Jenny Chang‐Claude
- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Genetic factors in colorectal cancer
- Nutrition, Genetics, and Disease
- Cancer Risks and Factors
- Colorectal Cancer Screening and Detection
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Cancer survivorship and care
- Nutritional Studies and Diet
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Breast Cancer Treatment Studies
- Bioinformatics and Genomic Networks
- Cancer, Lipids, and Metabolism
- Effects of Radiation Exposure
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Global Cancer Incidence and Screening
- Gene expression and cancer classification
- Nutrition and Health in Aging
- Colorectal Cancer Treatments and Studies
- DNA Repair Mechanisms
- Genomic variations and chromosomal abnormalities
Heidelberg University
2016-2025
German Cancer Research Center
2016-2025
University Hospital Heidelberg
2015-2025
University Medical Center Hamburg-Eppendorf
2016-2025
Universität Hamburg
2016-2025
University Cancer Center Hamburg
2016-2025
DKFZ-ZMBH Alliance
2010-2024
Eppendorf (Germany)
2024
John Wiley & Sons (United States)
2024
Liechtenstein Institute
2024
SummaryThe contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage mutation analysis in 237 families, each with at least four cases cancer, collected the Breast Cancer Linkage Consortium. Families were included without regard occurrence ovarian or other cancers. Overall, disease linked an estimated 52% 32% neither gene 16% (95% confidence interval [CI] 6%–28%), suggesting predisposition genes. The majority (81%) breast-ovarian families due BRCA1, most others (14%)...
Background For virtually every patient with colorectal cancer (CRC), hematoxylin–eosin (HE)–stained tissue slides are available. These images contain quantitative information, which is not routinely used to objectively extract prognostic biomarkers. In the present study, we investigated whether deep convolutional neural networks (CNNs) can prognosticators directly from these widely available images. Methods and findings We hand-delineated single-tissue regions in 86 CRC slides, yielding more...
Background: Colonoscopy with detection and removal of adenomas is considered a powerful tool to reduce colorectal cancer (CRC) incidence. However, the degree protection achievable in population setting high-quality colonoscopy resources remains be quantified. Objective: To assess association between previous risk for CRC. Design: Population-based case–control study. Setting: Rhine-Neckar region Germany. Patients: A total 1688 case patients 1932 control participants aged 50 years or older....
Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone (PR) expression status of the tumors.
Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...
To investigate the proportion of breast cancers arising in patients with germ line BRCA1 and BRCA2 mutations expressing basal markers developing predictive tests for identification high-risk patients.Histopathologic material from 182 tumors mutation carriers, 63 109 controls, collected as part international Breast Cancer Linkage Consortium were immunohistochemically stained CK14, CK5/6, CK17, epidermal growth factor receptor (EGFR), osteonectin.All five commoner than control (CK14: 61%...
Data for multiple common susceptibility alleles breast cancer may be combined to identify women at different levels of risk. Such stratification could guide preventive and screening strategies. However, empirical evidence genetic risk is lacking. We investigated the value using 77 cancer-associated single nucleotide polymorphisms (SNPs) stratification, in a study 33 673 cases 381 control European origin. tested all possible pair-wise multiplicative interactions constructed 77-SNP polygenic...
Considerable experimental and epidemiological evidence suggests that elevated endogenous sex steroids — notably androgens oestrogens promote breast tumour development. In spite of this evidence, postmenopausal androgen replacement therapy with dehydroepiandrosterone (DHEA) or testosterone has been advocated for the prevention osteoporosis improved sexual well-being. We have conducted a case–control study nested within European Prospective Investigation into Cancer Nutrition. Levels DHEA...
Abstract Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank GWA consortia, we found that a one standard deviation increment average acceleration was (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) (OR: 0.66, CI: 0.48 0.90, 0.01)....
Background: Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone deficiency, estrogen excess, both an or lack adrenal androgens (dehydroepiandrosterone [DHEA] its sulfate [DHEAS]) as risk factors. We conducted a case–control study nested within European Prospective Investigation into Cancer Nutrition cohort to examine associations serum concentrations subsequent...