A5066745753- Cyclopropane Reaction Mechanisms
- Catalytic Alkyne Reactions
- Asymmetric Synthesis and Catalysis
- Fluorine in Organic Chemistry
- Chemical Synthesis and Reactions
- Synthetic Organic Chemistry Methods
- Proteoglycans and glycosaminoglycans research
- Nitric Oxide and Endothelin Effects
- Natural product bioactivities and synthesis
- Carbon dioxide utilization in catalysis
- Sulfur-Based Synthesis Techniques
- Oxidative Organic Chemistry Reactions
- Genomics, phytochemicals, and oxidative stress
- Synthesis and biological activity
- Neuroinflammation and Neurodegeneration Mechanisms
- Synthesis and Reactions of Organic Compounds
- Synthesis and Catalytic Reactions
- Skin Protection and Aging
- Neurological Disease Mechanisms and Treatments
- Chemical Synthesis and Analysis
- Caveolin-1 and cellular processes
- Crystallization and Solubility Studies
- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Organometallic Complex Synthesis and Catalysis
Shanghai Institute of Technology
2016-2025
Guangxi University of Chinese Medicine
2024
Wuyi University
2024
Kuaishou (China)
2023
Chang'an University
2023
Baoshan College
2023
Fujian Agriculture and Forestry University
2022
Green Technology
2022
Fluor (United States)
2022
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2022
In the presence of catalytic amounts sodium iodide, triphenylphosphine, and phenol, carbon dioxide can efficiently react with epoxides to give corresponding five-membered cyclic carbonates in high yields. The mechanism this reaction was disclosed by (31)P NMR spectroscopic data deuterium labeling experiments.
[reaction: see text] The attempted aza-Baylis-Hillman reaction of N-tosylated imines with ethyl 2,3-butadienoate or penta-3,4-dien-2-one gave azetidine derivatives in the presence DABCO. In case 2,3-butandieonate catalyzed by DMAP, novel dihydropyridine were formed.
Background and purpose: Silymarin, a standardized extract of the milk thistle seeds, has been widely used to treat chronic hepatitis, cirrhosis, other types toxic liver damage. Despite increasing studies on action silymarin its major active constituent, silybin in their therapeutic properties against insulin resistance, diabetes hyperlipidaemia vitro vivo, mechanism underlying remains unclear. Experimental approach: C57BL/6 mice were fed high-fat diet (HFD) for 3 months induce obesity,...
Background: The incidence of cerebral ischemia disease leading cause death in human population worldwide. Treatment remains a clinical challenge for researchers and mechanisms remain unknown. During the ischemia, inflammatory reaction oxidative stress plays an important role. current investigation scrutinized neuroprotective anti-inflammatory role pterostilbene against middle artery occlusion (MCAO) rodent model explore underlying mechanism. Methods: rats were divided into following groups...
Methylenecyclopropanes (MCPs) 1 can react with aldehydes and aldimines to give the corresponding indene, THF, pyrrolidine cycloaddition products in presence of BF3·OEt2 under mild reaction conditions.
[reactions: see text] Manganese(III)-mediated oxidative annulation of methylenecyclopropanes with 1,3-dicarbonyl compounds in acetic acid produces 4,5-dihydrofuran derivatives as [3+2] products moderate to good yields under mild conditions. The possible reaction mechanism is discussed on the basis previous mechanistic investigation.
New six C6-celastrol derivatives were designed, synthesized, and evaluated for their in vitro cytotoxic activities against nine human cancer cell lines (BGC-823, H4, Bel7402, H522, Colo 205, HepG2 MDA-MB-468). The results showed that most of the compounds displayed potent inhibition BGC823, with IC50s 1.84–0.39 μM. best compound NST001A was tested an vivo antitumor assay on nude mice bearing 205 xenografts, significant tumor growth at low concentrations. Therefore, celastrol C-6 are...
