A5007117355- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Clinical Nutrition and Gastroenterology
- Xenotransplantation and immune response
- Immune Cell Function and Interaction
- Organ Donation and Transplantation
- Pancreatic function and diabetes
- Hepatitis C virus research
- Liver physiology and pathology
- Cytomegalovirus and herpesvirus research
- Hepatitis B Virus Studies
- Signaling Pathways in Disease
- Hematopoietic Stem Cell Transplantation
- Organ and Tissue Transplantation Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Diabetes and associated disorders
- Viral-associated cancers and disorders
- Liver Diseases and Immunity
- RNA Interference and Gene Delivery
- Neurological Complications and Syndromes
University of Chicago
2015-2025
BC Centre for Disease Control
2025
Chinese University of Hong Kong
2003-2024
Reproductive Science Center
2024
University of Hong Kong
2012-2024
Stanford University
2010-2023
Hospital of the University of Pennsylvania
2023
University of California, San Francisco
1998-2022
University of Chicago Medical Center
2017-2022
James Cook University
2022
Improvements in the prevention or control of rejection kidney and liver have been largely interchangeable (1, 2) then applicable, with very little modification, to thoracic other organs.However, mechanism by which anti treatment permits any these grafts be "accepted" has an immunological enigma (3, 4).We proposed recently that exchange migratory leukocytes between transplant recipient consequent long-term cellular chimerism both is basis for acceptance all whole-organ allografts xenografts...
Changes in organ allocation policy 2002 reduced the number of adult patients on liver transplant waiting list, changed characteristics recipients and increased receiving simultaneous liver-kidney transplantation (SLK). The transplants peaked 2006 declined marginally 2007 2008. During this period, there was an increase donor age, Donor Risk Index, candidates MELD exception scores with hepatocellular carcinoma. In contrast, a decrease retransplantation rates, grafts from either living or...
To evaluate the long-term survival outcomes of a large cohort liver transplant recipients and to identify static changing factors that influenced these over time.Liver transplantation has been accepted as therapeutic option for patients with end-stage disease since 1983, continual improvements in patient result advances immunosuppression medical management, technical achievements, procurement preservation. Although many reports, including registry data, have delineated short-term influence...
The Banff Working Group on Liver Allograft Pathology reviewed and discussed literature evidence regarding antibody-mediated liver allograft rejection at the 11th (Paris, France, June 5-10, 2011), 12th (Comandatuba, Brazil, August 19-23, 2013), 13th (Vancouver, British Columbia, Canada, October 2015) meetings of Conference Pathology. Discussion continued online. primary goal was to introduce guidelines consensus criteria for diagnosis provide a comprehensive update all Schema recommendations....
Fifty-nine patients with prior hepatitis B virus infection underwent orthotopic liver transplantation. During the first 2 mo, mortality was not significantly different in virus-infected group (25.5%) vs. a virus-immune control (21%). Beyond mortality, rate of graft loss, need for retransplantation and incidence abnormal function were higher group. Treatment attempted passive immunization, combined active alpha-interferon or nothing. The clinical outcome influenced by any these therapies....
This study analyzed the incidence and timing of biliary tract complications after orthotopic liver transplantation (OLTx) in 1792 consecutive patients. These results were then compared with those previously reported series. Finally, recommendations made on appropriate management strategies.Technical OLTx have a significant impact patient graft survival. One principal technical advances has been standardization techniques for reconstruction. Nonetheless, still occur. A 1983 report from...
Nonarterialized orthotopic liver transplantation with no immunosuppression was performed in 13 mouse-strain combinations. Two strain combinations major histocompatibility complex class I and II minor disparity had 20% 33% survival of more than 100 days, but the other 11 combinations, including four that were fully allogeneic all only I, or disparities, yielded 45% to 100% days. Long-living recipients permanently accepted donor-strain heterotopic hearts transplanted on same day skin 3 mo...
Immunosuppression has been sporadically discontinued by noncompliant liver allograft recipients for whom an additional 4 1/2 years of follow-up is provided. These anecdotal observations prompted a previously reported prospective drug withdrawal program in 59 recipients. This series increased to 95 patients whose weaning was begun between June 1992 and March 1996, 8.4±4.4 (SD) after replacement. A further obtained the 5 self-weaned patients. The prospectively weaned (93 livers; 2...
This report summarizes a recent meeting cosponsored by the American Society of Transplant Physicians and Association for Study Liver Diseases to formulate minimal criteria which patients with severe liver disease will be placed on waiting list transplantation. The participants agreed that only in immediate need transplantation should list. Patients not anticipation some future such therapy. It was could assist but replace clinical judgment transplant professionals at individual centers....
Given the shortage of cadaveric organs, we began a study utilizing NHBD for OLTx and KTx. There were 24 between January 1989 September 1993. These donors divided into 2 groups: uncontrolled (G1) (n = 14) patients whose organs recovered following period CPR; controlled (G2) 10) procured after sustaining cardiopulmonary arrest (CA) extubation in an operating room setting. Eight kidneys 5 livers discarded because macroscopic or biopsy findings. In G1, 22/27 (81.5%) transplanted; 14/22 (64%)...
We have shown previously that granulocyte-macrophage colony-stimulating factor-stimulated mouse bone marrow-derived MHC class II+dendritic cell (DC) progenitors are deficient in surface expression of the costimulatory molecules B7-1(CD80) and B7-2 (CD86) can induce alloantigen-specific T-cell anergy vitro. To test vivo relevance these findings, 2×106B10 (H2b) DC (NLDC 145+, II+, B7-1dim, B7-2-/dim) induced hyporesponsiveness vitro were injected systemically into normal C3H (H2k) recipients....
In a prospective, multicenter, open-label study, de novo liver transplant patients were randomized at day 30±5 to (i) everolimus initiation with tacrolimus elimination (TAC Elimination) (ii) reduced-exposure (EVR+Reduced TAC) or (iii) standard-exposure Control). Randomization TAC Elimination was terminated prematurely due higher rate of treated biopsy-proven acute rejection (tBPAR). EVR+Reduced noninferior Control for the primary efficacy endpoint (tBPAR, graft loss death 12 months...
Objective To assess the long-term efficacy of intestinal transplantation under tacrolimus-based immunosuppression and therapeutic benefit newly developed adjunct immunosuppressants management strategies. Summary Background Data With advent tacrolimus in 1990, intestine began to emerge as therapy for failure. However, a high risk rejection, with consequent need acute chronic high-dose immunosuppression, has inhibited its widespread application. Methods During an 11-year period, divided into...