A5090966146- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Immunodeficiency and Autoimmune Disorders
- Peripheral Neuropathies and Disorders
- Vasculitis and related conditions
- Asthma and respiratory diseases
- Cancer Immunotherapy and Biomarkers
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Adenosine and Purinergic Signaling
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Heparin-Induced Thrombocytopenia and Thrombosis
- Autoimmune Neurological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Sarcoidosis and Beryllium Toxicity Research
- T-cell and B-cell Immunology
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacovigilance and Adverse Drug Reactions
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Mast cells and histamine
Royal North Shore Hospital
2016-2025
The University of Sydney
2016-2025
North Shore Hospital
2009-2024
New South Wales Department of Health
2018-2023
Nationwide Children's Hospital
2023
Northern Sydney Local Health District
2009-2021
University of Mississippi Medical Center
2020-2021
State Street (United States)
2020-2021
American College of Allergy, Asthma and Immunology
2020-2021
Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists
2017-2019
Genetic variation influences susceptibility to clinical tuberculosis (TB). Activation of the P2X(7) receptor on human macrophages induces killing mycobacteria. We have identified polymorphisms in gene that markedly reduce this killing.To determine if P2X7 are associated with increased risk TB, prevalence four was assessed individuals from Southeast Asia, where majority patients TB our study originate. The association these subsequently investigated two separate case-control cohorts and...
The P2X7 receptor is a ligand-gated cation channel that highly expressed on mononuclear leukocytes and mediates ATP-induced apoptosis killing of intracellular pathogens. There wide variation in function between subjects, explained part by four loss-of-function polymorphisms (R307Q, E496A, I568N, 5′-intronic splice site polymorphism), as well rare mutations. In this study, we report the allele frequencies 11 non-synonymous describe fifth polymorphism gene (1096C → G), which changes Thr357 to...
Abstract Protective immunity to mycobacterial infections requires activation of the antibacterial mechanisms infected macrophages. It has previously been reported that ATP treatment mycobacteria-infected macrophages induces apoptosis mediated via P2X7 pathway and this leads death both host cell internalized bacilli. We have recently identified a single nucleotide polymorphism in gene (1513A→C), with 1–2% prevalence homozygous state, which codes for nonfunctional receptor. IFN-γ-primed, from...
Introduction Penicillin allergy labels (PALs) are reported in 1 10 hospitalised patients globally and associated with inferior patient, hospital microbiological outcomes; however, the majority incorrect should be removed. Direct oral penicillin challenge has been demonstrated to a safe effective method for removal of PALs. However, question whether single dose is sufficient ascertain true status remains unanswered, some studies suggesting that extended challenges 3 or more days superior...
Stimulation of the P2X7 purinergic receptor (P2X7) in bacille Calmette-Guerin (BCG)-infected human macrophages with extracellular adenosine triphosphate (ATP) leads to pore formation and killing mycobacteria. We examined effect polymorphisms gene on capacity kill mycobacteria.Polymorphisms mutations were identified by both DNA sequence analysis determination uptake ethidium time-resolved flow cytometry. Macrophages from affected subjects infected Mycobacterium bovis BCG. Apoptosis was...
Increasing implementation of the highly efficacious immune checkpoint inhibitors (ICIs) has raised awareness their various complications in form immune-related adverse events (irAEs). Transverse myelitis following ICIs is thought to be a rare but serious neurologic irAE and knowledge limited about this distinct clinical entity.
A 35-year-old man of Chinese ethnicity presented to the emergency department with fever, rash, mouth pain and visual impairment after two weeks therapy allopurinol. On examination, patient had a generalized maculopapular orolabial ulceration ([Figure 1][1]), keratoconjunctivitis
Abstract Background Immune checkpoint inhibitors (ICI) have become the standard of care in many oncological conditions but are associated with a spectrum renal immune-related adverse events (IrAEs). We aimed to describe spectrum, histology, management and outcomes IrAE patients metastatic melanoma undergoing ICI therapy. Methods conducted retrospective review 23 diagnosis treated between January 2017 April 2019 who developed IrAE. Baseline demographic data, biochemical histopathological...