A5030370296- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Urban Green Space and Health
- Protein Degradation and Inhibitors
- Land Use and Ecosystem Services
- Health, Environment, Cognitive Aging
- Genomics and Chromatin Dynamics
- Gene expression and cancer classification
- DNA Repair Mechanisms
- Urban Heat Island Mitigation
- Bioinformatics and Genomic Networks
- Scientific Computing and Data Management
- Immune Cell Function and Interaction
- Fungal and yeast genetics research
- Chronic Myeloid Leukemia Treatments
- Air Quality Monitoring and Forecasting
- Chromosomal and Genetic Variations
- Plant responses to elevated CO2
- earthquake and tectonic studies
- Air Quality and Health Impacts
Shanghai Jiao Tong University
2017-2025
Shanghai Children's Medical Center
2021-2025
National Earthquake Response Support Service
2024-2025
Peking University
2021-2024
Research Center for Eco-Environmental Sciences
2019-2024
Chinese Academy of Sciences
2019-2024
Center for Life Sciences
2024
Fujian University of Technology
2023-2024
Beijing Electronic Science and Technology Institute
2022-2023
Shanghai Institute of Hematology
2017-2023
Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify molecular subtypes NKTCL based on genomic structural alterations EBV sequences, we performed multi-omics study 128 biopsy samples newly diagnosed defined three prominent subtypes, which differ significantly in origin, gene expression, transcriptional signatures, responses to asparaginase-based regimens targeted...
Conserved chromosomal HP1 proteins capable of binding to histone H3 methylated at lysine 9 are believed provide a dynamic platform for the recruitment and/or spreading various regulatory involved in diverse processes. The fission yeast Schizosaccharomyces pombe family members Chp2 and Swi6 important heterochromatin assembly transcriptional silencing, but their precise roles not fully understood. Here, we show that associate with deacetylase (HDAC) protein complexes containing class I HDAC...
Significance To get more insights into the disease mechanism of T-cell acute lymphoblastic leukemia (T-ALL), particularly in an adult group, we addressed genomic landscape 130 patients, including 61 cases T-ALL. A number new genetic aberrations were identified using integrated transcriptome and analysis. Distinct T-ALL subgroups defined according to interplay among different abnormalities gene transcription patterns. Characterization features is valuable not only for a better understanding...
Understanding how complex networks of genes integrate to produce dividing cells is an important goal that limited by the difficulty in defining function individual genes. Current resources for systematic identification gene such as siRNA libraries and collections deletion strains are costly organism specific. We describe here integration profiling, a novel approach identify eukaryotic based upon dense maps transposon integration. As proof concept, we used Hermes generate library 360,513...
Ground-level ozone (O3) pollution has been a severe environmental and health problem for decades. The importance of biogenic volatile organic compounds (BVOCs) in the formation tropospheric photochemistry O3 highlighted, especially areas rapid urbanization. We conducted simultaneous measurements trace gases, including NO, NOX, O3, BVOCs (i.e., isoprene α-pinene), urban rural forest Beijing to determine relationships between them. results highlight differences terms ambient air concentrations...
Metabolic reprogramming plays an essential role on lymphoma progression. Dysregulation of glutamine metabolism is implicated in natural-killer T-cell (NKTCL) and tumor cell response to asparaginase-based anti-metabolic treatment.To understand the metabolomic alterations determine potential therapeutic target asparaginase, we assessed profile using liquid chromatography-mass spectrometry serum samples 36 NKTCL patients, integrated targeted metabolic analysis RNA sequencing 102 patients. The...
Abstract Studies have revealed key genomic aberrations in pediatric acute myeloid leukemia (AML) based on Western populations. It is unknown to what extent the current findings represent populations with different ethnic backgrounds. Here we present landscape of driver alterations Chinese AML and discover previously undescribed aberrations, including XPO1 - TNRC18 fusion. Comprehensively comparing between cohorts reveal a substantially distinct alteration profile. For example, patients more...
Abstract Background Intracranial germ cell tumors (IGCTs) are a rare group of malignancies that clinically classified as germinomas and nongerminomatous (NGGCTs). Previous studies have found somatic mutations involving the mitogen-activated protein kinase/mTOR signaling pathway common early events. However, comprehensive genomic understanding IGCTs is still lacking. Methods We established cohort including over 100 conducted transcriptomic sequencing. Results identified novel recurrent driver...
