Abstract The function of the hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and expression brain-derived neurotrophic factor (BDNF) may be involved in pathogenesis post-traumatic stress disorder (PTSD). This study aims to explore role HCN1 channel, BDNF, mTOR actions PTSD examine whether synaptic transmission or plasticity is regulation this disease. In present study, rats were exposed single prolonged electric foot shock (SPS&S) procedure, which can induce...

Abstract Immune checkpoint inhibitors (ICIs) are most commonly used for melanoma and non-small cell lung cancer (NSCLC) patients. FAT atypical cadherin 1 (FAT1), which frequently mutates in NSCLC. In this study, we aim to investigate the association of FAT1 mutations with ICI response outcome. We collected somatic mutation profiles clinical information from ICI-treated 631 109 NSCLC samples, respectively. For validation, a pan-cancer cohort 1661 patients an immunotherapy setting was also...

Abstract Purpose Protein tyrosine phosphatase receptor type T (PTPRT), which is a well‐known and mutates frequently in melanoma non‐small cell lung cancer (NSCLC). Our research aims to elucidate its mutation association with immune checkpoint inhibitors (ICI) efficacy. Methods We integrated whole‐exome sequencing (WES) ‐ based somatic profiles clinical characteristics of 631 samples received ICI agents from eight studies 109 NSCLC two studies. For validation, 321 350 immunotherapy targeted...

Background Immune checkpoint inhibitor (ICI) therapy dramatically prolongs melanoma survival. Currently, the identified ICI markers are sometimes ineffective. The objective of this study was to identify novel determinants efficacy. Methods We comprehensively curated pretreatment somatic mutational profiles and clinical information from 631 patients who received blockade immune checkpoints (i.e., CTLA-4, PD-1/PD-L1, or a combination). Significantly mutated genes (SMGs), signatures, potential...

Post-traumatic stress disorder (PTSD) is a debilitating mental with high morbidity and great social economic relevance. However, extant pharmacotherapies of PTSD require long-term use to maintain effectiveness have enormous side effects. The glutamatergic system, especially the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), an important target current research on mechanism PTSD. Postsynaptic AMPAR function expression are known be increased by (2R, 6R)-hydronorketamine...

As an adverse form of early-life stress (ELS), maternal separation (MS) can interfere with the development cognition and behaviors adolescent rodents. Brain-derived neurotrophic factor (BDNF) is involved in regulation brain function, but molecular mechanisms by which BDNF regulates function behavior MS different stressor strengths remain unclear. This descriptive study characterized levels prefrontal cortex (PFC) plasma corticosterone (CORT) from offspring rats exposed to early handling (EH,...

Aging has been demonstrated to play vital roles in the prognosis and treatment efficacy of cancers, including lung adenocarcinoma (LUAD). This novel study aimed construct an aging-related risk signature evaluate immunogenicity LUAD. Transcriptomic profiles clinical information were collected from a total 2518 LUAD patients 12 independent cohorts. The was developed by combining specific gene expression with corresponding regression coefficients. One cohort treated immune checkpoint inhibitor...

Immune checkpoint inhibitors (ICIs) markedly promote the survival outcome of advanced melanoma and non-small cell lung cancer (NSCLC). Clinically, favorable ICI treatment efficacy is noticed only in a smaller proportion patients. Heparan sulfate proteoglycan 2 (HSPG2) frequently mutates both tumors. Herein, we aim to investigate immunotherapeutic immunological roles HSPG2 mutations NSCLC. A total 631 samples 109 NSCLC with somatic mutational profiles clinical immunotherapy data were curated....

Streptococcus pneumoniae is an important pathogen causing invasive diseases such as sepsis, meningitis, and pneumonia. Vaccines have become the most effective way to prevent pneumococcal infections. This phase III trial was designed evaluate immunogenicity safety of a 23-valent polysaccharide vaccine in Chinese healthy population aged >2 years. We conducted randomized, double-blinded, active-controlled, multicenter which 1660 (>2 years age) were randomly assigned 1 : ratio receive 2...

The objective of this study was to assess attitudes towards the use Traditional Chinese Medicine (TCM) for COVID-19 among immigrants in Canada during early stage pandemic.A cross-sectional conducted April 2020 Canada. Individuals aged 16 or older who were origin and living at time survey invited participate an online survey. Descriptive univariate statistics performed describe participant various preventive treatment measures COVID-19. Multiple logistic regression used identify independent...

Introduction Turner syndrome (TS) is a chromosomal disorder that affects phenotypic females who have one intact X chromosome and complete or partial absence of the second sex in association with more clinical manifestations. However, immunological profile TS different origins incompletely understood. Methods In this study, transcriptomic expression profiles 26 (45,X) samples 10 normal karyotype (46,XX) derived from GSE46687 cohort were employed. Differentially expressed immune-related genes...

Fatty acid synthase (FASN) acts as the central member in fatty synthesis and metabolism processes, which regulate oncogenic signals tumor immunogenicity. To date, no studies have reported connection of FASN mutations with ICI efficacy. In this study, from 631 melanoma 109 NSCLC patients who received treatments, we retrospectively curated multiomics profiles treatment data. We also explored potential molecular biological mechanisms behind alterations. patients, were observed to associate a...

Human enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease (HFMD). In previous phase III trial in children, human diploid cell-based inactivated EV71 vaccine elicited specific immune responses protection against associated HFMD. This study aimed to assess the factors influencing severity adverse events observed this trial. was randomized, double-blinded, placebo-controlled, clinical carried out 12,000 children Guangxi Zhuang Autonomous Region, China...

Abstract Background Our objective was to examine cancer risk factor awareness and beliefs about treatment, outcomes, screening, how these are mediated by sociodemographic variables, among Newfoundland Labrador residents. Methods Participants aged 35 74 were recruited through Facebook advertising, a self-administered online questionnaire used collect data. Descriptive statistics, Spearman rank correlations, multivariate logistic regression analyses performed. Results Of the 1048 participants...

Abstract Vitamin D, Ca and dairy products are negatively associated with colorectal cancer (CRC) incidence, but little is known of their influence on CRC survival. To investigate prediagnostic intakes vitamin for relevance to prognosis, we analysed 504 patients enrolled in the Newfoundland Colorectal Cancer Registry Cohort Study who were diagnosed first time between 1999 2003. Follow-up mortality recurrence was through April 2010. Data diet lifestyle factors gathered via a validated,...

SET binding protein 1 (SETBP1) plays crucial roles in various biological processes; however, its involvement cancer immune checkpoint inhibitor (ICI) treatments has never been studied. In this study, we collected a total of 631 melanoma and 109 non-small cell lung (NSCLC) samples treated with ICI agents (i.e., anti-CTLA-4, anti-PD-1/PD-L1, or combination therapy). Additionally, obtained their corresponding somatic mutational profiles. We observed that SETBP1 mutated (SETBP1-MUT) patients...

Objectives: This study investigated the beliefs about cancer treatment, outcomes, and screening among adults aged 50−74 in Newfoundland Labrador whether these or sociodemographic factors were associated with differences colorectal (CRC) behaviours. Methods: analysis uses data collected from an online survey of on awareness prevention NL. Chi-square tests used to assess distributions based CRC behaviour. Logistic regression was identify independently Results: A total 724 participants included...