Defence Science and Technology Group
2023
Michigan Cancer Research Consortium
2022
Michigan United
2013-2022
Cancer Research And Biostatistics
2015-2021
Debiopharm (Switzerland)
2019
Ipsen (France)
2019
Data guiding selection of nonsurgical treatment hepatocellular carcinoma (HCC) are lacking. We therefore compared outcomes between stereotactic body radiotherapy (SBRT) and radiofrequency ablation (RFA) for HCC.From 2004 to 2012, 224 patients with inoperable, nonmetastatic HCC underwent RFA (n = 161) 249 tumors or image-guided SBRT 63) 83 tumors. applied inverse probability weighting adjust imbalances in assignment. Freedom from local progression (FFLP) toxicity were retrospectively...
Black men are more likely to die of prostate cancer than white men. In with similar stages disease, the contribution biological vs nonbiological differences this observed disparity is unclear.To quantify association black race long-term survival outcomes after controlling for known prognostic variables and access care among cancer.This multiple-cohort study included updated individual patient-level data clinical T1-4N0-1M0 from following 3 cohorts: Surveillance, Epidemiology, End Results...
Purpose Radiation therapy is a critical component in the care of patients with non-small-cell lung cancer (NSCLC), yet cardiac injury after treatment significant concern. Therefore, we wished to elucidate incidence events and their relationship radiation dose heart. Patients Materials Study eligibility criteria included stage II III NSCLC treated on one four prospective trials at two centers from 2004 2013. All were reviewed graded per Common Terminology Criteria for Adverse Events (v4.03)....
Our previous studies demonstrated that tumors significantly decrease in size and metabolic activity after delivery of 45 Gy fractionated radiatiotherapy (RT), shrinkage is greater than anatomic shrinkage. This study aimed to determine whether 18F-fludeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) acquired during the course treatment provides an opportunity deliver higher-dose radiation more aggressive areas tumor improve local control without increasing RT-induced...
Comparative efficacy research performed using population registries can be subject to significant bias. There is an absence of objective data demonstrating factors that sufficiently reduce bias and provide accurate results.MEDLINE was searched from January 2000 October 2016 for observational studies comparing two treatment regimens any diagnosis cancer, SEER, SEER-Medicare, or the National Cancer Database. Reporting quality statistical methods were assessed components STROBE criteria....
AZD1775 (adavosertib) is an inhibitor of the Wee1 kinase. In this study, we built on our preclinical studies to evaluate safety and efficacy in combination with gemcitabine radiation patients newly diagnosed locally advanced pancreatic cancer.Thirty-four cancer were enrolled intention receive four 21-day cycles (1,000 mg/m2 days 1 8) (once daily 1, 2, 8, 9). Cycles 2 3 administered concurrently radiation, 5 8 optional. was dose escalated using a time-to-event continual reassessment method...
Patients with preexisting liver dysfunction could benefit the most from personalized therapy for tumors to balance maximal tumor control and minimal risk of failure. We designed an individualized adaptive trial testing hypothesis that adapting treatment based on change in function optimize therapeutic index each patient.To characterize safety efficacy stereotactic body radiotherapy (SRBT) patients who have dysfunction.From 2010 2014, 90 intrahepatic cancer treated prior liver-directed were...
To determine the maximum-tolerated dose (MTD) of radiation (RT) with concurrent temozolomide in patients newly diagnosed glioblastoma (GBM), to estimate their progression-free (PFS) and overall survival (OS), assess role (11)C methionine PET (MET-PET) imaging predicting recurrence.Intensity-modulated RT (IMRT) doses 66 81 Gy, assigned by time-to-event continual reassessment method, were delivered over 6 weeks daily (75 mg/m(2)) followed adjuvant cyclic (200 mg/m(2) d1-5 q28d ×6 cycles)....
With the era of big data, utilization machine learning algorithms in radiation oncology is rapidly growing with applications including: treatment response modeling, planning, contouring, organ segmentation, image-guidance, motion tracking, quality assurance, and more. Despite this interest, practical clinical implementation as part day-to-day operations still lagging. The aim white paper to further promote progress new field by highlighting its untapped advantages potentials for advancement,...
<h3>Importance</h3> In men with recurrent prostate cancer, addition of long-term antiandrogen therapy to salvage radiotherapy (SRT) was associated overall survival (OS) in the NRG/RTOG 9601 study. However, hormone has morbidity, and there are no validated predictive biomarkers identify which patients derive most benefit from treatment. <h3>Objective</h3> To examine role pre-SRT prostate-specific antigen (PSA) levels personalize use SRT. <h3>Interventions</h3> Men were randomized SRT plus...