A5100416919- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Ferroptosis and cancer prognosis
- Sarcoma Diagnosis and Treatment
- Crystallography and molecular interactions
- Lung Cancer Treatments and Mutations
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Advanced biosensing and bioanalysis techniques
- Lung Cancer Research Studies
- Sulfur Compounds in Biology
- Respiratory Support and Mechanisms
- Tryptophan and brain disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer, Lipids, and Metabolism
- Neonatal Respiratory Health Research
- Health disparities and outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Metastasis and carcinoma case studies
- Molecular Sensors and Ion Detection
Fudan University
2010-2025
Wenzhou Medical University
2021-2025
Shanxi Medical University
2017-2025
First Affiliated Hospital of Wenzhou Medical University
2023-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2023-2025
Guangzhou University of Chinese Medicine
2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Xi'an Jiaotong University
2018-2025
Ministry of Education of the People's Republic of China
2025
Shaanxi Provincial People's Hospital
2025
Abstract Background Activated astrocytes play important roles in chronic post-surgical pain (CPSP). Recent studies have shown reactive are classified into A1 and A2 phenotypes, but their precise CPSP remain unknown. In this study, we investigated the of spinal cord related mechanisms CPSP. Methods We used a skin/muscle incision retraction (SMIR) model to establish rat model. Microglia, CXCR7, phosphoinositide 3-kinase/Akt (PI3K/Akt) signaling pathways were regulated by intrathecal injections...
Accumulating evidence has demonstrated that up-regulation of the angiotensin (Ang)-converting enzyme (ACE)/AngII/AngII type 1 receptor (AT1R) axis aggravates pulmonary fibrosis. The recently discovered ACE2/Ang-(1-7)/Mas axis, which counteracts activity ACE/AngII/AT1R been shown to protect against However, mechanisms by ACE2 and Ang-(1-7) attenuate fibrosis remain unclear. We hypothesized protects bleomycin (BLM)-induced inhibiting mitogen-activated protein kinase (MAPK)/NF-κB pathway. In...
Poly(d,l-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PLGA–PEG–PLGA) was synthesized via ring-opening polymerization of d,l-lactide and glycolide in the presence poly(ethylene glycol) (PEG), then a series triblock copolymers with different molar-mass dispersities (ĐMs) under similar weight-average molecular weight (Mw) or number-average (Mn) were obtained step precipitation mixing given PEG length varied PLGA lengths. The effects distribution (MWD) on...
Abstract Cardiovascular complications contribute to the major mortality and morbidity in type 2 diabetes. Diabetic cardiomyopathy (DCM) is increasingly recognized as an important cause of heart failure. EMPA-REG OUTCOME trial has reported that empagliflozin, sodium-glucose cotransporter inhibitor, exerts cardiovascular benefits on diabetic population. However, mechanism by which empagliflozin alleviates DCM still remains unclear. In current study, we investigated cardiac protective effects...
Autoimmune hepatitis (AIH) is increasingly affecting human health but pharmacotherapies remain to be identified. Growing evidence reveals that ferroptosis, a newly recognized form of programmed cell death, critical for AIH. However, the exact mechanisms ferroptotic cascade elusive. Data in this study showed ferroptosis aggravation was associated with protectively-elevated fibroblast growth factor 4 (FGF4) expression Concanavalin A (ConA)-induced AIH liver injury, these effects being...
Gastric cancer (GC) is a prevalent malignant of digestive system. To identify key genes in GC, mRNA microarray GSE27342, GSE29272, and GSE33335 were downloaded from GEO database. Differentially expressed (DEGs) obtained using GEO2R. DAVID database was used to analyze function pathways enrichment DEGs. Protein-protein interaction (PPI) network established by STRING visualized Cytoscape software. Then, the influence hub on overall survival (OS) performed Kaplan-Meier plotter online tool....
Angiogenesis plays an essential role in the progression of rheumatoid arthritis (RA). RGD peptide shows high affinity and selectivity for integrin αvβ3, which is one most extensively examined target angiogenesis. Nimesulide could improve anti-rheumatic profile methotrexate. But clinical application was limited due to water-insolubility both methotrexate nimesulide lacking targeting ability. Therefore, this study aimed design a targeted drug delivery system micelles mediated by plus passive...
