A5106574568- Mental Health Treatment and Access
- Childhood Cancer Survivors' Quality of Life
- Spinal Fractures and Fixation Techniques
- Knee injuries and reconstruction techniques
- Fibroblast Growth Factor Research
- Erythropoietin and Anemia Treatment
- Cancer Genomics and Diagnostics
- Substance Abuse Treatment and Outcomes
- Schizophrenia research and treatment
- Steroid Chemistry and Biochemistry
- Acute Lymphoblastic Leukemia research
- Migraine and Headache Studies
- Industrial Vision Systems and Defect Detection
- Total Knee Arthroplasty Outcomes
- Acute Myeloid Leukemia Research
- Spine and Intervertebral Disc Pathology
- Cancer therapeutics and mechanisms
- Esophageal Cancer Research and Treatment
- Enzyme Catalysis and Immobilization
- Dementia and Cognitive Impairment Research
- Thermography and Photoacoustic Techniques
- Orthopaedic implants and arthroplasty
- Pharmacological Effects and Toxicity Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Neurological Disorders and Treatments
Southwest Medical University
2021-2025
Beijing Anding Hospital
2024
Capital Medical University
2021-2024
Harbin Institute of Technology
2024
University of Washington Medical Center
2024
Fred Hutch Cancer Center
2024
Third Affiliated Hospital of Sun Yat-sen University
2023
Sun Yat-sen University
2023
University of Science and Technology of China
2023
Guangzhou University of Chinese Medicine
2022
Abstract Background New therapies are urgently needed for Alzheimer’s disease (AD). Sodium oligomannate (GV-971) is a marine-derived oligosaccharide with novel proposed mechanism of action. The first phase 3 clinical trial GV-971 has been completed in China. Methods We conducted 3, double-blind, placebo-controlled participants mild-to-moderate AD to assess efficacy and safety. Participants were randomized placebo or (900 mg) 36 weeks. primary outcome was the drug-placebo difference change...
Doxorubicin (DOX), a potent broad‑spectrum chemotherapeutic agent used for the treatment of several types cancer, is largely limited due to its serious side effects on non‑target organs. Thus, present study aimed investigate whether berberine (Ber), an isoquinoline alkaloid, could reduce DOX‑induced acute hepatorenal toxicity in rats. Fifty rats were randomly divided into five groups: i) Control group, ii) DOX iii) DOX+Ber (5 mg kg) group; iv) (10 kg), and v) (20 group. In tests, body...
Composite film materials offer several advantages, such as high strength-to-weight ratios, flexibility, durability, or cost-effectiveness, which make them ideal for a wide range of applications across various industries. However, microporous defects in the material compromise its durability and air-tightness. Thus far, few works have been performed on inquiring non-destructive testing methods intended detection composite materials. In this study, automatic is achieved by using thermal...
ABSTRACT Background Intervertebral disc degeneration (IDD) is a human aging disease related mainly to inflammation, cellular senescence, RNA/DNA methylation, and ECM. The mitogen‐activated protein kinase (MAPK) signaling pathway engaged in multiple biological functions by phosphorylating specific serine threonine residues on target proteins through phosphorylation cascade effects, but the role mechanisms of MAPK IDD are still unclear. Methods We identified 20 MAPK‐related differential genes...
Objective To compare medial pivot (MP) prostheses to two types of posterior‐stabilized (PS) (NexGen and NRG) in terms patient satisfaction, causes dissatisfaction, risk factors for dissatisfaction after total knee arthroplasty (TKA). Methods A 453 patients who underwent primary TKA by one senior surgeon from August 2016 2018 were investigated a retrospective study, including 121, 219, 113 the MP, NexGen, NRG groups, respectively. The mean age follow‐up time 70.82 ± 7.06 years 20.64 3.88...
While the incidence of esophageal adenocarcinoma (EAC) has risen drastically in Western countries over last 40 years, a similar trend not been observed for EAC China. Here, we analyzed mutational spectrum, copy number alterations, and structural variants from whole-genome sequencing 10 Chinese tumor samples their matched normal samples, compared them to previously reported specimens countries. The burden was significantly lower than that found hallmark A>C signature at high frequency...
This study aimed to elucidate the risk factors associated with alcohol use disorders (AUDs) among inpatients schizophrenia at a specialized mental hospital in Baoding city, China. cross-sectional survey comprised 301 comorbid patients. Three binary logistic regression models were used investigate linked AUDs patients schizophrenia. Propensity score matching analysis was conducted validate inconsistent variables identified by models. Significant differences observed between and non-comorbid...
Abstract Purpose Adipokines and inflammatory cytokines (ADICs) play important roles in type 2 diabetes mellitus (T2DM). This study aimed to compare the changes of ADIC levels (ΔADICs) patients with newly diagnosed T2DM treated different antihyperglycemic agents, further investigate impact these on metabolic indices, β-cell function insulin resistance (IR). Methods Four hundred sixteen from 25 centers China randomly received 48-week intervention exenatide, or pioglitazone. Anthropometric...
Effects of continuing nursing mode were studied in elderly home patients with chronic renal failure. Eighty five failure randomly divided into an experimental group (41 cases) and control (43 cases). Patients the given conventional discharge guidance health education, those implemented by team. The results showed that scores on self-care skills, sense responsibility, self-concept knowledge before significantly improved compared after (P 0.05), but third month higher than at admission...
Abstract Objective Our objective was to systematically evaluate the efficacy and safety of Banxia Baizhu Tianma decoction in treatment migraine. Methods The databases China National Knowledge Infrastructure, VIP, WanFang, Chinese Biomedical Databases, PubMed, EMbase were searched by computer, randomized controlled trials that met inclusion criteria retrieved. Cochrane bias risk assessment tool used quality included studies. RevMan 5.3 software conduct meta quantitative analysis Results A...
Abstract Background: The posterior fixation system (PFS) is extensively used in the treatment of spinal diseases. However, fixation-induced pathological stress distribution pattern (e.g., concentration and motility compensation) will increase risk adjacent segment diseases (ASD). accurate adjustment insertional screw positions possible under guidance C-arm during percutaneous pedicle insertion. Although studies reported that would affect stiffness fusion segment, there were still no...