A5057853566- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- COVID-19 and healthcare impacts
- Liver Disease Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- S100 Proteins and Annexins
- Neuroendocrine Tumor Research Advances
- Bone and Dental Protein Studies
- Circular RNAs in diseases
- Lung Cancer Research Studies
- Sepsis Diagnosis and Treatment
- Infection Control and Ventilation
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Gastric Cancer Management and Outcomes
- Testicular diseases and treatments
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Oral and Maxillofacial Pathology
Düsseldorf University Hospital
2020-2025
Heinrich Heine University Düsseldorf
2020-2025
RWTH Aachen University
2013-2023
FOM University of Applied Sciences for Economics and Management
2023
Universitätsklinikum Aachen
2012-2022
University of Thessaly
2020-2022
University General Hospital Attikon
2020-2022
University of Michigan
2020-2022
Hvidovre Hospital
2022
Copenhagen University Hospital
2022
The aim of this retrospective study was to investigate the impact coronavirus disease 2019 (COVID-19) pandemic on cancer diagnosis in general and specialized practices Germany. This included a total 102,009 patients aged ≥18 years newly diagnosed with 1660 Germany from January May 2020. Practices general, gynecology, ear, nose, throat (ENT), dermatology, urology practices. New diagnoses all types corresponded cancers not previously documented database for given patient. number new per...
Summary Background and Aims Phase III trials have established atezolizumab plus bevacizumab as the novel standard of care for patients with unresectable hepatocellular carcinoma (HCC). However, these raised concerns regarding treatment efficacy in non‐viral HCC, it remains unclear whether combination immunotherapy is safe effective advanced cirrhosis. Methods One hundred HCC initiated therapy at our centre between January 2020 March 2022. The control cohort consisted 80 who received either...
Significance Statement Nearly half of hospitalized patients with coronavirus disease 2019 (COVID-19) develop AKI, 20% requiring dialysis. High levels soluble urokinase plasminogen activator receptor (suPAR)—an immune mediator kidney injury—predispose to AKI in various clinical scenarios, including critical illness. suPAR modulate mitochondrial respiration and induce the generation reactive oxygen species proximal tubular cells, sensitizing them additional insults. In a multicenter...
In an effort to contain the effects of coronavirus disease (COVID-19) pandemic, health care systems worldwide implemented telemedical solutions overcome staffing, technical, and infrastructural limitations. Germany, a multitude are already being used, while new approaches rapidly developed in response crisis. However, extent current implementation within different settings, user's acceptance perception, as well hindering technical regulatory obstacles remain unclear.The aim this paper is...
OBJECTIVE Diabetes mellitus (DM) is a major risk factor for severe coronavirus disease 2019 (COVID-19) reasons that are unclear. RESEARCH DESIGN AND METHODS We leveraged the International Study of Inflammation in COVID-19 (ISIC), multicenter observational study 2,044 patients hospitalized with COVID-19, to characterize impact DM on in-hospital outcomes and assess contribution inflammation hyperglycemia attributed DM. measured biomarkers collected at hospital admission glucose levels insulin...
Nucleotide-binding oligomerization domain-like receptor-family pyrin domain-containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis. Mechanisms and downstream signaling remain incompletely understood. Here, we studied the role of IL-18 hepatic stellate cells (HSCs), its impact on
Abstract Background The search for biomarkers to identify suitable candidates immune checkpoint inhibitor (ICI) therapy remains ongoing. We evaluate how soluble levels of the next generation Lymphocyte Activation Gene-3 (sLAG-3) and its association with circulating T lymphocyte subsets could pose as a novel biomarker predict outcome ICI therapy. Methods Circulating sLAG3 were analyzed using multiplex immunoassay in n = 84 patients undergoing advanced solid cancer, accompanied by flow...
Abstract Severe coronavirus disease 2019 (COVID‐19) is a hyperinflammatory syndrome. The biomarkers of inflammation best suited to triage patients with COVID‐19 are unknown. We conducted prospective multicenter observational study adult hospitalized specifically for from February 1, 2020 October 19, 2022. Biomarkers measured included soluble urokinase plasminogen activator receptor (suPAR), C‐reactive protein, interleukin‐6, procalcitonin, ferritin, and D‐dimer. In‐hospital outcomes examined...
Abstract Background Hepatocellular Carcinoma (HCC) and cholangiocellular adenocarcinoma (CCA) are the most common primary liver tumors representing a major global health burden. In early disease stages, tumor resection may provide long-term survival in selected patients. However, morbidity mortality rates still relatively high after extended surgery with perioperative bacterial infections complications. this study, we evaluate impact of infection on postoperative overall (OS) patients...
Abstract Cholangiocarcinoma (CCA) represents a rare form of primary liver cancer with increasing incidence but dismal prognosis. Surgical treatment has remained the only potentially curative option, it remains unclear which patients benefit most from surgery, highlighting need for new preoperative stratification strategies. In clinical routine, CA19-9 widely used tumor marker in CCA patients. However, data on prognostic value are limited and often inconclusive, mostly due to small cohort...
miR-192-5p has gained increasing relevance in various diseases, however, its function acute liver injury is currently unknown. We analysed serum levels and hepatic expression mice after ischaemia reperfusion (I/R) as well toxic injury. On a functional level, miRNA were the different cell-compartments context of tumour necrosis factor (TNF)-dependent cell death. detected increased I/R- carbon tetrachloride (CCl4)-induced correlated with degree damage presence death by TUNEL stainings...
Background: The COVID-19 pandemic represents an unprecedented global challenge and implicates a wide range of burden on medical professionals. Here, we evaluated the perception among professionals in Germany.Methods: A total n = 2827 participated online survey between 27 March 11 April.Results: While most participants stated that Germany was well prepared rated measures taken by their employer as positive, subgroup analyses revealed decisive differences. preventive were significantly worse...
The prognosis and quality of life heart failure patients is determined to a significant extent by co-morbidities. New data suggest that may be associated with an increased incidence cancer. present retrospective study investigates this association in large collective outpatients failure.This cohort assessed the cancer initial diagnosis matched non-heart 1274 general practices Germany between January 2000 December 2018. based on Disease Analyser database (IQVIA), which contains drug...
The objective of this study was to assess the trend from open modern minimally invasive (laparoscopic and robot-assisted) surgical techniques for colorectal cancer (CRC) in Germany, with a particular focus on hospital mortality, postoperative complications, length stay.
Abstract Purpose Iron deficiency anemia (IDA) is the most common form of worldwide, resulting in a high burden disease. Accumulating evidence suggests that IDA associated with development gastrointestinal (GI) cancers. Methods Data from database (IQVIA) primary care practices Germany adult patients first diagnosed between January 2005 and December 2021 were retrospectively analyzed compared 1:1 propensity score-adjusted cohort without IDA. Study outcomes stomach cancer or colorectal (CRC)...
Small benign testicular masses are often misinterpreted as germ cell tumors and immediate inguinal orchiectomy is performed. We analyzed the diagnostic therapeutic workup of to improve preoperative stratification algorithms.We performed a retrospective, single center analysis records 522 patients diagnosed with primary unknown malignant potential.A total 28 (5%) showed tumor after resection, including Leydig in 9 (32%), epidermoid cysts adenomatoid 8 (29%) Sertoli 2 (7%). The median volume...