A5007605702- Photonic and Optical Devices
- Animal Virus Infections Studies
- Advanced Photonic Communication Systems
- Viral gastroenteritis research and epidemiology
- Photonic Crystals and Applications
- Influenza Virus Research Studies
- Optical Network Technologies
- SARS-CoV-2 and COVID-19 Research
- Semiconductor Quantum Structures and Devices
- Semiconductor Lasers and Optical Devices
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Viral Infections and Vectors
- Patient Safety and Medication Errors
- Biosensors and Analytical Detection
- Cancer-related molecular mechanisms research
- Simulation-Based Education in Healthcare
- Integrated Circuits and Semiconductor Failure Analysis
- interferon and immune responses
- Mosquito-borne diseases and control
- Clinical Reasoning and Diagnostic Skills
- Arsenic contamination and mitigation
- RNA Interference and Gene Delivery
- Respiratory viral infections research
- Nanoplatforms for cancer theranostics
National Taiwan University
2016-2025
Taipei Medical University
2002-2025
Taiwan Agricultural Research Institute Council of Agriculture, Executive Yuan
2025
National Cheng Kung University Hospital
2019-2024
Chang Gung University
2006-2024
National Yang Ming Chiao Tung University
2011-2024
Jinan University
2023
University of South China
2023
Kagoshima University
2021-2022
Nanjing Forestry University
2022
Influenza A virus (IAV) neuraminidase (NA) cleaves sialic acids (Sias) from glycans. Inhibiting NA with oseltamivir suppresses both viral infection, and release cultured human airway epithelial cells. The role of in exit is well established: it releases budding virions by cleaving Sias glycoconjugates on infected cells progeny virions. entry remains unclear. Host respiratory epithelia secrete a mucus layer rich heavily sialylated glycoproteins; these could inhibit mimicking receptors the...
The continued threat of emerging, highly lethal infectious pathogens such as Middle East respiratory syndrome coronavirus (MERS-CoV) calls for the development novel vaccine technology that offers safe and effective prophylactic measures. Here, a nanoparticle is developed to deliver subunit viral antigens STING agonists in virus-like fashion. are first encapsulated into capsid-like hollow polymeric nanoparticles, which show multiple favorable attributes, including pH-responsive release...
Improving the resuscitation and teamwork skills of residents is key to better outcomes in-hospital cardiac arrest events. This study aims explore effects regular low-dose simulation combined with a booster workshop on progression retention among residents. comparative took place at teaching hospital in Northern Taiwan from August 2019 June 2021. Residents were divided into two groups: control group received faculty-led debriefing 1st, 6th, 11th months, while intervention participated an...
In this paper, we review the hybrid silicon photonic integration platform and its use for optical links. platform, a III/V layer is bonded to fully processed silicon-on-insulator wafer. By changing bandgap of quantum wells (QW), low-threshold-current lasers, high-speed modulators, photodetectors can be fabricated operating at wavelengths 1.55 μm. With QW intermixing technology, these components integrated with each other complete interconnect realized on-chip. The bonding process technology...
The device and integration technology for silicon photonic transmitters are reviewed in this paper. hybrid platform enables on-chip lasers to be fabricated with circuits can integrated the CMOS back-end flow. Laser arrays from multiple die bonding quantum well intermixing techniques demonstrated extend spectral bandwidth laser array of transmitter. Two modulator technologies, modulators modulators, also described.
Kawasaki disease (KD), an acute febrile vasculitis, is the most common cause of acquired heart in childhood; however, diagnosing KD can be difficult.To identify unique proteomic biomarkers that used to facilitate earlier diagnosis KD.We enrolled 214 children with fever and clinical features suggestive KD. Of those, only 100 were diagnosed Their plasma samples globally analyzed for cytokines, chemokines, cell adhesion molecules using unbiased, large-scale, quantitative protein array. This...
Infection with one of the four dengue virus serotypes (DENV1-4) presumably leads to lifelong immunity against infecting serotype but not heterotypic reinfection, resulting in a greater risk developing Dengue Hemorrhagic Fever/Dengue Shock Syndrome (DHF/DSS) during secondary infection. Both antibodies and T cell responses have been implicated DHF/DSS pathogenesis. According cell-based hypothesis termed "original antigenic sin," DENV infection is dominated by non-protective, cross-reactive...
