A5004027880- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Diseases and Glomerulopathies
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Merger and Competition Analysis
- European and Russian Geopolitical Military Strategies
- Viral-associated cancers and disorders
- Military History and Strategy
- Vasculitis and related conditions
- Cancer Diagnosis and Treatment
- European and International Contract Law
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Systemic Lupus Erythematosus Research
- EU Law and Policy Analysis
- Cytomegalovirus and herpesvirus research
- Military and Defense Studies
- Chronic Kidney Disease and Diabetes
- Renin-Angiotensin System Studies
- Drug-Induced Hepatotoxicity and Protection
- Hormonal Regulation and Hypertension
- Complement system in diseases
Edinburgh Royal Infirmary
2013-2025
University of Edinburgh
2009-2024
Allen Institute for Brain Science
2024
Institut du Cerveau
2024
Centre for Inflammation Research
2004-2024
Queen's Medical Centre
2020
Edinburgh Cancer Research
2019
Association for Research and Industrial Development of Natural Resources
2015
Western General Hospital
1993-2013
British Heart Foundation
2011
The Banff Working Group on Liver Allograft Pathology reviewed and discussed literature evidence regarding antibody-mediated liver allograft rejection at the 11th (Paris, France, June 5-10, 2011), 12th (Comandatuba, Brazil, August 19-23, 2013), 13th (Vancouver, British Columbia, Canada, October 2015) meetings of Conference Pathology. Discussion continued online. primary goal was to introduce guidelines consensus criteria for diagnosis provide a comprehensive update all Schema recommendations....
In life-threatening coronavirus disease (COVID-19), corticosteroids reduce mortality, suggesting that immune responses have a causal role in death. Whether this deleterious inflammation is primarily direct reaction to the presence of severe acute respiratory syndrome 2 (SARS-CoV-2) or an independent immunopathologic process unknown.
Abstract Purpose: Patients with metastatic adenocarcinoma of unknown origin are a common clinical problem. Knowledge the primary site is important for their management, but histologically, such tumors appear similar. Better diagnostic markers needed to enable assignment metastases likely sites on pathologic samples. Experimental Design: Expression profiling 27 candidate was done using tissue microarrays and immunohistochemistry. In first (training) round, we studied 352 adenocarcinomas, from...
<h3>Background</h3> Stem/progenitor cell niches in tissues regulate stem/progenitor differentiation and proliferation through local signalling. <h3>Objective</h3> To examine the composition formation of stem progenitor niches. <h3>Methods</h3> The hepatic niche independent models liver injury activation rodents humans was studied. identify origin cells, sex-mismatched bone marrow transplants mice, who had received choline–ethionine-deficient-diet to induce activation, were used. matrix...
The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to key focus on impact microvascular inflammation and biopsy-based transcript analysis Classification, further sessions were devoted other aspects kidney transplant pathology, particular T cell-mediated rejection, activity chronicity indices, digital xenotransplantation, clinical trials, surrogate...
Alcoholic liver disease has emerged as a leading indication for hepatic transplantation, although it is controversial use of resources. We aimed to examine all aspects transplantation associated with alcohol abuse.Retrospective cohort analysis 123 alcoholic patients median 7 years follow-up at one center.In addition alcohol, 43 (35%) had another possible factor contributing cirrhosis. Actuarial patient and graft survival rates were, respectively, 84% 81% (1 year); 72% 66% (5 years); 63% 59%...
Interaction of macrophages with apoptotic cells involves multiple steps including recognition, tethering, phagocytosis, and anti-inflammatory macrophage responses. Defective cell clearance is associated pathogenesis autoimmune disease. CD14 a surface receptor that functions in vitro the removal by human murine macrophages, but its mechanism action has not been defined. Here, we demonstrate as tethering for cells. Significantly, CD14−/− vivo are defective clearing tissues, suggesting broad...
Kupffer cells are the resident macrophage population of liver and have previously been implicated in pathogenesis hepatic ischemia-reperfusion injury (IRI). major site expression heme oxygenase-1 (HO-1), which has shown to anti-inflammatory actions protect animals from oxidative injury. circulating monocytes were selectively ablated using liposomal clodronate (LC) CD11b DTR mouse before induction ischemia. cell depletion resulted loss HO-1 increased susceptibility IRI, whereas ablation did...
Acute antibody-mediated rejection (AMR) occurs in a small minority of sensitized liver transplant recipients. Although histopathological characteristics have been described, specific features that could be used (1) to make generalizable scoring system and (2) trigger more in-depth analysis are needed screen for this rare but important finding. Toward goal, we created training validation cohorts putative acute AMR control cases from 3 high-volume programs; these were evaluated blindly by 4...
To determine the spectrum and outcome of colorectal diseases occurring in adult liver allograft recipients.A retrospective cohort analysis clinical, microbiological histopathological data regarding disease.Forty three out 302 primary recipients were transplanted followed up (at median 42 months) at a tertiary referral centre/teaching hospital.Out patients, 43 (14%) investigated (by endoscopy and/or laparotomy) for symptoms disease after orthotopic transplantation. The were: diarrhoea (n =...
Despite good evidence for p53 dysfunction in human hepatocellular carcinomas, little is known of the significance to normal hepatocytes and whether relevant early hepatocarcinogenesis. We have therefore examined consequences targeted deficiency regulation apoptosis, proliferation, ploidy. was silent liver did not affect progression from diploidy polyploidy aging liver. However, primary culture absence resulted increased hepatocyte proliferation indices decreased sensitivity inhibition by...
The syndrome of apparent mineralocorticoid excess arises from nonfunctional mutations in 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2), an enzyme that inactivates cortisol and confers aldosterone specificity on the receptor. Loss 11betaHSD2 permits glucocorticoids to activate receptor, hypertension is presumed arise volume expansion secondary renal sodium retention. An null mouse was generated inbred C57BL/6J genetic background, allowing survival adulthood. 11betaHSD2(-/-) mice had...
Heat shock proteins (Hsps) are protective in models of transplantation, yet practical strategies to upregulate them remain elusive. The heat protein 90-binding agent (HBA) geldanamycin and its analogs (17-AAG 17-DMAG) known Hsps confer cellular protection but have not been investigated a model relevant transplantation. We examined the ability HBAs Hsp expression renal adenocarcinoma (ACHN) cells vitro mouse kidney ischemia-reperfusion (I/R) injury. Hsp70 gene was increased 30-40 times ACHN...