A5056697512- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Cancer Cells and Metastasis
- Neonatal Respiratory Health Research
- Estrogen and related hormone effects
- Long-Term Effects of COVID-19
- HER2/EGFR in Cancer Research
- Interprofessional Education and Collaboration
- Nursing Roles and Practices
- Palliative Care and End-of-Life Issues
- Schizophrenia research and treatment
- Primary Care and Health Outcomes
- Allergic Rhinitis and Sensitization
- Respiratory Support and Mechanisms
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Mental Health and Psychiatry
- Cancer Risks and Factors
- COVID-19 and healthcare impacts
- Dialysis and Renal Disease Management
- Air Quality and Health Impacts
- Chemotherapy-induced cardiotoxicity and mitigation
Michigan Medicine
2020-2025
Université Laval
2023-2025
Concello de Cervo
2023-2024
Columbia University
2024
University of Leicester
2024
University of Michigan–Ann Arbor
2005-2024
University of Calgary
2021-2024
Advocate Health Care
2024
Atrium Medical Cente
2024
Sisters of Mercy Health System
2024
Virus-induced wheezing episodes in infancy often precede the development of asthma. Whether infections with specific viral pathogens confer differential future asthma risk is incompletely understood.To define relationship between illnesses and early childhood development.A total 259 children were followed prospectively from birth to 6 years age. The etiology timing respiratory during assessed using nasal lavage, culture, multiplex reverse transcriptase-polymerase chain reaction....
Multiple myeloma is an incurable plasma cell malignancy with a complex and incompletely understood molecular pathogenesis. Here we use whole-exome sequencing, copy-number profiling cytogenetics to analyse 84 samples. Most cases have subclonal structure show clusters of variants, including driver mutations. Serial sampling reveals diverse patterns clonal evolution, linear differential response branching evolution. Diverse processes contribute the mutational repertoire, kataegis somatic...
Abstract This article analyzes the available evidence to address airborne, aerosol transmission of SARS‐CoV‐2. We review and present three lines evidence: case reports for asymptomatic individuals in association with studies that show normal breathing talking produce predominantly small droplets size are subject transport; limited empirical data have recorded aerosolized SARS‐CoV‐2 particles remain suspended air hours transport over distances including outside rooms intrabuilding, broader...
Abstract Objectives To estimate the incidence, risk factors, and outcomes associated with in-hospital cardiac arrest cardiopulmonary resuscitation in critically ill adults coronavirus disease 2019 (covid-19). Design Multicenter cohort study. Setting Intensive care units at 68 geographically diverse hospitals across United States. Participants Critically (age ≥18 years) laboratory confirmed covid-19. Main outcome measures In-hospital within 14 days of admission to an intensive unit mortality....
Immunohistochemistry of primary breast cancer is routinely used to guide changes in therapy at the time relapse. Retrospective reviews suggest that estrogen receptor (ER), progesterone (PR) and human epidermal growth factor type 2 (HER2) may differ between loco-regional recurrence or distant metastases. The Breast Recurrence In Tissues Study (BRITS) was a large, multicentre, prospective study examine ER, PR HER2.Matched recurrent tissue samples were prospectively collected from 205 women...
Daycare attendance and siblings are associated with viral-induced wheezing in children. Preexisting immunologic factors may influence the expression of viral infections infancy, turn, recurrent development immune responses. A total 285 children were enrolled Childhood Origins Asthma Project at birth followed for least 1 year. Cord blood 1-year mononuclear cells stimulated phytohemagglutinin, cytokine-response profiles measured by enzyme-linked immunosorbent assay. Nasal lavage was performed...
STAT3 is the key mediator of apoptosis in mammary gland. We demonstrate here that LIF physiological activator STAT3, because involuting glands Lif-;/-; mice, pSTAT3 absent and target, C/EBPδ, not upregulated. Similar to Stat3knockouts, exhibit delayed involution, reduced elevated levels p53. Significantly, display precocious development during pregnancy, when normally detected. show pERK1/2 significantly at this time,suggesting stage mediates its effects through pERK1/2. Inhibition...