In Tetrahymena, HHT1 and HHT2 genes encode the same major histone H3; HHT3 HHT4 similar minor H3 variants (H3s), H3.3 H3.4. Green fluorescent protein (GFP)-tagged is deposited onto chromatin through a DNA replication-coupled (RC) pathway. GFP-tagged H3.4 can be both by transcription-associated, replication-independent (RI) pathway also weakly an RC Although types of H3s pathway, repair synthesis associated with meiotic recombination utilizes specifically. The regions distinguishing for their...
Background Phosphorus (P) is an essential macronutrient for plant growth and development. Several genes involved in phosphorus deficiency stress have been identified various species. However, a whole genome understanding of the molecular mechanisms adaptations to low P remains elusive, there particularly little information on genetic basis these acclimations coniferous trees. Masson pine (Pinus massoniana) grown mainly tropical subtropical regions China, many which are severely lacking...
In comparison with conventional hydrological parameters such as water levels and temperatures, geochemical changes induced by earthquakes have become increasingly important. It should be noted that hydrogen (δ2H) oxygen isotopes (δ18O) offer the greatest potential precursor proxies of earthquakes. Here, we conducted high-resolution sampling (weekly, 59 samples), measuring consecutive δ2H δ18O at two sites WLY well SS spring in Yan-Huai Basin Beijing from June 2021 to 2022. During period this...
Abstract Background Epigenome-wide association studies (EWAS), which seek the between epigenetic marks and an outcome or exposure, involve multiple hypothesis testing. False discovery rate (FDR) control has been widely used for testing correction. However, traditional FDR methods do not use auxiliary covariates, they could be less powerful if covariates inform likelihood of null hypothesis. Recently, many covariate-adaptive have developed, but application these to EWAS data yet explored. It...
Abstract Purpose: The current stratification system for acute promyelocytic leukemia (APL) is based on the white blood cell (WBC) and platelet counts (i.e., Sanz score) over past two decades. However, borderlines among different risk groups are sometimes ambiguous, some patients, early death relapse remained challenges. Besides, with evolving of treatment strategy from all-trans-retinoic acid (ATRA) chemotherapy to ATRA–arsenic trioxide-based synergistic targeted therapy, precise molecular...
The COVID-19 pandemic has seriously increased depression prevalence among the public, including Chinese college students. However, many exercise cannot be performed as usual under stay-at-home order. This study was a 12-week three-arm randomized controlled trial using intention-to-treat principle, aiming to explore and compare feasibility effect of individual-based personalized aerobic-exercise resistance-training prescriptions on depressive symptoms in students, conclude with some...
The energy inside the Earth can not only be released outward through earthquakes and volcanoes but also used by humans in form of geothermal energy. Is there a correlation between different forms release? In this contribution, we perform detailed seismic research Beijing area. results show that resources belong to typical medium-low temperature sedimentary basin, some areas are controlled deep fault activities (e.g., Xiji well (No. 17)). heat sources upper mantle heat, radioactive granite,...
Abstract The Warburg effect, which excessively produce lactate, and transcriptional dysregulation are two hallmarks of tumors. However, the precise influence lactate on epigenetic modifications at a genome-wide level its impact gene transcription in tumor cells remain unclear. We conducted an analysis histone H3 lysine 18 lactylation (H3K18la) T-cell acute lymphoblastic leukemia (T-ALL). found increased H3K18la T-ALL compared to normal T modification is associated with cell proliferation....
In order to solve the problem of high missed rate camellia fruits and damage flower buds during vibratory picking, through study on biological characteristics tree, crown tree was divided into upper lower canopy at maximum diameter. A kind vibration plate type fruit picking machine designed. The structure working principle whole were described. Through analysis factors abscission, it is concluded that frequency, amplitude time are main affecting magnitude inertia force. preliminary research...
Fine particulate matter (PM2.5) exposure causes DNA mutations and abnormal gene expression leading to lung cancer, but the detailed mechanisms remain unknown. Here, analysis of genomic transcriptomic changes upon a PM2.5 exposure-induced human bronchial epithelial cell-based malignant transformed cell model in vitro showed that led APOBEC mutational signatures transcriptional activation APOBEC3B along with other potential oncogenes. Moreover, by analyzing profiles 1117 non-small cancers...
The Tetrahymena thermophila CNA1 gene encodes the centromeric H3, Cna1p. Green fluorescent protein (GFP)-tagged Cna1p localizes in micronuclei dots whose number and behavior during mitosis conjugation are consistent with centromeres. During interphase, Cna1p-GFP peripheral dots, suggesting centromeres associated nuclear envelope. Newly synthesized enters accumulates nucleoplasm. Its deposition at starts early S phase continues through most of phase. is required for vegetative cell growth....