We have demonstrated a traveling-wave electroabsorption modulator based on the hybrid silicon platform. For device with 100 μm active segment, small-signal electro/optical response renders 3 dB bandwidth of around 42 GHz and its modulation efficiency reaches 23 GHz/V. A dynamic extinction ratio 9.8 driving voltage swing only 2 V was at transmission rate 50 Gb/s. This represents significant improvement for modulators compatible integration silicon-based photonic integrated circuits.
We investigated the roles of IFN regulatory factor (IRF)-3 and IRF-7 in innate antiviral immunity against dengue virus (DENV). Double-deficient Irf-3(-/-)7(-/-) mice infected with DENV2 strain S221 possessed 1,000-150,000 fold higher levels viral RNA than wild-type single-deficient 24 h postinfection (hpi); however, they remained resistant to lethal infection. IFN-α/β was induced similarly Irf-3(-/-) post-DENV infection, whereas Irf-7(-/-) mice, significantly low expression observed within...
Attachment to cellular surfaces is a major attribute among infectious pathogens for initiating disease pathogenesis. In viral infections, viruses exploit receptor-ligand interactions latch onto exterior prior subsequent entry and invasion. light of the selective binding affinity between cells, nanoparticles cloaked in membranes are herein employed virus targeting. Using influenza as model, erythrocyte membrane prepared modified with magnetic functionalities (RBC-mNP) targeting isolation. To...
Feline infectious peritonitis (FIP), caused by a mutated feline coronavirus, is one of the most serious and fatal viral diseases in cats. The disease remains incurable, there no effective vaccine available. In light pathogenic mechanism coronavirus that relies on endosomal acidification for cytoplasmic entry, novel vacuolar ATPase blocker, diphyllin, its nanoformulation are herein investigated their antiviral activity against type II virus (FIPV). Experimental results show diphyllin...
Several microbes, including Staphylococcus epidermidis (S. epidermidis), a Gram-positive bacterium, live inside the human nasal cavity as commensals. The role of these commensals in host innate immunity is largely unknown, although bacterial interference microbiome may promote ecological competition between commensal bacteria and pathogenic species. We demonstrate here that S. culture supernatants significantly suppressed infectivity various influenza viruses. Using high-performance liquid...
Photoacoustic tomography emerged as a promising tool for noninvasive biomedical imaging and diseases diagnosis. However, most of the current piezoelectric ultrasound transducers suffer optical opacity tissue-mismatched acoustic impedance, hindering miniaturization integration system multiscale multimodal imaging. Here, transparent polydimethylsiloxane (PDMS) encapsulated microfiber sensor was demonstrated photoacoustic with scalable spatial resolution penetration depth. The comprised loop...
A new way to make high speed modulators using Si waveguides is demonstrated. The hybrid silicon evanescent electroabsorption modulator with offset AlGaInAs quantum wells has an extinction ratio over 10 dB and modulation bandwidth of GHz. a clean open eye at Gb/s sub-volt drive.
In this work we report a separate-absorption-charge-multiplication Ge/Si avalanche photodiode with an enhanced gain-bandwidth-product of 845 GHz at wavelength 1310 nm. The corresponding gain value is 65 and the electrical bandwidth 13 optical input power -30 dBm. unconventional high investigated using device physical simulation pulse response measurement. analysis electric field distribution, electron hole concentration drift velocities in shows that bias voltages due to decrease transit...
A hybrid silicon photonic integrated filter is proposed and demonstrated with a novel structure. This incorporates ring resonator in one arm of Mach-Zehnder interferometer making it possible to obtain programmable response. The optical consists 5-mm-long delay loop made low-loss waveguides thermal modulators resulting 0.164-nm free spectral range absolute phase tunability gain elements that allow for the tuning factor. microwave response this measured display 20 GHz.
Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection Che-Ming Jack Hu,1,2,* You-Ting Chen,3,* Zih-Syun Fang,1,3 Wei-Shan Chang,3 Hui-Wen Chen2,3 1Institute Biomedical Sciences, Academia Sinica, Taipei, Taiwan; 2Research Center for Nanotechnology and Infectious Diseases, 3Department Veterinary Medicine, National Taiwan University, *These authors contributed equally to this work Background: Influenza infections are a major public health concern...
Adenosine-to-inosine RNA editing constitutes a crucial component of the cellular transcriptome and critically underpins organism survival development. While recent high-throughput approaches have provided comprehensive documentation editome, its functional output remains mostly unresolved, particularly for events in non-coding regions. Gene ontology analysis known targets unveiled preponderance genes related to apoptosis regulation, among which proto-oncogenes XIAP MDM2 encode two most...