A5103245763- Gout, Hyperuricemia, Uric Acid
- Cancer survivorship and care
- Family Support in Illness
- Acute Ischemic Stroke Management
- Dementia and Cognitive Impairment Research
- Tryptophan and brain disorders
- Inflammatory Biomarkers in Disease Prognosis
- Inflammasome and immune disorders
- Traditional Chinese Medicine Studies
- Stroke Rehabilitation and Recovery
- Cancer-related cognitive impairment studies
- Balance, Gait, and Falls Prevention
- Vitamin D Research Studies
- Hepatitis B Virus Studies
- S100 Proteins and Annexins
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Advanced Neuroimaging Techniques and Applications
- Health and Wellbeing Research
- Obstructive Sleep Apnea Research
- Cerebral Palsy and Movement Disorders
- Bipolar Disorder and Treatment
- Viral gastroenteritis research and epidemiology
- Body Image and Dysmorphia Studies
- Eating Disorders and Behaviors
- Cerebrovascular and Carotid Artery Diseases
Wenzhou Medical University
2015-2023
First Affiliated Hospital of Wenzhou Medical University
2015-2023
Second Xiangya Hospital of Central South University
2023
Shenzhen Pingle Orthopedic Hospital
2008
Zhejiang Sci-Tech University
2008
Abstract Background New therapies are urgently needed for Alzheimer’s disease (AD). Sodium oligomannate (GV-971) is a marine-derived oligosaccharide with novel proposed mechanism of action. The first phase 3 clinical trial GV-971 has been completed in China. Methods We conducted 3, double-blind, placebo-controlled participants mild-to-moderate AD to assess efficacy and safety. Participants were randomized placebo or (900 mg) 36 weeks. primary outcome was the drug-placebo difference change...
Abstract Introduction Low serum vitamin D levels are associated with the development of poststroke depression (PSD). Inflammatory markers play an important role in pathophysiology PSD. The relationship between and inflammatory has been discussed nonstroke individuals. purposes this study were to explore acute stroke patients examine effect on Methods A total 152 recruited. Serum 25‐hydroxyvitamin measured by standardized laboratory methods. Depression symptoms assessed 17‐item Hamilton Scale...
Patients with breast cancer usually present varying levels of depressive symptoms. Emotional suppression, as a coping style, refers to an individual's ability consciously control expression negative emotions. Thus, emotional suppression is important psychological factor related symptoms in patients cancer. It has long been considered that compared European and American women, Chinese women are more likely ascribe norms emotion for smooth social interaction. However, there paucity research...
The prevalence and factors associated with delays in help seeking for people dementia China are unknown.Within 1,010 consecutively registered participants the Clinical Pathway Alzheimer's Disease (CPAD) study (NCT01779310), 576 persons (PWDs) their informants reported estimated time from symptom onset to first medical visit diagnosis. Univariate analysis of general linear model was used examine potential delayed diagnosis seeking.The median duration noticeable or treatment 1.77 years....
The study aimed to explore latent profiles of coping in Chinese women newly diagnosed with breast cancer and examine the differences psychological distress, demographic, medical characteristics across profiles.Latent profile analysis was used identify 3 classes copers based on data from 618 who completed questionnaires assessing their strategies distress."Adaptive coper," reporting most use adaptive cognitive strategies, behaviors acceptance shifting attention, least maladaptive had best...
Poststroke depression (PSD) is a frequent complication of stroke that has been associated with poorer outcome patients. This study sought to examine the possible association between serum uric acid levels and development PSD. We recruited 196 patients acute ischemic 100 healthy volunteers. Serum were tested by uricase-PAP method within 24 hr after admission. Neuropsychological evaluations conducted at 3-month poststroke. The 17-item Hamilton Depression Scale was used assess depressive...
