A5100350530- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Acute Kidney Injury Research
- Bladder and Urothelial Cancer Treatments
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Microtubule and mitosis dynamics
- Immunotherapy and Immune Responses
- Photosynthetic Processes and Mechanisms
- Cancer-related Molecular Pathways
- Chronic Kidney Disease and Diabetes
- Plant Molecular Biology Research
- Metabolomics and Mass Spectrometry Studies
- Antibiotic Resistance in Bacteria
- Breast Cancer Treatment Studies
- Sepsis Diagnosis and Treatment
- Microbial Metabolism and Applications
- Breast Lesions and Carcinomas
- Ferroptosis and cancer prognosis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Heilongjiang Provincial Hospital
2025
Harbin Medical University
2024-2025
First Affiliated Hospital of Harbin Medical University
2024-2025
Education Department of Heilongjiang Province
2024-2025
Sichuan Agricultural University
2022-2025
CSL (Australia)
2025
Yan'an University
2025
Shenzhen Second People's Hospital
2017-2024
Shenzhen Institutes of Advanced Technology
2024
Chinese Academy of Sciences
2022-2024
The continued threat of emerging, highly lethal infectious pathogens such as Middle East respiratory syndrome coronavirus (MERS-CoV) calls for the development novel vaccine technology that offers safe and effective prophylactic measures. Here, a nanoparticle is developed to deliver subunit viral antigens STING agonists in virus-like fashion. are first encapsulated into capsid-like hollow polymeric nanoparticles, which show multiple favorable attributes, including pH-responsive release...
Abstract Background Sepsis-associated acute kidney injury (SA-AKI) is a frequent complication in patients with sepsis and associated high mortality. Therefore, early recognition of SA-AKI essential for administering supportive treatment preventing further damage. This study aimed to identify validate metabolite biomarkers assist clinical diagnosis. Methods Untargeted renal proteomic metabolomic analyses were performed on the tissues LPS-induced mice. Glomerular filtration rate (GFR)...
Honokiol (HKL) has been reported to ameliorate lipopolysaccharide (LPS)-induced acute lung injury (ALI). However, its potential mechanism of protective effects remains unclear. In this study, the HKL on LPS-induced ALI was explored in vivo and vitro.In vivo, SD rats were intratracheally instilled with LPS (5 mg/kg) establish an model then treated (1.25/2.5/5 or ML385 (30 intraperitoneally. vitro, human bronchial epithelial cell line (BEAS-2B) stimulated ATP induce pyroptosis (12.5/25/50 μM)....
Summary Emodin, an anthraquinone compound extracted from rhubarb and other traditional Chinese medicines, has been proven to have a wide range of pharmacological effects, such as anti-inflammatory, antiviral, antitumor activities. Previous studies confirmed that emodin inhibitory effects on various solid tumors, osteosarcoma, liver cancer, prostate cancer glioma. This study aimed investigate the mechanisms emodin-induced necroptosis in glioma cell line U251 by targeting TNF-α/RIP1/RIP3...
Abstract Natural and artificial cells are two common chassis in synthetic biology. can perform complex tasks through genetic constructs, but their autonomous replication often causes safety concerns for biomedical applications. In contrast, based on nonreplicating materials, albeit possessing reduced biochemical complexity, provide more defined controllable functions. Here, the first time, authors create hybrid material‐cell entities termed Cyborg Cells. To Cells, a polymer network is...
Abnormal coagulation is a common feature of glioma. There strong correlation between and the complement system, named cascades (CCC). However, role CCC genes in lower-grade glioma (LGG) remains unclear. This study aimed to investigate LGG.
Abstract Introduction As proteins that promote immune cell differentiation, chemokines have attracted great interest regarding their role in anti-tumor responses within the cancer environment. However, exact of CXCL10, a chemokine, bladder (BLCA) is still not fully elucidated. Method In present study, we employed bioinformatics approaches to examine expression pattern, prognostic value, and infiltration CXCL10 BLCA. Furthermore, focused on examining impact therapy Additionally, validated...