Although numerous studies have indicated that chronic stress causes cognitive dysfunction with the impairment of synaptic structures and functions, relationship between deficits induced by repeated restraint level NMDA receptors in subregion hippocampus has been relatively unknown until now. In this study, 3-week-old male Sprague-Dawley rats were exposed to for seven consecutive days, their functions evaluated through behavioral tests, then they sacrificed electrophysiological,...
Background: Abnormal tau accumulation in the brain has a positively correlation with neurodegeneration and memory deterioration, but mechanism underlying tau-associated synaptic cognitive impairments remains unclear. Our previous work found that human full length (hTau) activated signal transducer activator of transcription-1 (STAT1) to suppress N-methyl-D-aspartate receptors (NMDARs) expression, followed by deficits. STAT3 also belongs STAT protein family is reported involve regulation...
Central post-stroke pain (CPSP) is a chronic and intolerable neuropathic syndrome following cerebral vascular insult, which negatively impacts the quality of life stroke survivors but currently lacks efficacious treatments. Though its underlying mechanism remains unclear, clinical features hyperalgesia allodynia indicate central sensitization due to excessive neuroinflammation. Recently, crosslink between neuroinflammation endoplasmic reticulum (ER) stress has been identified in diverse...
Background: The incidence of cerebral ischemia disease leading cause death in human population worldwide. Treatment remains a clinical challenge for researchers and mechanisms remain unknown. During the ischemia, inflammatory reaction oxidative stress plays an important role. current investigation scrutinized neuroprotective anti-inflammatory role pterostilbene against middle artery occlusion (MCAO) rodent model explore underlying mechanism. Methods: rats were divided into following groups...
Simple summary Studies have shown that about 30% of kidney cancer patients will metastasis, and lymph node metastasis (LNM) may be related to a poor prognosis. Our retrospective study aims provide reliable machine learning-based model predict the occurrence LNM in cancer. We screened pathological grade, liver M staging, primary site, T tumor size from training group (n=39016) formed by SEER database validation (n=771) medical center. Independent predictors patients. Using six different...
A diblock copolymer of methoxy poly(ethylene glycol) and poly(DL-lactide-co-glycolide) (MPEG–PLGA) was synthesized via ring-opening polymerization. Its aqueous system over the critical gelation concentration underwent a gel-to-sol transition with increasing temperature. More interestingly, gel-to-sol-to-(reentrant gel) transitions upon heating were found in presence salts. The reentrant gel virgin exhibited different viscoelasticities, as revealed by dynamic rheological measurements,...
Apatinib (YN968D1) is a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR-2). We conducted single-arm, nonrandomized phase II study (NCT03121846) to assess the efficacy and safety of apatinib in patients with stage IV sarcoma. recruited 64 sarcoma who had failed chemotherapy. The primary endpoint was progression-free survival (PFS), secondary endpoints were rate (PFR), objective response (ORR), disease control (DCR) at week 12. Treatment-related...
The multidimensional features of intergenerational relationships and the mixed feelings among parents with multiple children complicate how shape mental health older parents. This study explores patterns Chinese families their associations parents' depressive symptoms.Through 3 waves (2014, 2016, 2018) nationally representative longitudinal data obtained from China Longitudinal Aging Social Survey (CLASS), we used k-means clustering method fixed-effects models to address research...
Cardiovascular risk burden is associated with dementia and neurodegeneration-related brain structure, while the role of genetics incident cardiovascular disease (CVD) remains unclear. To examine association overall major subtypes volumes related regions in a large sample, to explore CVD onset. A prospective study among 354 654 participants free (2006-2010, mean age 56.4 years) was conducted within UK Biobank, magnetic resonance imaging (MRI) measurement available for 15 104 since 2014....
Abstract A universal platform is developed for dropletizing single cell plate‐based multiomic assays, consisting of three main pillars: a miniaturized open Heterogeneous Hydrogel reactor (abbreviated HetHydrogel) multi‐step biochemistry, its tunable permeability that allows Tn5 tagmentation, and droplet barcoding. Through optimizing the HetHydrogel manufacturing procedure, chemical composition, permeation conditions, simultaneous high‐throughput mitochondrial DNA genotyping chromatin...