A5047201441- Bone health and treatments
- Pancreatic function and diabetes
- Classical Antiquity Studies
- Ancient Mediterranean Archaeology and History
- Parathyroid Disorders and Treatments
- Diabetes and associated disorders
- Fibroblast Growth Factor Research
- Metabolism, Diabetes, and Cancer
- Genetics and Neurodevelopmental Disorders
- Bone health and osteoporosis research
- Diabetes Management and Research
- Historical and Architectural Studies
- Ancient Egypt and Archaeology
- Medical Imaging and Pathology Studies
- Erythrocyte Function and Pathophysiology
- Historical, Religious, and Philosophical Studies
- African history and culture studies
- Archaeology and Historical Studies
- Cannabis and Cannabinoid Research
- Thyroid Disorders and Treatments
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Protein Kinase Regulation and GTPase Signaling
- Byzantine Studies and History
- Pancreatic and Hepatic Oncology Research
Icahn School of Medicine at Mount Sinai
2015-2024
New York Proton Center
2022-2023
University of California, Los Angeles
2023
Institute of Nutrition, Metabolism and Diabetes
2019-2023
Royal Danish Defence College
2023
University of Aberdeen
2022-2023
Iowa State University
2023
Sanofi (France)
2023
Sanofi (United States)
2023
University of California, Berkeley
1985-2022
Thyroid nodules are common in adults, but only a small fraction of them is malignant. Fine-needle aspiration (FNA) cytology provides definitive diagnosis benign or malignant disease many cases, whereas about 25% indeterminate, hindering most appropriate management.The objective the investigation was to study clinical utility molecular testing thyroid FNA samples with indeterminate cytology.Residual material from 1056 consecutive used for prospective analysis that included assessment cell...
In 50 consecutive patients with cancer-associated hypercalcemia, we measured nephrogenous cyclic AMP, tubular phosphorus threshold, fasting calcium excretion, plasma 1,25-dihydroxyvitamin D, and immunoreactive parathyroid hormone as determined by four region-specific anitserums. Nephrogenous AMP excretion was elevated in 41 suppressed nine (means, 5.85 vs. 0.51 nmol per 100 ml of glomerular filtrate). There no overlap between these groups. When compared 15 primary hyperparathyroidism, the...
Tumors from patients with humoral hypercalcemia of cancer produce a parathyroid Hormone-Related protein (PTHRP). We have developed two region-specific immunoassays capable measuring PTHRP in plasma: an immunoradiometric assay directed toward amino acid sequence 1 to 74 and radioimmunoassay 109 138.
Humoral hypercalcemia of malignancy is a common paraneoplastic syndrome that appears to be mediated in many instances by parathyroid hormone-like peptide. Poly(A)+ RNA from human renal carcinoma associated with this was enriched preparative electrophoresis and used construct an cDNA library phage lambda gt10. The screened codon-preference oligonucleotide synthesized on the basis partial N-terminal amino acid sequence tumor-derived peptide, 2.0-kilobase identified. encodes 177 protein...
Prolonged immobilization may result in hypercalcemia, hypercalciuria, and osteoporosis. Although bone resorption is central to this syndrome, the mechanism of uncertain. In particular, role systemic calcium-regulating hormones remains unclear. 14 immobilized subjects we measured fasting calcium excretion, 24-hour urinary excretion during restricted intake, renal phosphorus threshold, plasma 1,25-dihydroxyvitamin D, nephrogenous cyclic AMP, immunoreactive parathyroid hormone. Mean serum...
Humoral hypercalcemia of malignancy is a common paraneoplastic syndrome which characterized by resulting from secretion tumors circulating bone-resorbing factor.Evidence suggests that in many instances this factor an adenylate cyclase-stimulating protein shares features with, but distinct from, parathyroid hormone (PTH).The current report describes the purification to homogeneity humoral malignancyassociated tumor novel, basic, highly potent PTHlike protein.This differs previously described...
A major goal in diabetes research is to find ways enhance the mass and function of insulin secreting β-cells endocrine pancreas prevent and/or delay onset or even reverse overt diabetes. In this Perspectives Diabetes article, we highlight contrast between relatively large body information that available regard signaling pathways, proteins, mechanisms together provide a road map for efforts regenerate rodents versus scant human β-cells. To state ignorance regarding β-cell signaling, suggest...
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. cell lncRNAs are often type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role gene diabetes, the function remains largely unknown. In this study, we investigated cell-specific transcription factors using transcript knockdowns co-expression network analysis. This revealed that concert with to...
Humoral hypercalcemia of malignancy (HHM) results from elaboration by tumors a circulating bone-resorbing factor (s). The specific mechanism responsible for this bone resorption is poorly understood, and no comprehensive study employing quantitative histomorphometric analyses biopsies obtained living patients with HHM has been reported. We describe histology histomorphometry in seven defined biochemically (elevated nephrogenous cAMP excretion) histologically (no tumor biopsy sample) as...
Hepatocyte growth factor (HGF) is produced in pancreatic mesenchyme-derived cells and islet cells. <i>In vitro</i>, HGF increases the insulin content proliferation of islets. To study role <i>in vivo</i>, we have developed three lines transgenic mice overexpressing mHGF using rat II promoter (RIP). Each RIP-HGF line displays clear expression mRNA protein islet. RIP-mHGF are relatively hypoglycemic post-prandial fasting states compared with their normal littermates. They display inappropriate...
Parathyroid hormone-related protein (PTHrP) is a prohormone that posttranslationally processed to family of mature secretory forms, each which has its own cognate receptor(s) on the cell surface mediate actions PTHrP. In addition being secreted via classical pathway and interacting with receptors in paracrine/autocrine fashion, PTHrP appears be able enter nucleus directly following translation influence cellular events an "intracrine" fashion. this report, we demonstrate can targeted...
This volume captures the individuality, national and personal identity, cultural exchange, self-consciousness that have long been sensed as peculiarly potent in Hellenistic world. The fields of history, literature, art, philosophy, religion are each presented using format two essays followed by a response. Conveying direction focus learning, eighteen leading scholars discuss issues liberty versus domination, appropriation accommodation, increasing diversity citizen roles dress gesture...
The culture media of three cell lines, a human prostate carcinoma (PC3), rat Leydig tumor (Rice-500), and carcinosarcoma (WRC-256), that were derived from tumors associated with humoral hypercalcemia malignancy (HHM), examined for stimulation adenylate cyclase in ROS 17/2.8 osteoblastic cells bone resorptive activity culture. Cells nonhypercalcemic variant the WRC256 served as control. Extracts solid tumors, lung adenocarcinoma patient HHM two normocalcemic patients (lung colon), also...
The factors that regulate pancreatic beta cell proliferation are not well defined. In order to explore the role of murine placental lactogen (PL)-I (mPL-I) in islet mass regulation<i>in vivo</i>, we developed transgenic mice which mPL-I is targeted using rat insulin II promoter. Rat II-mPL-I displayed both fasting and postprandial hypoglycemia (71 105 mg/dl, respectively) as compared with normal (92 129 mg/dl; <i>p</i> < 0.00005 for both). Plasma concentrations were inappropriately elevated,...