A5044372150- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- HER2/EGFR in Cancer Research
- Cancer and Skin Lesions
- Colorectal Cancer Screening and Detection
- Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Neurological diseases and metabolism
- Orthopedic Surgery and Rehabilitation
- Gene expression and cancer classification
- Neurogenesis and neuroplasticity mechanisms
- Various Chemistry Research Topics
- AI in cancer detection
- Genetic Neurodegenerative Diseases
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Foot and Ankle Surgery
- Veterinary Orthopedics and Neurology
- Cardiovascular Health and Disease Prevention
- Hereditary Neurological Disorders
- History and advancements in chemistry
- RNA and protein synthesis mechanisms
University of Chicago
2024-2025
Nova Southeastern University
2024
Pacific Centre for Reproductive Medicine
2021-2024
University of Utah
2015-2024
University of Edinburgh
2001-2023
McGill University
2015-2023
University of California, Santa Barbara
2015-2023
Ashoka University
2018-2023
Royal Shakespeare Company (United Kingdom)
2018-2023
University of Oxford
1980-2023
Glial cells produce myelin and contribute to axonal morphology in the nervous system. Two membrane proteolipids, PLP DM20, were shown be essential for integrity of myelinated axons. In absence PLP-DM20, mice assembled compact sheaths but subsequently developed widespread swellings degeneration, associated predominantly with small-caliber nerve fibers. Similar absent dysmyelinated shiverer mice, which lack basic protein (MBP), recurred MBP*PLP double mutants. Thus, fiber was probably...
PURPOSE: The morphologic and molecular phenotype of breast cancers may help identify patients who are likely to carry germline mutations in BRCA1 BRCA2. This study evaluates the immunohistochemical profiles tumors arising with these genes. MATERIALS AND METHODS: Samples obtained from International Breast Cancer Linkage Consortium were characterized morphologically immunohistochemically using antibodies estrogen receptor, progesterone HER-2 (c-erbB-2 oncogene), p53 protein. RESULTS: more...
Background : We have previously demonstrated that breast cancers associated with inherited BRCA1 and BRCA2 gene mutations differ from each other in their histopathologic appearances of these types differs patients unselected for family history (i.e., sporadic cancers). now conducted a more detailed examination cytologic architectural features tumors. Methods Specimens tumor tissue (5-µm-thick sections) were examined independently by two pathologists, who unaware the case or control subject...
Increasing UVB radiation at the earth's surface might have adverse effects on in vivo immunologic responses humans. We prospectively randomized subjects to test whether epicutaneous immunization is altered by prior administration of biologically equalized doses UV radiation. Multiple antigens upper inner arm skin (UV protected) were used elicit contact sensitivity responses, which quantitated measuring increases thickness. If a dose sufficient induce redness (erythemagenic) was administered...
<h3>Objective:</h3> Age at onset of diagnostic motor manifestations in Huntington disease (HD) is strongly correlated with an expanded CAG trinucleotide repeat. The length the normal repeat allele has been reported also to influence age onset, interaction allele. Due profound implications for mechanism and modification, we tested whether allele, between alleles, or presence a second affects HD signs. <h3>Methods:</h3> We modeled natural log-transformed as function lengths alleles their by...
Post-concussion syndrome (PCS) can affect up to 20%–30% of patients with mild closed head injury (mCHI), comprising incomplete recovery and debilitating persistence post-concussional symptoms. Eye movements relate closely the functional integrity injured brain eye movement function is impaired post-acutely in mCHI. Here, we examined whether PCS continue show disparities at 3–5 months following mCHI compared good recovery. We hypothesized that might provide sensitive objective markers ongoing...
