Pavel Vodiĉka
A5004651940- Genetic factors in colorectal cancer
- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Colorectal Cancer Screening and Detection
- Telomeres, Telomerase, and Senescence
- Effects and risks of endocrine disrupting chemicals
- Cancer-related Molecular Pathways
- Digestive system and related health
- BRCA gene mutations in cancer
- DNA and Nucleic Acid Chemistry
- RNA Research and Splicing
- Circular RNAs in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug Transport and Resistance Mechanisms
- Nutrition, Genetics, and Disease
- Glycosylation and Glycoproteins Research
- Restless Legs Syndrome Research
Charles University
2016-2025
Czech Academy of Sciences, Institute of Experimental Medicine
2016-2025
Czech Academy of Sciences
2015-2024
General University Hospital in Prague
2012-2024
Cancer Institute (WIA)
2013-2024
Institute of Medical Biology
2013-2023
Thomayer University Hospital
2013-2022
German Cancer Research Center
2012-2022
Heidelberg University
2012-2022
Vita-Salute San Raffaele University
2020-2022
Abstract Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank GWA consortia, we found that a one standard deviation increment average acceleration was (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) (OR: 0.66, CI: 0.48 0.90, 0.01)....
Colorectal cancer (CRC) is one of the main causes death neoplasia. Demand for predictive and prognostic markers to reverse this trend increasing. Long non-coding RNA HOTAIR (Homeobox Transcript Antisense Intergenic RNA) overexpression in tumors was previously associated with poor prognosis higher mortality different carcinomas. We analyzed expression levels tumor blood incident sporadic CRC patients relation their overall survival aim evaluate surrogate marker CRC. Tissue donor group...
Worldwide, colorectal cancer (CRC) is the third most common cancer, with highest mortality rates occurring in Central Europe. The use of chemotherapy to treat CRC limited by inter-individual variability drug response and development cell resistance. ATP-binding cassette (ABC) transporters play a crucial role resistance efflux anticancer agents outside cells. aim this study was explore transcript levels all human ABCs tumours non-neoplastic control tissues from patients collected before first...
Glycemic traits-such as hyperinsulinemia, hyperglycemia, and type 2 diabetes-have been associated with higher colorectal cancer risk in observational studies; however, causality of these associations is uncertain. We used Mendelian randomization (MR) to estimate the causal effects fasting insulin, 2-hour glucose, glycated hemoglobin (HbA1c), diabetes cancer.
Recent evidence indicate that small non-coding RNA molecules, called micro-RNAs (miRNAs), can bind to the 3′ untranslated regions (UTRs) of messenger RNAs and interfere with their translation, thereby regulating cell growth, differentiation, apoptosis tumorigenesis. Genetic polymorphisms reside on miRNA-binding sites. Thus, it is conceivable miRNA regulation may be affected by UTRs. Since gene deregulation one key mechanisms which cells progress cancer, we hypothesize common within...
We analysed the associations between genetic polymorphisms in genes coding for DNA repair enzymes XPD (exon 23 A → C, K751Q), XPG 15 G D1104H), XPC K939Q), XRCC1 10 A, R399Q) and XRCC3 7 C T, T241 M) levels of chromosomal aberrations (CAs) single-strand breaks (SSBs) peripheral lymphocytes a central European population. also measured irradiation-specific rates 8-oxoguanines these individuals. An elevated frequency CAs was observed individuals with exon allele ( AA AC ) genotypes F = 3.6, P...
We investigated association between polymorphisms in DNA repair genes and the capacity to damage induced by γ-irradiation base oxidation a healthy population. Irradiation-specific rates were significantly decreased individuals with XRCC1 Arg399Gln homozygous variant genotype (0.45 ± 0.47 SSB/10 9 Da) than those wild-type (1.10 0.70 Da, P = 0.0006, Mann–Witney U -test). The oxidative was among hOGG1 Ser326Cys (0.37 0.28 compared (0.83 0.79 0.008, Investigation of combinations showed that...
Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years age. Affected individuals suffer from uncomfortable sensations and urge move lower limbs that occurs mainly resting situations during evening or at night. Moving walking leads improvement symptoms. Concomitantly, patients report sleep disturbances consequences such as reduced daytime functioning. We conducted genome-wide association study (GWA) for...
Low selenium (Se) status correlates with increased risk of colorectal cancer (CRC). Since Se exerts its biological roles through the selenoproteins, genetic variations in selenoprotein genes may influence susceptibility to CRC. This study analysed 12 single-nucleotide polymorphisms (SNPs) [glutathione peroxidase 1 ( GPX1 ), GPX4 , 15 kDa SEP15 S SELS P (SEPP1) and thioredoxin reductase 2 TXNRD2 )] that code for a key protein incorporation [SECIS-binding SBP2 antioxidant defence [superoxide...
Molecular sensing in the lingual mucosa and gastro-intestinal tract play a role detection of ingested harmful drugs toxins. Therefore, genetic polymorphisms affecting capability initiating these responses may be critical for subsequent efficiency avoiding and/or eliminating possible threats to organism. By using tagging approach region Taste Receptor 2R38 (TAS2R38) gene, we investigated all common variation this gene relation colorectal cancer risk with case-control study German population...
Abstract Background Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or sex is unclear. Further, metabolic alterations mediating effects on CRC are not fully understood. Methods We examined sex- and site-specific associations with adiposity-associated metabolites explain CRC. Genetic variants from genome-wide association studies body mass index (BMI) waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), 123...
Background & AimsHuman studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and binding protein 3 (IGFBP3) colorectal cancer risk have reported inconsistent results. We conducted complementary serologic Mendelian randomization (MR) analyses to determine whether alterations in IGF1 or IGFBP3 are associated with development.MethodsSerum were measured blood samples collected from 397,380 participants the UK Biobank, 2006 through 2010. Incident cases...