Abstract Studies have revealed key genomic aberrations in pediatric acute myeloid leukemia (AML) based on Western populations. It is unknown to what extent the current findings represent populations with different ethnic backgrounds. Here we present landscape of driver alterations Chinese AML and discover previously undescribed aberrations, including XPO1 - TNRC18 fusion. Comprehensively comparing between cohorts reveal a substantially distinct alteration profile. For example, patients more...
Because the tumor-draining lymph nodes (TDLNs) microenvironment is commonly immunosuppressive, oncolytic microbe-induced tumor antigens aren't sufficiently cross-primed specific T cells through antigen-presenting (e.g., dendritic (DCs)) in TDLNs. Herein, this work develops micro-to-nano microbial therapeutics based on pyranose oxidase (P
Background Anoikis is a programmed cell death process that was proven to be associated with cancer. Uroepithelial carcinoma of the bladder (BLCA) malignant disease urinary tract and has strong metastatic potential. To determine whether anoikis-associated genes can predict prognosis BLCA accurately, we evaluated prognostic value in constructed best model prognosis. Method The transcriptome data were downloaded from TCGA GEO databases, differential expression selected then clustered using...
The filamentation temperature-sensitive H (FtsH) gene family is critical in regulating plant chloroplast development and photosynthesis. It plays a vital role growth, development, stress response. Although FtsH genes have been identified wide range of plants, there no detailed study the soybean (Glycine max). Here, we 34 GmFtsH genes, which could be categorized into eight groups, same group had similar structures conserved protein motifs. We also performed intraspecific interspecific...
Abstract Background Damage to the retinal vasculature is a major cause of vision loss and influenced by pro-inflammatory environment within tissue. Alpha-1 antitrypsin (AAT) potent inhibitor serine proteases has anti-inflammatory properties. We hypothesised that AAT could reduce inflammation vasculopathy in neovascular retinopathies including oxygen-induced retinopathy (OIR). Methods Litters C57BL/6J mice were randomised develop OIR exposure high oxygen between postnatal days 7 12 resulting...
miRNAs are a family of single-stranded non-coding RNAs that regulate gene expression by targeting messenger (mRNAs) for suppression, with an average length 22 nt. The oriental armyworm, Mythimna separata Walker, is pest insect long-distance migratory capability, which causes severe loss grains and pastures in Eastern Asia, Southeastern Oceania. This study aims to elucidate the post-transcriptional regulatory mechanisms development this pest. We carried out small RNA sequencing on samples...
ABSTRACT Sepsis is characterised by fatal organ dysfunction resulting from a dysfunctional host response to infection, imposing substantial economic burden on families and society. Therefore, identifying biomarkers for early sepsis diagnosis improving patient prognosis are critical. This study recruited 59 patients 35 healthy volunteers the Department of Critical Care Medicine at Harbin Medical University Affiliated First Hospital between March December 2021. Through combination non‐targeted...
Abstract Membrane‐lytic peptides offer broad synthetic flexibilities and design potential to the arsenal of anticancer therapeutics, which can be limited by cytotoxicity noncancerous cells induction drug resistance via stress‐induced mutagenesis. Despite continued research efforts on membrane‐perforating for antimicrobial applications, success in peptide therapeutics remains elusive given muted distinction between cancerous normal cell membranes challenge degradation neutralization upon...
Background: NUAKs promote myosin light chain phosphorlyation, actin organization, proliferation and suppression of cell death in non-muscle cells, which are critical for smooth muscle contraction growth. In benign prostatic hyperplasia (BPH), growth the prostate drive urethral obstruction voiding symptoms. However, a role or functions unknown. Here, we examined effects NUAK silencing presumed inhibitors, HTH01-015 WZ4003 on growth-related stromal cells (WPMY-1) human tissues. Methods:...
Abstract Targeting cancer‐specific metabolic processes is a promising therapeutic strategy. Here, this work uses compound library that directly inhibits enzymes to screen the potential targets in lung adenocarcinoma (LUAD). SHIN1, specific inhibitor of serine hydroxymethyltransferase 1/2 (SHMT1/2), has highly inhibitory effect on LUAD cells, and depends mainly overexpression SHMT2. This clarifies mitogen‐activated protein kinase 1 (MAPK1)‐mediated phosphorylation at Ser90 key mechanism...