An Enumeration of the Indian Species Acanthaceæ Get access Thomas Anderson, M.D., F.L.S. Superintendent 1Royal Botanical Gardens, Calcutta. Search for other works by this author on: Oxford Academic Google Scholar Journal Linnean Society, Volume 9, Issue 39, April 1867, Pages 425–454, https://doi.org/10.1111/j.1095-8339.1867.tb01308.x Published: 05 January 2009 Article history Received: 01 November 1866
The bryostatins are protein kinase C modulators with unique structural features and potential anticancer neurological activities. These complex polyketides were isolated from the marine bryozoan Bugula neritina, but recent studies indicate that they produced by uncultured symbiotic bacterium "Candidatus Endobugula sertula" ("E. sertula"). Here we present putative biosynthetic genes: five modular polyketide synthase (PKS) genes, a discrete acyltransferase, β-ketosynthase,...
Background: The feasibility of replacing the ankle joint has been a matter speculation for long time. In recent years, designs prostheses have improved, and three designs, all used without bone cement, currently dominate market. However, documentation clinical results use these is sparse. We reviewed intermediate-term fifty-one consecutive Scandinavian Total Ankle Replacements (STAR). Methods: Between 1993 1999, ankles were replaced with an uncemented, hydroxyapatite-coated STAR total...
ABSTRACT The marine bryozoan, Bugula neritina , is the source of bryostatins, a family macrocyclic lactones with anticancer activity. Bryostatins have long been suspected to be bacterial products. B. harbors uncultivated gamma proteobacterial symbiont “ Candidatus Endobugula sertula.” In this work several lines evidence are presented that show most likely bryostatins. complex polyketides similar secondary metabolites synthesized by modular type I polyketide synthases (PKS-I). PKS-I gene...
On review of the histology 1050 primary breast carcinomas, 103 cases infiltrating lobular carcinoma were identified and clinical survival data collected in each case. The tumours then separated into four groups on basis histological pattern these shown to have significantly different times. Assessment presence situ carcinoma, elastosis intracytoplasmic lumina was performed case effect features investigated. In addition stage disease at presentation, major significant factor predicting...
The clinical and pathological features of nine cases granulomatous mastitis were compared with those 10 duct ectasia/periductal (DE/PM), all which associated active inflammation. Granulomatous affects a younger age group, although there is some overlap DE/PM, it has distinctive features, particularly lobule centred distribution, for the term "granulomatous lobular mastitis" recommended. There strong tendency persistence or recurrence. Our occurred in parous women, five them within three...
There is a need for objective imaging markers of Parkinson's disease status and progression. Positron emission tomography single photon computed studies have suggested patterns abnormal cerebral perfusion in as potential functional biomarkers. This study aimed to identify an arterial spin labelling magnetic resonance-derived network accessible, non-invasive alternative. We used pseudo-continuous measure grey matter 61 subjects with range motor cognitive impairment, including patients...
The accuracy of clinical examination, mammography and fine needle aspiration cytology in identifying malignancy has been assessed 1655 breast masses from two time periods. Clinical examination remained consistent at but 9 per cent all carcinomas were considered benign by both techniques (sensitivity 91 cent). Fine cytology, when performed multiple aspirators the first study period, had a sensitivity only 66 for malignancy. During second period study, aspirates single aspirator, rose to 99...
Abstract The p53 locus on the short arm of chromosome 17 at 17p 13.1 was examined for loss heterozygosity, mutation, mRNA and protein expression in 60 primary breast cancers. Allele around detected 19/45 informative tumours (42%). mutations evolutionarily conserved exons 5 to 9 were 17/60 (28%) by amplification mismatch confirmed direct DNA sequencing. Northern blot 36/59 (61%) tumours, using antibody 1801 frozen‐tissue sections 13/44 examined. mutation significantly associated with...
A histological review of 1003 invasive breast carcinomas identified 51 tumours in which the component showed a predominantly cribriform pattern. These separated into two groups; 35 exclusively or with limited extent tubular elements only, designated 'classical' carcinoma and 16 also contained areas less well differentiated carcinoma, 'mixed' carcinoma. At follow-up, 10 to 21 years after diagnosis, none patients classical had died as result this initial 30 remained alive. Of remaining...