Chronic pain conditions are difficult to treat and major health problems. Bone marrow stromal cells (BMSCs) have generated considerable interest as a candidate for cell-based therapy. BMSCs readily accessible easy isolate expand ex vivo. Clinical studies show that direct injection of does not produce unwanted side effects is well tolerated safe. Here, we single systemic (intravenous) or local (into the lesion site) rat primary reversed hypersensitivity in rats after injury effect lasted...

Studies on peroxisome proliferator-activated receptor (PPAR)-γ ligands have been focused agonists. However, PPARγ activation may induce obesity and nonalcoholic fatty liver disease (NAFLD), one of the most challenging medical conditions. Here, we identified that isorhamnetin, a naturally occurring compound in fruits vegetables metabolite quercetin, is novel antagonist PPARγ. Isorhamnetin treatment inhibited adipocyte differentiation induced by agonist rosiglitazone, reduced development...

Background and purpose: Silymarin, a standardized extract of the milk thistle seeds, has been widely used to treat chronic hepatitis, cirrhosis, other types toxic liver damage. Despite increasing studies on action silymarin its major active constituent, silybin in their therapeutic properties against insulin resistance, diabetes hyperlipidaemia vitro vivo, mechanism underlying remains unclear. Experimental approach: C57BL/6 mice were fed high-fat diet (HFD) for 3 months induce obesity,...

Objective To investigate the effects of ilex kudingcha C. J. Tseng (kuding tea), a traditional beverage in China, on metabolic disorders C57BL/6 mice induced by high-fat diets. Design For preventive experiment, female were fed with standard diet (Chow), (HF), and mixed 0.05% ethanol extract kuding tea (EK) for 5 weeks. therapeutic 3 months, then split EK was given oral gavages 2 weeks at 50 mg/day/kg. Body weight daily food intake amounts measured. At end treatment, adipocyte images assayed...

Rheum palmatum has been used most frequently in the weight-reducing formulae traditional Chinese medicine. However, components of that play antiobesity role are still uncertain. Here, we tested effect two major compounds on db/db mouse. We found rhein (100 mg kg(-1) day(-1)), but not emodin, reduced fat weight Using diet-induced obese (DIO) C57BL/6 mice, identified blocked high-fat obesity, decreased mass and size white brown adipocytes, lowered serum cholesterol, LDL fasting blood glucose...

The number and variety of bitter compounds originating from plants are vast. Whereas some chemicals toxic should not be ingested, other exhibit health beneficial effects, which is manifest in the cross‐cultural believe that bitterness medicine correlated with desired medicinal activity. taste receptors oral cavity serve as sensors for and, they expressed numerous extraoral tissues throughout body, may also responsible physiological effects exerted by compounds. Chinese herbal uses herbs...

In recent years, although several studies have demonstrated the potential of graphene-coated substrates in promoting attachment, proliferation and differentiation osteoblasts mesenchymal stem cells (MSCs), effects single-layer graphene on osteogenic human MSCs (hMSCs) remains unclear, especially vivo. this study, we transferred chemical vapor deposition (CVD) grown to glass slides observed its adhesion, adipose-derived (hASCs) bone marrow (hBMMSCs) vitro. Then, vivo, incubated hASCs hBMMSCs...

In recent years, dental implants have become the preferred approach for restoration of missing teeth. At present, most are made pure titanium, and affected by peri-implantitis bone resorption, which usually start from implant neck, due to complex environment in this region. To address these issues, study we modified surface titanium (Ti) exploit antibacterial osteoinductive effects single-layer graphene sheets. Chemical vapor deposition (CVD)-grown sheets were transferred discs, a method...

Background and Purpose The molecular mechanism for the pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains elusive. Both farnesoid X receptor (FXR) signalling endoplasmic reticulum (ER) stress contribute to progression NAFLD; however, it is not clear whether actions these two pathways are dependent on each other. Moreover, pharmacological benefits betulinic acid (BA) in controlling metabolic syndrome NAFLD largely unknown. Experimental Approach A reporter assay a time‐resolved...

ObjectiveMetabolic syndrome is a serious health problem in both developed and developing countries. The present study investigated the anti-metabolic disorder effects of different pomelo varieties on obese C57BL/6 mice induced by high-fat (HF) diet. DesignThe peels four were extracted with ethanol total phenols flavonoids content these extracts measured. For animal experiment, female fed Chow diet or HF alone supplemented 1% (w/w) peel for 8 weeks. Body weight food intake measured every...