OBJECTIVE Diabetes mellitus (DM) is a major risk factor for severe coronavirus disease 2019 (COVID-19) reasons that are unclear. RESEARCH DESIGN AND METHODS We leveraged the International Study of Inflammation in COVID-19 (ISIC), multicenter observational study 2,044 patients hospitalized with COVID-19, to characterize impact DM on in-hospital outcomes and assess contribution inflammation hyperglycemia attributed DM. measured biomarkers collected at hospital admission glucose levels insulin...
Abstract Severe coronavirus disease 2019 (COVID‐19) is a hyperinflammatory syndrome. The biomarkers of inflammation best suited to triage patients with COVID‐19 are unknown. We conducted prospective multicenter observational study adult hospitalized specifically for from February 1, 2020 October 19, 2022. Biomarkers measured included soluble urokinase plasminogen activator receptor (suPAR), C‐reactive protein, interleukin‐6, procalcitonin, ferritin, and D‐dimer. In‐hospital outcomes examined...
Variation in assay sensitivity was studied more than 90 laboratories that assayed 4 formalin-fixed, paraffin-processed breast and ovarian carcinoma cell lines with graded levels of HER-2/neu protein overexpression known gene amplification, addition to carcinomas fixed processed the laboratories. Main methods were HercepTest (DAKO, Ely, England) individualized protocols using a polyclonal antibody CB11 clone. While proportion achieving appropriate results significantly higher for participants...
In order to resolve the question of which ovarian steroid stimulates normal human mammary epithelial cell proliferation, we have implanted pieces breast tissue subcutaneously into athymic nude mice. These mice were then treated with slow-release pellets containing estradiol (E2) or progesterone (P) such that serum levels E2 and P increased those seen in women. The proliferative activity implants was assessed by uptake tritiated thymidine receptor expression measured immunocytochemically....
Abstract The effect of ingestion oral contraceptives (OCP) on cell proliferation and oestrogen (ER) progesterone receptor (PR) expression the epithelial cells normal human breast was compared with findings in controls not taking OCPs. Histologically tissue removed during operation for fibroadenoma or reduction mammoplasty 216 women whose mean age 28.1 ± 8.5 years (±SD range 14–53 years). During natural cycles proportion expressing ER 3.94 3.71 (% ±SD, 0–20.8, n = 51), while those PR it 12.1...
Delirium is an acute brain dysfunction associated with increased risk of mortality and future dementia. To describe the prevalence clinically documented delirium in United States on World Awareness Day 2023. This a sub-analysis prospective, cross-sectional, online, international survey. All health care settings were eligible, exception operating rooms outpatient clinics. Health clinicians, administrators, researchers completed The primary outcome was at 8:00 a.m. p.m. March 15, Secondary...
Background Health disparities exist in end-of-life (EOL) care. Individuals and communities that are marginalized due to their race, ethnicity, income, geographic location, language, or cultural background experience systemic barriers access receive lower quality EOL Advance care planning (ACP) prepares patients caregivers for decision-making the purpose of promoting high-quality Low engagement ACP among populations is thought have contributed disparity To advance health equity deliver aligns...
Health Effects Institute, 955 Massachusetts Avenue, Cambridge, MA 02139 (address for correspondence) The opinions expressed are those of the author and do not necessarily reflect views Institute or its sponsors.
Objectives. To determine the relative contributions of neuroepilepsy, coping and illness representation variables to psychological adjustment in epilepsy. Design. The study was a cross‐sectional design, contrasting recently diagnosed chronic patients. Neuroepilepsy, representation, were all measured. Method. A total 94 patients studied comprising three groups: patients, cared for hospital clinics, by their GP. measure developed assess each patient's representations Results. Overall, epilepsy...