A5067334998- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Advanced MRI Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Gallbladder and Bile Duct Disorders
- Cardiac Imaging and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Hepatitis Viruses Studies and Epidemiology
- Ocular Oncology and Treatments
- Renal and Vascular Pathologies
- Pediatric Urology and Nephrology Studies
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiovascular and Diving-Related Complications
- Radiomics and Machine Learning in Medical Imaging
- Kidney Stones and Urolithiasis Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
University of Pittsburgh Medical Center
2004-2025
University of Pittsburgh
2017-2024
UPMC Hillman Cancer Center
2023-2024
UPMC Presbyterian
2023
Pittsburg State University
2023
UPMC Health System
2020-2022
Merck Serono (Italy)
2019
University of Michigan
2010-2017
Michigan Medicine
2014-2016
Society of Interventional Radiology
2015
In an attempt to more completely define the histopathologic features of portal vein hyperperfusion or small-for-size syndrome (PHP/SFSS), we strictly identified 5 PHP/SFSS cases among 39 (5/39; 13%) adult living donor liver transplants (ALDLT) completed between 11/01 and 09/03. Living segments consisting 3 right lobes, 1 left lobe, lateral segment, with a mean allograft-to-recipient weight ratio (GRWR) 1.0±0.3 (range 0.6 1.4), were transplanted without complications, initially, into 6...
Purpose In 90 Y microsphere radioembolization ( RE ), accurate post‐therapy imaging‐based dosimetry is important for establishing absorbed dose versus outcome relationships developing future treatment planning strategies. Additionally, accurately assessing distributions because of concerns unexpected activity deposition outside the liver. Quantitative imaging by either SPECT or PET challenging. model based methods are necessary scatter correction energy window‐based not feasible with...
719 Background: Localized, dual balloon catheter-mediated, intra-arterial delivery of gemcitabine (IAG) targeted to tumors/tissue can provide higher local drug potency (1). Furthermore, IAG may result in a decreased systemic concentration and associated side effects. In patients with locally advanced pancreatic cancer (LAPC), this approach is currently being tested the TIGeR-PaC Phase 3 clinical trial. Herein we report results 19-patient pharmacokinetics (PK) sub-study analysis within...
To determine the feasibility of spleen stiffness measurement in evaluation portal hemodynamics patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) placement.We prospectively correlated as measured by shear wave velocity with pressure and gradient TIPS procedures. Twenty-three consecutive referred for placement a were enrolled. Included our study 19 whom was obtained before, immediately after, 1 to 3 days after placement. Spleen calculating Young modulus estimated from...
Modern neuroimaging techniques have led to increased identification of angiographically occult cerebral angiomatous malformations. Cavernous angiomas or cavernomas account for approximately 16% all cerebrovascular Little is reported about the etiology risk acquiring these lesions. This report suggests a possible association between acquired intracranial vascular malformations and long-term survivors after craniospinal external beam radiation therapy indicating that greater understanding...
Three-dimensional (3D)/4-dimensional (4D) sonographic measurement of blood volume flow in transjugular intrahepatic porto systemic shunt revision with the intention objective assessment patency.A total 17 patients were recruited (12 male and 5 female; mean age, 55 years; range, 30-69 years). An ultrasound system equipped a 2.0-5.0-MHz probe was used to acquire multivolume 3D/4D color Doppler data sets assess prerevision postrevision flow. Volume computed offline based on principle surface...
Coronary artery disease is a leading cause of mortality in the U.S. and percutaneous coronary intervention with stent placement common treatment. Stents often fail through in-stent restenosis. Periodically monitoring restenosis could help alert physician any problems earlier, reduce myocardial reinfarctions, improve outcomes. Currently, there are no inexpensive noninvasive techniques to monitor patency. We describe an X-ray-addressable blood pressure (X-BP) microsensor. The X-BP has column...
Six patients with hydrocephalus who were treated cerebrospinal fluid (CSF) shunts became refractory to serosal absorption of CSF. All subsequently ventriculo-gallbladder shunts. The surgical technique and long-term results evaluated by retrospective review the hospital records. Detailed evaluation 1 6 has suggested a dynamic role for gallbladder in function
Treatment of hypovascular tumors, such as pancreatic adenocarcinoma, is challenging owing to inefficient drug delivery. This report examines the potential mechanism localized delivery via transarterial microperfusion (TAMP) using a proprietary adjustable double-balloon occlusion catheter in porcine model.
We present a novel implantable X-ray-addressable MEMS Blood Pressure sensor, the X-BP, for noninvasive and cost-effective surveillance of coronary in-stent restenosis. successfully fabricated tested X-BP sensor its pressure response curve. placed in stent prove adequate visibility clinically realistic scenario.
Venous thromboembolism (VTE), particularly thrombi in the inferior vena cava (IVC) and pulmonary embolism, can occur after successful extracorporeal membrane oxygenation (ECMO) be associated with adverse outcomes including death. VTE is related to presence of a venous cannula some cases inadequate anticoagulation caused by clinical bleeding. We have developed simple method for guidewire exchange femoral ECMO working catheter intravascular ultrasound (IVUS) IVC filter placement, describe...
Transarterial radioembolization (TARE) with (90)Y microspheres delivers low dose rate radiation (LDR) to intrahepatic tumors. In the current study, we examined clonogenic survival, DNA damage, and cell cycle distribution in hepatocellular carcinoma (HCC) lines treated LDR combination varying doses schedules of 5-fluorouracil (5-FU), gemcitabine, sorafenib. Radiosensitization was seen 1 3 μM 5-FU (enhancement ratio 2.2-13.9) 30 100 nM gemcitabine 1.9-2.9) administered 24 hours before (0.26...
TPS773 Background: Prognosis for locally advanced pancreatic cancer (LAPC) remains dismal even with advances in therapy. Beyond systemic therapies, local disease control is important these patients. Local double balloon mediated delivery of intra-arterial gemcitabine (IAG) was demonstrated to be safe this patient population a prior study 1 . TIGeR-PaC an ongoing Phase-3 clinical trial comparing the efficacy approach compared standard care IV gemcitabine/nab-paclitaxel (GN) patients LAPC....
2521 Background: Delivery barriers due to intratumoral pressure and immunosuppression related myeloid-derived suppressor cells (MDSC) in liver tumors have created challenges for immunotherapy. TLR9 agonists seem improve response ICI. PERIO-01 is a first-in-man trial of PEDD SD-101 using hepatic arterial infusion (HAI) with ICI MUM. Methods: an open-label phase 1 given by HAI MUM (NCT04935229). The study consists dose-escalation cohorts alone (Cohort A), nivolumab B), or + ipilimumab C)....
<h3>Background</h3> MUM-LM are resistant to ICIs for several reasons including the prevalence of myeloid-derived suppressor cells (MDSCs). PFS has been limited, even with approved therapies such as tebentafusp (median 3.3 months) grade 3/4 AE rates typically >30%. TLR9 agonists capable MDSC polarization but drug delivery historically limited using an intra-tumoral approach. Pressure-enabled (PEDD<sup>TM</sup>) SD-101, a agonist, potential overcome these barriers improve outcomes....