Refractory wound healing is one of the most common complications diabetes. Excessive production reactive oxygen species (ROS) can cause chronic inflammation and thus impair cutaneous healing. Scavenging these ROS in dressing may offer effective treatment for wounds. Here, a nanocomposite hydrogel based on alginate positively charged Eudragit nanoparticles containing edaravone, an efficient free radical scavenger, was developed maximal sequestration. enhanced edaravone solubility stability...

In recent decades, researchers and clinicians have sought to determine how improve the quality of life (QOL) women with breast cancer. Previous research has shown that many particular behavioral coping styles, which are important determinants QOL. As behavior is closely associated cognition, these patients may also cognitive styles. However, characteristics their effects on QOL in cancer remain unclear. Thus, this study aimed characterize styles among explore emotion regulation strategies...

Complex molecular details of transcriptional regulation can be coarse-grained by assuming that reaction waiting times for promoter-state transitions, the mRNA synthesis, and degradation follow general distributions. However, how such a generalized two-state model is analytically solved long-standing issue. Here we first present analytical formulas burst-size distributions this model. Then, derive an iterative equation moment-generating function, which raw binomial moments any order...

Abstract Macrocyclization has enabled the use of peptides in drug discovery creating a need for methods to synthesize diverse peptide macrocycles. Azapeptides have advanced clinically used drugs, however, few cyclic azapeptides been studied. A multiple component “A 3 ‐macrocyclization” strategy is described preparation and demonstrated by synthesis 15 growth hormone releasing hormone‐6 (GHRP‐6) analogs. Certain aza‐GHRP‐6 analogs exhibited unprecedented affinity CD36 receptor, capacity...

Structural mimics comprising 1,4- and 1,5-disubstituted triazole-containing cyclic tripeptides with excellent resemblance toward the DE-ring of vancomycin are conveniently accessible using Cu(I)- or Ru(II)-assisted "click" cyclization.

Herein we report the Ru(II)-catalyzed double-macrocyclization of a hexapeptide to obtain mimic bicyclic CDE-ring vancomycin, followed by measurement its binding affinity for small peptide ligands using ITC.

This study aimed to investigate anxiety sensitivity (AS) in female Chinese nurses better understand its characteristics and relationship with nursing stress based on the following hypotheses: (1) experienced have higher AS than newly admitted nurses; (2) specific stresses are associated after controlling general stress.The cross-sectional survey was conducted from May 2014 June 2015 among at provincial primary care levels Hunan Province, China.Among 793 who volunteered participate, 745...

Patients with breast cancer usually present varying levels of depressive symptoms. Emotional suppression, as a coping style, refers to an individual's ability consciously control expression negative emotions. Thus, emotional suppression is important psychological factor related symptoms in patients cancer. It has long been considered that compared European and American women, Chinese women are more likely ascribe norms emotion for smooth social interaction. However, there paucity research...

Transforming growth factor β (TGFβ) is a multifunctional cytokine which importantly implicated in hepatocarcinogenesis. The current study provides novel evidence that TGFβ upregulates the expression of multiple receptor tyrosine kinases (RTKs), including IGF1R, EGFR, PDGFβR, and FGFR1 human hepatocellular carcinoma (HCC) cells. This, turn, sensitized HCC cells to individual cognate RTK ligands, leading cell survival. Our data showed TGFβ-mediated increase sensitivity led evasion apoptosis...

Cationic antimicrobial peptides (CAMPs) are potent therapeutics for drug-resistant bacterial infections. However, the clinical application of CAMPs is hampered by its poor proteolytic stability and hemolytic activity toward eukaryotic cells. Great efforts have been made to design generate derivatives with improved pharmacological properties. Here, we report a novel stapling protocol, which tethers two ε-amino groups lysine residue N-alkylation reaction on hydrophilic face amphiphilic...

Abstract Ginsenoside Rb 1 is an active protopanaxadiol saponin from Panax species. In order to compare the similarities and differences of microbial mammalian metabolisms ginsenoside , transformation by Acremonium strictum metabolism in rats were comparatively studied. Microbial AS 3.2058 resulted formation eight metabolites. Ten metabolites (M1–M10) detected vivo study them identified as same compounds those obtained liquid chromatography–tandem mass spectrometry analysis comparison with...