Whether leukoaraiosis burden retards short-term recovery after minor stroke is unclear. We investigated the association between and early of neurological function a first ischemic in 217 acute patients (National Institutes Health Stroke Scale (NIHSS) score ≤5). Leukoaraiosis severity was graded according to Fazekas scale categorized into none mild (0–2; n = 143) or severe (3–6; 74) groups. NIHSS Minimum Mental State Examination (MMSE) were assessed at baseline 30 days. Univariate analysis...
Background Major depression (MD) is caused by a combination of genetic and environmental factors. In this study we investigated the interaction variations in G-protein beta 3 subunit (GNB3) cAMP response element binding protein 1 (CREB1) genes with negative life events pathogenesis MD. One GNB3 polymorphism (rs5443) four CREB1 polymorphisms (rs2253206, rs2551941, rs6740584, rs11904814) were based on known associations Methods 512 patients MD 513 control subjects genotyped. The frequency...
Abstract Objective High levels of mean platelet volume (MPV) had been found in depression subjects. We sought to examine the relationship between MPV and poststroke (PSD). Methods One hundred eighty‐five patients with acute ischemic stroke were enrolled our study. Peripheral venous blood samples drawn at admission measured by automated hematology analyzer. Patients a HAMD‐17 score >7 diagnosed as having PSD. Results that 60 (32.4%) developed PSD, PSD significantly higher (9.3 ± 1.8 fl)...
Background: Braking force is a gait marker associated with stability. This study aimed to determine the alteration of braking and its correlation stability in Alzheimer disease (AD). Methods: A total 32 AD patients healthy controls (HCs) were enrolled this study. Gait parameters (braking force, variability, fall risk) walking tests Free walk, Barrier, Count backward measured by JiBuEn® analysis system. variability was calculated coefficient variation (COV) stride time, stance swing time....
Post-stroke fatigue (PSF) is a frequent complication of stroke. Serum uric acid (SUA) frequently thought to be risk factor for This study aimed investigate whether SUA also played role in PSF.Subjects with ischemic stroke were screened from The First Affiliated Hospital Wenzhou Medical University between January 2020 and October 2020. Patients' symptoms assessed by the Fatigue severity scale (FSS). To relationship PSF, binary logistic regression analysis was conducted, confounders being...
Sleep disorders are prevalent after stroke, resulting in high recurrence rates and mortality. But the biomarkers of sleep stroke patients remain to be elucidated. This study aimed explore relationship between total bilirubin-to-uric acid ratio (TUR) quality acute ischemic (AIS).Three hundred twenty-six AIS were recruited followed up 1 month our study. Serum bilirubin uric levels obtained within 24 h admission. The Pittsburgh Quality Index (PSQI) was used evaluate stroke. We conducted...
Post-stroke anxiety (PSA) is serious psychosomatic comorbidity among patients with stroke, but whether obesity could be positively associated PSA currently unknown. The purpose of this study was to investigate the potential association between and subsequent risk in stroke. A total 441 acute ischemic stroke (AIS) onset were consecutively recruited within 7 days, post-stroke depression (PSD) evaluated by using a 14-item Hamilton scale (HAMA) 17-item (HAMD) at end 1-month follow-up. odds ratio...
Post-stroke anxiety (PSA) is a common neuropsychiatric affective disorder occurring after stroke. Animal experiments have indicated that serum S-100β levels are closely related to disorder. No clinical study has been done explore the relationship between and symptoms in patients with acute The aim of our was investigate association PSA.One hundred twenty-six stroke were recruited followed up for 1 month. Blood samples collected within 24 h admission. measured by enzyme-linked immunosorbent...
Objective: To investigate the feasibility of isolation and culture human adenoid-derived mesenchymal stem cells (aMSCs) in vitro, to observe differentiation aMSCs into olfactory sensory neurons. Methods: Adenoid tissues surgically removed from children with adenoid hypertrophy Second Xiangya Hospital Central South University September November 2020 were collected. The digested isolated by trypsin then cultured adhesion method. expressions cell surface antigens CD45, CD73 CD90 on P5...