Abstract The use of polymer‐supported Lewis bases such as PEG 4600 ‐(PPh 2 ) and poly(DMAP) in the Baylis–Hillman reactions N ‐tosylimines (ArCHNTs) 1 or corresponding arenecarbaldehydes with α,β‐unsaturated ketones has been investigated. adducts are obtained good yields. can be easily recovered by filtration base reproduced reduction LiAlH 4 CeCl 3 .
Methylenecyclopropanes (MCPs 1) react with aldehydes, N-tosyl aldimines, and acetals to give the corresponding indene, THF, pyrrolidine cycloaddition products in presence of BF3 x OEt2 under mild reaction conditions. Some special transformations MCPs 1 aldehydes have been reported this paper. A plausible mechanism has discussed, which is based on a deuterium-labeling experiment Prins-type mechanism.
Ultra Violet (UV) radiation induces reactive oxygen species (ROS) production, DNA oxidation and single strand breaks (SSBs), which will eventually lead to skin cell damages or even cancer. Here, we tested the potential activity of gremlin, a novel vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) agonist, against UV-induced damages. We show that gremlin activated VEGFR2 significantly inhibited death apoptosis keratinocytes fibroblasts. Pharmacological inhibition shRNA-mediated...
Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients who undergo surgery involving anesthesia. Its underlying mechanisms remain unclear. Autophagy plays an important role the damage and repair of nervous system associated with development POCD. Using rat model, adenosine monophosphate-activated protein kinase α1 (AMPKα1), autophagy regulator, was found to be significantly downregulated rats POCD that induced by sevoflurane anesthesia or appendectomy....
[reaction: see text] Pd(PPh3)4-catalyzed isomerization of MCPs 1 in acetic acid proceeds smoothly at 80 degrees C toluene to give the corresponding 1-substituted or 1,1-disubstituted dienes 2 good excellent yields under mild conditions. The plausible mechanism has been disclosed on basis a deuterium-labeling experiment.
Background: Although there have been many magnetic resonance spectroscopy (MRS) studies of migraine, few focused on migraines during an attack. Here, we aimed to assess metabolite changes in the brain patients with both attack and interictal phase. Methods: Six (one man five women, mean age: 39 ± 10 years) migraine without aura (MWoA-DA), 13 (three men 31 9 period (MWoA-DI), healthy controls (HC) (four nine were studied. All subjects underwent MRS examination focusing occipital lobe....
Two new steroid saponins, named terrestrinins A (1) and B (2), along with six known compounds were isolated from the Chinese medicine herb Tribulus terrestris, their chemical structures elucidated as 26-O-beta-D-glucopyranosyl-(25S)-furostan-4(5),20(22)-diene-3,12-dione 26-O-beta-D-glucopyranosyl-(25S)-5alpha-furostane-3beta,22alpha,26-triol-3-O-beta-D-xylopyranosyl(1 --> 3)-[(beta-D-xylopyranosyl(1 2)]-beta-D-glucopyranosyl(1 4)-[alpha-L-rhamnopyranosyl(1 2)]-beta-D-galactopyranoside (2) on...
A new class of C(6)-indole substituted celastrol derivatives were designed and synthesized. Among all these synthesized molecules, compound<bold>4f</bold>and<bold>4h</bold>displayed excellent<italic>in vitro</italic>antiproliferative activities against Bel7402 cancer cells.
To investigate the effects of liraglutide combined with insulin on oxidative stress and expression levels serum monocyte chemoattractant protein-1 (MCP-1) nuclear factor-kB (NF-kB) in patients type 2 diabetes.An experimental study.Department Endocrinology, Second Hospital Affiliated to Lanzhou University, China, from September 2016 January 2018.Ninety-two diabetes were selected as objects study. They randomly divided into observation group control group, 46 cases each group. The was treated...
Melanoma is known as the most aggressive and lethal type of cutaneous cancer due to its rapid development drug resistance chemotherapy drugs.In our study, we conducted a variety studies, including quantitative PCR, Western blot, autophagy apoptosis assays investigate involvement miR-26a HMGB1 in modulation dabrafenib sensitivity human melanoma cell lines.Our studies revealed that expressions were altered two lines after treatment. Additionally, caused this autophagic process was regulated by...