// Wenhu Liu 1, 2, 3 , Jinxia Chang 4 Mingwei 2 Jiangbei Yuan 1 Jinqiang Zhang Jun Qin 5, 6 Xuefeng Xia and Yi Wang School of Pharmaceutical Sciences Innovative Drug Research Center, Chongqing University, 401331, China State Key Laboratory Proteomics, National Center for Protein Sciences, Beijing Proteome 102206, Pharmacy, North Sichuan Medical College, Nanchong 637007, Basic 5 Verna Marrs McLean Department Biochemistry Molecular Biology, Baylor College Medicine, Houston, Texas 77030, USA...

Cationic antimicrobial peptides (CAMPs) are promising for treatment of multidrug-resistant (MDR) bacteria-caused infections. However, clinical application CAMPs has been hampered mostly due to their poor proteolytic stability and hemolytic toxicity. Recently, lysine-stapled developed by us had proved increase peptide in vitro without induction hemolysis. Herein, the applicability lysine stapling strategy was further explored using five natural or artificial as model peptides. Lysine...

Dibenzo-24-crown-8-based cryptand 4 forms 1:1 inclusion complexes with three paraquat derivatives, P1, P2, and P3, as demonstrated by proton NMR spectroscopy X-ray analysis. However, it was found that methyl-substituted P2 can bind more strongly than non-methyl-substituted derivative P1. The association constants (Ka) were determined in acetone using a UV-vis titration method to be 5.0 x 10(3) M(-1) for 4.P1, 1.0 10(5) 4.P2, 1.2 4.P3, respectively. In the solid state, 4.P2 4.P3 have similar...

Copper catalyzed coupling of Mannich reagents to aza-propargylglycine residues has been employed synthesize constrained aza-lysine peptides. Employing growth hormone releasing peptide-6 (GHRP-6) as a model peptide and variety secondary amines, 18 aza-Lys analogs were synthesized by this so-called A3-coupling reaction. This effective method for making aza-Lys-peptides offers strong potential exploring various recognition events implicating lysine including post-translational modification.

A novel salamo-like copper(<sc>ii</sc>) complex probe (<bold>ASC</bold>) behaves as a two-pronged sensor of S₂O₃²⁻ions and GSH by ‘turn-on’ fluorescence mechanism.

Abstract Two [3]rotaxanes were synthesized from two bis( m ‐phenylene)‐32‐crown‐10‐based cryptands and a bisparaquat derivative by using threading‐followed‐by‐stoppering method. As result of strong association positive cooperative complexation between the derivative, high yields selectivities achieved. No [2]rotaxanes found during preparation.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2008)

γ-secretase inhibitors (GSIs) have been developed to reduce amyloid-β (Aβ) production for the treatment of Alzheimer's disease by inhibiting cleavage amyloid precursor protein (APP). However, cross-inhibitory activity on processing Notch can cause adverse reactions. To avoid these undesirable effects, modulators (GSMs) are being selectively toxic Aβ without perturbing signaling. As it is also known that GSIs a paradoxical increase plasma over baseline after transient reduction (known as...

Although miR-150 is implicated in the regulation of immune cell differentiation and activation, it remains unknown whether involved liver biology disease. This study was performed to explore potential role LPS/D-GalN Fas-induced injuries by using wild type knockout (KO) mice. Whereas did not significantly alter LPS/D-GalN-induced animal death injury, protected against injury mortality. The Jo2-induced increase serum transaminases, apoptotic hepatocytes, PARP cleavage, as well caspase-3/7,...

Antimicrobial peptides (AMPs) have attracted great attention as next generation antibiotics for the treatment of multidrug-resistant (MDR) bacterial infections. Poor proteolytic stability has however undermined clinical applications AMPs. A novel peptide cyclization approach is described to enhance in vivo antibacterial activity Bicyclic antimicrobial were synthesized by cross-linking ε-amino groups three lysine residues with a 1,3,5-trimethylene benzene spacer. In proof principal study,...

The solid‐phase synthesis of azapeptides possessing a C‐terminal aza‐residue has been accomplished by protocol featuring regioselective alkylation benzhydrylidene‐aza‐glycinamide and illustrated the syntheses [aza‐Lys 6 ] growth‐hormone‐releasing peptide‐6 analogs. Copyright © 2015 European Peptide Society John Wiley &amp; Sons, Ltd.