Julian Peto
A5016473306- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Cervical Cancer and HPV Research
- Genetic factors in colorectal cancer
- Cancer Risks and Factors
- Nutrition, Genetics, and Disease
- Occupational and environmental lung diseases
- Estrogen and related hormone effects
- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Bioinformatics and Genomic Networks
- Genital Health and Disease
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Gene expression and cancer classification
- DNA Repair Mechanisms
- Air Quality and Health Impacts
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Acute Lymphoblastic Leukemia research
London School of Hygiene & Tropical Medicine
2016-2025
University of London
2013-2024
University Hospital Southampton NHS Foundation Trust
2020
University of Cambridge
2019
Institute of Cancer Research
2004-2016
British Heart Foundation
2015
Cancer Council Victoria
2015
Medical Research Council
2015
University of Glasgow
2015
Karolinska Institutet
2012-2014
A recent report that 93 per cent of invasive cervical cancers worldwide contain human papillomavirus (HPV) may be an underestimate, due to sample inadequacy or integration events affecting the HPV L1 gene, which is target polymerase chain reaction (PCR)-based test was used. The formerly HPV-negative cases from this study have therefore been reanalysed for serum antibodies and DNA. Serology 16 VLPs, E6, E7 performed on 49 66 were a 48 866 HPV-positive in original study. Moreover, 55 biopsies...
SummaryThe contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage mutation analysis in 237 families, each with at least four cases cancer, collected the Breast Cancer Linkage Consortium. Families were included without regard occurrence ovarian or other cancers. Overall, disease linked an estimated 52% 32% neither gene 16% (95% confidence interval [CI] 6%–28%), suggesting predisposition genes. The majority (81%) breast-ovarian families due BRCA1, most others (14%)...
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance dominant susceptibility genes conferring high risk disease. genomic linkage search was performed with 15 high-risk cancer families that were unlinked BRCA1 locus on chromosome 17q21. This analysis localized second locus, BRCA2 , 6-centimorgan interval 13q12-13. Preliminary evidence suggests confers but, unlike does not confer substantially elevated ovarian cancer.
Projections for the period 1995–2029 suggest that number of men dying from mesothelioma in Western Europe each year will almost double over next 20 years, 5000 1998 to about 9000 around 2018, and then decline, with a total quarter million deaths 35 years. The highest risk be suffered by born 1945–50, whom 1 150 die mesothelioma. Asbestos use remained high until 1980, substantial quantities are still used several European countries. These projections based on fit simple age birth cohort model...
BACKGROUND: Mutations in the BRCA1 and BRCA2 genes are found most families with cases of both breast ovarian cancer or many early-onset cancer. However, an outbred population, prevalence mutations patients who were unselected for a family history this disease has not been determined. METHODS: detected blood samples from two population-based series young Britain. RESULTS: 15 (5.9%) 254 women diagnosed before age 36 years (nine [3.5%] six [ 2.4%] BRCA2) (4.1%) 363 ages through 45 (seven [1.9%]...
Background : We have previously demonstrated that breast cancers associated with inherited BRCA1 and BRCA2 gene mutations differ from each other in their histopathologic appearances of these types differs patients unselected for family history (i.e., sporadic cancers). now conducted a more detailed examination cytologic architectural features tumors. Methods Specimens tumor tissue (5-µm-thick sections) were examined independently by two pathologists, who unaware the case or control subject...
The effects of extra-pleural pneumonectomy (EPP) on survival and quality life in patients with malignant pleural mesothelioma have, to our knowledge, not been assessed a randomised trial. We aimed assess the clinical outcomes who were randomly assigned EPP or no context trimodal therapy Mesothelioma Radical Surgery (MARS) feasibility study.MARS was multicentre controlled trial 12 UK hospitals. Patients aged 18 years older had pathologically confirmed deemed fit enough undergo included. In...
To investigate the proportion of breast cancers arising in patients with germ line BRCA1 and BRCA2 mutations expressing basal markers developing predictive tests for identification high-risk patients.Histopathologic material from 182 tumors mutation carriers, 63 109 controls, collected as part international Breast Cancer Linkage Consortium were immunohistochemically stained CK14, CK5/6, CK17, epidermal growth factor receptor (EGFR), osteonectin.All five commoner than control (CK14: 61%...
A collaborative study including centres in the United Kingdom, Australia, and New Zealand was instituted 1970 to determine incidence of cancer patients treated for at least three months with azathioprine, cyclophosphamide, or chlorambucil. Follow-up 3823 renal transplant recipients showed an almost 60-fold increase non-Hodgkin's lymphoma together excess squamous-cell skin mesenchymal tumours. series 1349 without transplants same tumours, though a less extent. These preliminary findings...