A5012107602- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Tryptophan and brain disorders
- Pharmacological Receptor Mechanisms and Effects
- Venous Thromboembolism Diagnosis and Management
- Surgical site infection prevention
- Long-Term Effects of COVID-19
- Infection Control in Healthcare
- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Photoreceptor and optogenetics research
- Infection Control and Ventilation
- Stress Responses and Cortisol
- COVID-19 and Mental Health
- Bacterial Identification and Susceptibility Testing
- Malaria Research and Control
- Muscle and Compartmental Disorders
- Thermal Regulation in Medicine
- Lipid Membrane Structure and Behavior
- Adipokines, Inflammation, and Metabolic Diseases
- Vector-borne infectious diseases
- Neurobiology and Insect Physiology Research
- Neural dynamics and brain function
- Mosquito-borne diseases and control
Rigshospitalet
2017-2024
University of Copenhagen
2017-2024
Copenhagen University Hospital
2017-2024
Hvidovre Hospital
2020-2021
Heinrich Heine University Düsseldorf
2020
University of Thessaly
2020
Düsseldorf University Hospital
2020
University General Hospital Attikon
2020
University of Michigan
2020
Significance Statement Nearly half of hospitalized patients with coronavirus disease 2019 (COVID-19) develop AKI, 20% requiring dialysis. High levels soluble urokinase plasminogen activator receptor (suPAR)—an immune mediator kidney injury—predispose to AKI in various clinical scenarios, including critical illness. suPAR modulate mitochondrial respiration and induce the generation reactive oxygen species proximal tubular cells, sensitizing them additional insults. In a multicenter...
To examine differences in mortality and/or severe acute respiratory syndrome between selective serotonin reuptake inhibitor- (SSRI) users and non-SSRI up to 60 days after a positive SARS-CoV-2 real-time reverse transcription PCR test.Retrospective cohort study including all Danish residents above the age of eighteen with test from 26 February, 2020 5 October, 2021. The follow-up period was days. primary outcome all-cause mortality, secondary syndrome. Exposure interest SSRI use. Differences...
Elevated soluble urokinase Plasminogen Activator Receptor (suPAR) is a biomarker associated with adverse outcomes. We aimed to investigate the associations between plasma suPAR levels (testing cut-offs ⩽4, 4-6, and ⩾6 ng/mL) risk of 14-day mortality, mechanical ventilation in patients that tested positive for SARS-CoV-2.Observational cohort study presenting symptoms COVID-19 at Department Emergency Medicine, Amager Hvidovre Hospital, Denmark from March 19th, 2020 April 3rd, 2020. Plasma was...
BackgroundSevere acute respiratory syndrome coronavirus 2 (The Covid-19 pandemic) strains health care capacity. Better risk stratification, with discharge of patients a predicted mild disease trajectory, can ease this burden. Elevated blood-soluble urokinase plasminogen activator receptor (suPAR) has previously been shown to be associated intubation in confirmed COVID-19 patients.ObjectiveTo evaluate whether point-of-care measures suPAR presenting the emergency department (ED) symptoms...
Background Venous thromboembolism (VTE) contributes significantly to COVID-19 morbidity and mortality. The urokinase receptor system is involved in the regulation of coagulation. Levels soluble plasminogen activator (suPAR) reflect hyperinflammation are strongly predictive outcomes COVID-19. Whether suPAR levels identify patients with at risk for VTE unclear. Methods Results We leveraged a multinational observational study hospitalized D-dimer measured on admission. In 1960 (mean age, 58...
ABSTRACT OBJECTIVE To examine if baseline soluble urokinase plasminogen activator receptor (suPAR) can predict whether patients with COVID-19 symptoms will need mechanical ventilation during a 14-day follow-up. Furthermore, to differences in demographics, clinical signs, and biomarkers tested either positive or negative for SARS-CoV-2. DESIGN Prospective cohort study including presenting of COVID-19. SETTING Copenhagen University Hospital Amager Hvidovre, Denmark. PARTICIPANTS 407 were...
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) has revolutionized identification of bacteria and is becoming available in an increasing number laboratories malaria-endemic countries. The purpose this proof-of-concept study was to explore the potential MALDI-TOF as a diagnostic tool for direct detection quantification Plasmodium falciparum human blood.Three different P. strains (3D7, HB3 IT4) were cultured synchronized following standard protocols....
The action potential (AP) is an electrical impulse elicited by depolarization of the neuronal membrane from resting (around $\ensuremath{-}70\text{ }\text{ }\mathrm{mV}$). It propagates along axon, allowing for rapid and distant communication. Recently, it was claimed that two APs traveling in opposite direction will pass unhindered through each other (penetrate) upon collision [Gonzalez-Perez et al.Phys. Rev. X 4, 031047 (2014)]. We tested this claim under carefully controlled conditions...