Introduction Obesity is a nutritional disorder associated with many health problems such as dyslipidemia, type 2 diabetes and cardiovascular diseases. In the present study, we investigated anti-metabolic effects of kumquat (Fortunella margarita Swingle) fruit extract (FME) on high-fat diet-induced C57BL/6 obese mice. Methods The was extracted ethanol main flavonoids this were analyzed by HPLC. For preventive experiment, female mice fed normal diet (Chow), (HF), 1% (w/w) (HF+FME) for 8 weeks....

Breast cancer is the most prevalent malignant neoplasm among women worldwide.Despite continuous improvement of breast individualized comprehensive therapy, local recurrence and distant metastasis still remain challenges due to development acquired drug-resistance.Long non-coding RNAs (LncRNAs) known participated in cancer.However, mechanisms LncRNAs involving drug-resistance during chemotherapy be further elucidated.Aiming screen for candidate responsible mechanism, we first investigated...

Polygonatum odoratum (Mill.) Druce belongs to the genus family of plants. In traditional Chinese medicine, root odoratum, Rhizoma Polygonati Odorati, is used both for food and medicine prevent treat metabolic disorders such as hyperlipidemia, hyperglycemia, obesity cardiovascular disease. However, there no solid experimental evidence support these applications, underlying mechanism also needed be elucidated. Here, we examined effect extract Odorati (ER) on in diet-induced C57BL/6 obese mice....

Background and Purpose Morin is a natural occurring flavonoid in many dietary plants has wide range of beneficial effects on metabolism; however, the mechanism underlying its action remains elusive. Experimental Approach A reporter assay time‐resolved FRET were used to identify morin as dual antagonist liver X receptor (LXR)‐α ‐β. (100 mg . 100 g ‐1 diet) was administered high‐fat diet‐induced obese or LXRβ −/− mice. The pharmacological evaluated by Western blot RT‐PCR analyses. Key Results...

The growing enthusiasm for cancer immunotherapies and adoptive cell therapies has prompted increasing interest in biomaterials development mimicking natural antigen-presenting cells (APCs) T-cell expansion. In contrast to conventional bottom-up approaches aimed at layering synthetic substrates with activation cues, transformation of live dendritic (DCs) into artificial APCs (aAPCs) is demonstrated herein using a facile minimally disruptive hydrogelation technique. Through direct...

Abstract Background LanGui tea, a traditional Chinese medicine formulation comprising of Gynostemma pentaphyllum (Thunb.) Makino, Cinnamomum cassia (L.) J. Presl, and Ampelopsis grossedentata (Hand-Mazz) W.T. Wang, has yet to have its potential contributions alcoholic liver disease (ALD) fully elucidated. Consequently, the objective this research is investigate protective properties tea against binge alcohol-induced ALD mechanisms underlying effects. Methods An experimental model acute was...

Obesity is a common nutritional disorder associated with type 2 diabetes, cardiovascular diseases, dyslipidemia, and certain cancers. In this study, we investigated the effects of Citrus ichangensis peel extract (CIE) in high-fat (HF) diet-induced obesity mice. Female C57BL/6 mice were fed chow diet or an HF alone supplemented 1% w/w CIE for 8 weeks. We found that treatment could lower blood glucose level improve tolerance. HF+CIE group, body weight gain, serum total cholesterol (TC)...

Wax gourd is a popular vegetable in East Asia. In traditional Chinese medicine, wax peel used to prevent and treat metabolic diseases such as hyperlipidemia, hyperglycemia, obesity, cardiovascular disease. However, there no experimental evidence support these applications. Here, we examined the effect of extract (EWGP) on disorders diet-induced C57BL/6 obese mice. preventive experiment, EWGP blocked body weight gain lowered serum total cholesterol (TC), low-density lipoprotein (LDL-c), liver...

Natural dual farnesyl X receptor (FXR)/G protein-coupled bile acid 1 (TGR5) activators have received little attention in the management of metabolic diseases. Deoxyschizandrin (DS), a natural lignan, occurs S. chinensis fruit and has potent hepatoprotective effects, whereas its protective roles mechanisms against obesity non-alcoholic fatty liver disease (NAFLD) are largely elusive. Here, we identified DS as FXR/TGR5 agonist using luciferase reporter cyclic adenosine monophosphate (cAMP)...