A5100444844- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Image Processing Techniques and Applications
- Pancreatic function and diabetes
- Force Microscopy Techniques and Applications
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Pregnancy and preeclampsia studies
- S100 Proteins and Annexins
- Diabetes Management and Research
- Human-Automation Interaction and Safety
- Esophageal Cancer Research and Treatment
- Influenza Virus Research Studies
- Spaceflight effects on biology
- Cancer, Lipids, and Metabolism
- Bacterial Infections and Vaccines
- Cardiovascular and Diving-Related Complications
- Peptidase Inhibition and Analysis
- Clusterin in disease pathology
- Extracellular vesicles in disease
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Pneumonia and Respiratory Infections
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
Icahn School of Medicine at Mount Sinai
2015-2024
XinHua Hospital
2021-2024
Shanghai Jiao Tong University
2012-2024
Commercial Aircraft Corporation of China (China)
2021
Jilin University
2021
Zhengzhou University
2019-2020
Chinese Center For Disease Control and Prevention
2013
Academy of Military Medical Sciences
2011
Abstract Ferroptosis is a novel form of programmed cell death triggered by iron‐dependent lipid peroxidation and has been associated with various diseases, including cancer. Erastin, an inhibitor system Xc‐, which plays critical role in regulating ferroptosis, identified as inducer ferroptosis cancer cells. In this study, we investigated the impact butyrate, short‐chain fatty acid produced gut microbiota, on erastin‐induced lung Our results demonstrated that butyrate significantly enhanced...
The previous study has shown that transcriptional factor MEOX1 could promote proliferation and sphere formation ability of non-small cell lung cancer (NSCLC) cells, however, we found mRNA was lowly expressed in tissues compared to normal adjacent tissues, expression positively correlated with the survival patients, especially adenocarcinoma patients. Functional experiments using vitro vivo revealed stable overexpression significantly suppressed ability, promoted cycle arrest G2 phase,...
Cancer stem cells (CSCs) are considered key contributors to tumor progression, and ferroptosis has been identified as a potential target for CSCs. We have previously shown that butyrate enhances the induced by erastin in lung cancer cell, this study aimed investigate impact of on progression To these effects, we constructed series vitro experiments, including 3D non-adherent sphere-formation, cytometry analysis, assessment CSC marker expression, cell migration assay, vivo tumorigenesis...
Abstract The small molecule DYRK1A inhibitor, harmine, induces human beta cell proliferation, expands mass, enhances expression of phenotypic genes, and improves function i n vitro in vivo . It is unknown whether the “pro-differentiation effect” a inhibitor class-wide effect. Here we compare multiple commonly studied inhibitors. Harmine, 2-2c 5-IT increase PDX1, MAFA, NKX6.1, SLC2A2, PCSK1, MAFB, SIX2, SLC30A8, ENTPD3 normal T2D islets. Unexpectedly, GNF4877, CC-401, INDY, CC-401 Leucettine...
Background Invasive meningitis and pneumonia caused by Haemophilus influenzae type b (Hib) is an important cause of childhood mortality in countries where Hib vaccination not routine. We evaluated the non-inferiority a licensed vaccine, PRP-CRM197 compared with second PRP-T, following recommended Chinese immunisation schedule for infants between 6 months 1 year age. Methods In first study phase, 6–12 month-old received two primary doses either (n = 335) or PRP-T vaccine administered month...
Abstract Relevant studies have indicated the association of HCG18 with tumour occurrence and progression. In this study, we observed that PM 2.5 can enhance growth lung adenocarcinoma cells by modulating expression . Further investigations, including overexpression knockout experiments, elucidated suppresses miR‐195, which in turn upregulates ATG14 , resulting upregulation autophagy. Consequently, exposure to leads elevated tissues, increases Atg14 activates autophagy pathways through...
This article presents a new vision-based force measurement method to measure microassembly forces without directly computing the deformation. The shape descriptor of geometric moment invariants is used as feature vector describe implicit relationship between an applied and Then, standard library established map corresponding deformed cantilever under known set vectors. Finally, support machine compares unknown with those in library, implements multi-class classification predicts force....
The measurement of deformation and force for microcantilevers is an important issue in microassembly.An optical method based on local feature point matching the digital image correlation (DIC) proposed.Images a microcantilever before after are obtained by microscope.Using Laplace-of-Gaussian (LOG) operator, points with extreme response values detected scale space images deformation.For each LOG point, affine-invariant closed region extracted which sub-pixel position relocated as center...
To investigate the effects of simulated 100 m Trimix conventional diving on tissue inflammatory cytokines in rabbits.Eight New Zealand rabbits were performed a program which was established according to Haldane theory. The expression levels interferon-gamma(IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), myeloperoxidase(MPO) and matrix metallo proteinase-9 (MMP-9) lung brain tissues detected by Elisa after decompression. wet/dry ratio calculated. serum...