A5058538154- Carcinogens and Genotoxicity Assessment
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Migration, Health and Trauma
- Energy and Environment Impacts
- Air Quality and Health Impacts
- Colorectal Cancer Screening and Detection
- Health and Conflict Studies
- Innovations in Medical Education
- Health, Environment, Cognitive Aging
- Food Security and Health in Diverse Populations
- Problem and Project Based Learning
- Alcohol Consumption and Health Effects
- Substance Abuse Treatment and Outcomes
- Acute Lymphoblastic Leukemia research
- Natural product bioactivities and synthesis
- BRCA gene mutations in cancer
- Global Health Workforce Issues
- Clinical Reasoning and Diagnostic Skills
- Effects and risks of endocrine disrupting chemicals
- Genomics, phytochemicals, and oxidative stress
- Cultural Competency in Health Care
- Interpreting and Communication in Healthcare
- Genomics and Chromatin Dynamics
- Acute Myeloid Leukemia Research
Charles University
2008-2024
Czech Academy of Sciences, Institute of Experimental Medicine
2006-2019
Czech Academy of Sciences
2007-2019
University of Leicester
2007
We investigated association between polymorphisms in DNA repair genes and the capacity to damage induced by γ-irradiation base oxidation a healthy population. Irradiation-specific rates were significantly decreased individuals with XRCC1 Arg399Gln homozygous variant genotype (0.45 ± 0.47 SSB/10 9 Da) than those wild-type (1.10 0.70 Da, P = 0.0006, Mann–Witney U -test). The oxidative was among hOGG1 Ser326Cys (0.37 0.28 compared (0.83 0.79 0.008, Investigation of combinations showed that...
The Czech Republic has one of the highest incidences colorectal cancer (CRC) in world. To assess role genetic variants on disease, we genotyped polymorphisms TP53 (rs17878362:A(1)>A(2), rs1042522:G>C, rs12947788:C>T, and rs17884306:G>A), CDKN1A (rs1801270:C>A rs1059234:C>T), CDKN2A (rs3731249:G>A, rs11515:C>G, rs3088440:C>T) genes 614 hospital-based CRC cases matched controls from country. Despite tendency toward differential distribution variant allele frequencies for some polymorphisms,...
ABSTRACT Introduction A growing body of research is examining how healthcare systems are responding to the increasing numbers migrants and resulting superdiversity patients. The aim this article identify explain communication barriers in provision Ukrainian war refugees Czech Republic from perspectives professionals intercultural mediators. Methods exploratory case study based on a qualitative analysis semi‐structured interviews with frontline health professionals: 20 doctors 10 nurses....
Anti-tumor and antiviral activities of various aroma samples, including cinnamic acid, β-caryophyllene, caryophyllene oxide, nerolidol (synthetic natural samples), trans, trans-farnesol, farnesol (isomeric mixture), longifolene, geranic acid a farnesol-rich ylang-fraction were investigated using HeLa Jurkat cell lines. Using CytoTox-96®-Assay we observed strong anti-tumor effects natural- synthetic nerolidol-samples at concentrations less than 5 μM. Furthermore, reduced the number cells to...
Objective: The Czech Republic is characterized by high alcohol consumption and well known as the world's biggest consumer of beer. In contrast, in Norway relatively low. this article, we describe discuss policy development since mid-1980s to present its impact on compare our findings, including dynamics total drinking patterns among young people, with situation Norway. Methods: study uses methodology "process tracing". Selected national statistics, research outcomes related documents were...
Abstract The sesquiterpene alcohols cis-nerolidol, α-bisabolol, cedrol, patchoulol, and santalol were screened for cytotoxicity cytoproliferative activity on HeLa cell using Cytotoxicity Detection Kit (LDH) the Cell Proliferation Reagent WST-1, respectively. Actinomycin D curcumin as well plant acids geranic salicylic acid used reference samples, all known their cytotoxic properties. Among studied, cis-nerolidol possessed strongest properties (16.5 μM ± 6.7). Low influence viability was...
The arrival of war refugees from Ukraine has tested the functionality a number Czech public and social policy systems.In this article, we focus on healthcare system its response to new situation.We use concept health resilience, which is ability maintain or improve access services while ensuring long-term sustainability.We specifically absorptive capacity dimension.This refers continue function well provide same level basic (i.e.quantity, quality, equity access) population protection even in...
Abstract Background The Czech Republic is one of the countries with low rate digitization health care processes, and current legislation provides only isolated elements electronic care. Due to COVID-19 pandemic, general practitioners (GPs) in Republic, as other countries, had rapidly switch telemedicine visits. Information on patient perspectives about these visits lacking. Our study aims understand patients' perceptions at GPs during COVID-19, identify barriers benefits primary Methods A...
Abilitator questionnaire, a self-assessment tool for measuring work ability and functioning.The project translated the questionnaire into Arabic, Somali Kurdish.The appropriateness of was tested through cognitive interviews (n = 60).Later mobile version with versions in target languageswas produced tested. Key findings:The preliminary findings from suggest that there are cultural differences how concepts functioning understood.Both were described primarily as work-related capacities.Learning...