A5074494657- Retinal Development and Disorders
- PI3K/AKT/mTOR signaling in cancer
- Genomics and Phylogenetic Studies
- Chronic Myeloid Leukemia Treatments
- Ovarian cancer diagnosis and treatment
- Photoreceptor and optogenetics research
- Cancer Mechanisms and Therapy
- Photochromic and Fluorescence Chemistry
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Plant biochemistry and biosynthesis
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Plant Pathogens and Fungal Diseases
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Plant Gene Expression Analysis
- Microtubule and mitosis dynamics
- CAR-T cell therapy research
Beijing Chao-Yang Hospital
2016-2025
Shanghai University
2024-2025
Chengdu Third People's Hospital
2016-2025
Southwest Jiaotong University
2021-2025
Sun Yat-sen University
2004-2025
Capital Medical University
2016-2025
Qingdao University of Technology
2008-2025
The First Affiliated Hospital, Sun Yat-sen University
2019-2025
Zhongshan Hospital
2019-2025
Fudan University
2013-2025
No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2.We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes respiratory Covid-19, and an oxygen saturation (Sao2) 94% or less while they were breathing ambient air ratio partial pressure (Pao2) to fraction inspired (Fio2) than 300 mm Hg. Patients randomly assigned in 1:1 receive either lopinavir-ritonavir...
Abstract Background New therapies are urgently needed for Alzheimer’s disease (AD). Sodium oligomannate (GV-971) is a marine-derived oligosaccharide with novel proposed mechanism of action. The first phase 3 clinical trial GV-971 has been completed in China. Methods We conducted 3, double-blind, placebo-controlled participants mild-to-moderate AD to assess efficacy and safety. Participants were randomized placebo or (900 mg) 36 weeks. primary outcome was the drug-placebo difference change...
Family with sequence similarity 20,-member C (FAM20C) is highly expressed in the mineralized tissues of mammals. Genetic studies showed that loss-of-function mutations FAM20C were associated human lethal osteosclerotic bone dysplasia (Raine Syndrome), implying an inhibitory role this molecule formation. However, vitro gain- and suggested promotes differentiation mineralization mouse mesenchymal cells odontoblasts. Recently, we generated Fam20c conditional knockout (cKO) mice which was...
The aim of this study was to show preclinical efficacy and clinical development potential NVP-BKM120, a selective pan class I phosphatidylinositol-3 kinase (PI3K) inhibitor in human glioblastoma (GBM) cells vitro vivo.The effect NVP-BKM120 on cellular growth assessed by CellTiter-Blue assay. Flow cytometric analyses were carried out measure the cell-cycle, apoptosis, mitotic index. Mitotic catastrophe detected immunofluorescence. tested using intracranial U87 glioma model.We biologic effects...
Individuals with prehypertension are at risk of hypertension and cardiovascular diseases, yet efficient interventions lagging behind. Studies indicate that heart rate variability-biofeedback (HRV-BF) increases HRV baroreflex sensitivity (BRS) as well reduces related pathological symptoms, suggesting potentially beneficial effects HRV-BF on prehypertension, but little is known about these effects. In this study, were investigated their mechanisms explored.The effect in young adults its...
High Salinity is a major environmental stress influencing growth and development of rice. Comparative proteomic analysis hybrid rice shoot proteins from Shanyou 10 seedlings, salt-tolerant variety, Liangyoupeijiu salt-sensitive was performed to identify new components involved in salt-stress signaling. Phenotypic one protein that upregulated during salt-induced stress, cyclophilin 2 (OsCYP2), indicated OsCYP2 transgenic seedlings had better tolerance salt than did wild-type seedlings....
Genomic, transcriptional, and proteomic analyses of brain tumors reveal subtypes that differ in pathway activity, progression, response to therapy. However, a number small molecule inhibitors under development vary strength subset pathway-specificity, with molecularly targeted experimental agents tending toward stronger specificity. The Notch signaling is an evolutionarily conserved plays important role multiple cellular developmental processes. We investigated the effects inhibition glioma...
Tumor-targeted drug delivery systems have been increasingly used to improve the therapeutic efficiency of anticancer drugs and reduce their toxic side effects in vivo. Focused on this point, doxorubicin (DOX)-loaded hydroxyapatite (HAP) nanorods consisting folic acid (FA) modification (DOX@HAP-FA) were developed for efficient antitumor treatment. The DOX-loaded synthesized through situ coprecipitation hydrothermal method with a DOX template, demonstrating new procedure loading HAP materials....
The chloroplast genome is important for plant development and evolution. Nelumbo nucifera one member of relict plants surviving from the late Cretaceous. Recently, a new sequencing platform PacBio RS II, known as `SMRT (Single Molecule, Real-Time) sequencing', has been developed. Using SMRT to investigate N. will help elucidate plastid evolution basal eudicots. sizes de novo assembled complete were 163,307 bp, 163,747 bp 163,600 with average depths coverage 7×, 712× 105× sequenced by Sanger,...
A flexible approach is presented to generate vector beams with arbitrary polarization and complex amplitude by means of two cascaded transmissive liquid crystal spatial light modulators (LCSLMs). The configuration the LCSLM system its modulation characteristic are introduced. Theoretical analysis experimental demonstration prove that in combination a double-pass computer-generated hologram black-and-white pattern can respectively controlling amplitudes orthogonal components beams. Using this...
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality in China. This study aimed to develop a hyaluronic acid (HA) decorated, pH sensitive lipid-polymer hybrid nanoparticles (LPH NPs) co-deliver erlotinib (ERL) and bevacizumab (BEV) (HA-ERL/BEV-LPH for targeting suppressing NSCLC. HA contained nano-materials were synthesized by acylation reaction. HA-ERL/BEV-LPH NPs prepared using sonication method. To explore efficiency system, we evaluated physicochemical...
Artemisia argyi leaf polysaccharide (AALPs) were prepared through ultrasound-assisted extraction (UAE), and their antifatigue activities evaluated. Extraction was optimized using response surface methodology (RSM), which yielded the following optimal UAE conditions: ultrasonication power of 300 W, temperature 51 °C, liquid:solid ratio 20 mL/g, time 47 mins. The above conditions resulted in maximum rate 10.49 %. Compared with hot water (HWE), supported higher yields total sugar, uronic acid,...
Objective: Prehypertension is a new category designated by the Seventh Report of Joint National Committee on Prevention, Detection, Evaluation, and Treatment High Blood Pressure (JNC7) in 2003. Managing prehypertension with nonpharmacological intervention possibly beneficial to prevention hypertension. In this study, we observed effect slow abdominal breathing combined electromyographic (EMG) biofeedback training blood pressure (BP) prehypertensives assessed changes heart rate variability...
With the advent of high-throughput sequencing technologies, much progress has been made in identification somatic structural rearrangements cancer genomes. However, characterization complex alterations and their associated mechanisms remains inadequate. Here, we report a comprehensive analysis whole-genome DNA copy number data sets from The Cancer Genome Atlas to relate chromosomal imbalances dosage describe landscape intragenic breakpoints glioblastoma multiforme (GBM). Gene length,...