A5114889897- Fungal Biology and Applications
- Catalytic C–H Functionalization Methods
- Traditional Chinese Medicine Studies
- Radical Photochemical Reactions
- Wheat and Barley Genetics and Pathology
- Polysaccharides and Plant Cell Walls
- Diet and metabolism studies
- Algal biology and biofuel production
- Catalytic Cross-Coupling Reactions
- Electrocatalysts for Energy Conversion
- Advanced Photocatalysis Techniques
- Biofuel production and bioconversion
- Microbial Natural Products and Biosynthesis
- Plant and animal studies
- Clostridium difficile and Clostridium perfringens research
- CO2 Reduction Techniques and Catalysts
- Mosquito-borne diseases and control
- Food composition and properties
- Adipose Tissue and Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Organoboron and organosilicon chemistry
- Oxidative Organic Chemistry Reactions
- Seaweed-derived Bioactive Compounds
- Genomics and Phylogenetic Studies
- Mycorrhizal Fungi and Plant Interactions
Sun Yat-sen University
2004-2025
University of Science and Technology of China
2024-2025
Shenzhen Second People's Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2025
Institute of Software
2011-2024
Microbiology Institute of Shaanxi
2021-2024
Google (United Kingdom)
2024
DeepMind (United Kingdom)
2024
Jiangsu University
2013-2024
Brock University
2024
Bicyclo[2.1.1]hexanes (BCHs) represent an intriguing class of structurally rigid hydrocarbons that can serve as the bioisosteres benzenoids in medicinal chemistry. Methods for synthesis BCHs are, however, limiting. Reported herein is a facile via strain-release-driven [2π + 2σ] cycloaddition bicyclo[1.1.0]butanes (BCBs) with alkenes facilitated by pyridine-boryl radical catalyst. The mild reaction conditions, broad substrate scope, and decent functional group tolerance this protocol render...
Varenicline, an effective smoking cessation medication, functions as α4β2 nicotinic acetylcholine receptor partial agonist. It indirectly affects the dopaminergic reward system by reducing withdrawal symptoms during abstinence and decreasing reinforcement received from nicotine while smoking. We hypothesize that varenicline would have a third mechanism to blunt responses cues in reward-related ventral striatum medial orbitofrontal cortex be associated with reduction cue–elicited craving.A...
Carotenoid content is a primary determinant of wheat nutritional value and affects its end-use quality. Wheat grains contain very low carotenoid levels trace amounts provitamin A content. In order to enrich the in grains, bacterial phytoene synthase gene (CrtB) carotene desaturase (CrtI) were transformed into common cultivar Bobwhite. Expression CrtB or CrtI alone slightly increased transgenic wheat, while co-expression both genes resulted darker red/yellow grain phenotype, accompanied by...
Urolithin A (URA) is an intestinal microbiota metabolic product from ellagitannin-containing foods with multiple biological activities. However, its role in autoimmune diseases largely unknown. Here, for first time, we demonstrate the therapeutic effect of URA experimental encephalomyelitis (EAE) animal model.Therapeutic was evaluated via active and passive EAE model vivo. The function on bone marrow-derived dendritic cells (BM-DCs), T cells, microglia were tested vitro.Oral (25 mg/kg/d)...
Abstract Enzymatic electrosynthesis has gained more and interest as an emerging green synthesis platform, particularly for the fixation of CO 2 . However, simultaneous utilization a nitrogenous molecule enzymatic value‐added products never been reported. In this study, we constructed in vitro multienzymatic cascade based on reductive glycine pathway demonstrated electrocatalytic system that allowed conversion NH 3 sole carbon nitrogen sources to synthesize glycine. Through effective coupling...
Abstract Background Methanomassiliicoccales are a recently identified order of methanogens that diverse across global environments particularly the gastrointestinal tracts animals; however, their metabolic capacities defined via limited number cultured strains. Results Here, we profile and analyze 243 genomes assembled from representatives uncultured metagenomes recovered various biomes, including different animal species. Our analyses reveal presence numerous undefined genera genetic...
BACKGROUND. Current methods for detecting esophageal cancer (EC) are generally invasive or exhibit limited sensitivity and specificity, especially the identification of early-stage tumors.
Seed is vital to the conservation of germplasm and plant biodiversity. dormancy an adaptive trait in numerous seed-plant species, enabling plants survive under stressful conditions. mainly controlled by abscisic acid (ABA) gibberellin (GA) can be classified as primary secondary seed dormancy. The induced maternal ABA. Here we found that AtPER1, a seed-specific peroxiredoxin, involved enhancing Two loss-of-function atper1 mutants, atper1-1 atper1-2, displayed suppressed accompanied with...
Background and purpose: Silymarin, a standardized extract of the milk thistle seeds, has been widely used to treat chronic hepatitis, cirrhosis, other types toxic liver damage. Despite increasing studies on action silymarin its major active constituent, silybin in their therapeutic properties against insulin resistance, diabetes hyperlipidaemia vitro vivo, mechanism underlying remains unclear. Experimental approach: C57BL/6 mice were fed high-fat diet (HFD) for 3 months induce obesity,...
This research aimed to explore the interaction between lotus root polysaccharides (LRPs) and phenolic compounds, study effects of binding on structural functional properties LRPs. The influences pH, temperature, NaCl phenol concentration ratio gallic acid (GA)/epigallocatechin (EGC) LRPs were evaluated. LRP-GA/EGC complexes with different amounts then prepared characterized via ultraviolet–visible (UV–Vis) Fourier-transform infrared (FTIR) spectroscopy, average molecular weight (MW)...
The exploration of C(sp3)-rich three-dimensional (3D) scaffolds as bioisosteres for planar aromatics has garnered increasing attention. While the bioisosterism benzenes been extensively studied, pyridines, second most prevalent aromatic compounds in pharmaceuticals, faces additional challenges and encountered surprisingly limited success. In this study, we propose unprecedented 2-azabicyclo[3.1.1]heptenes effective 1,3,5-trisubstituted pyridines terms not only 3D conformation but also...
It is difficult to genetically manipulate the medically and biotechnologically important genus Clostridium due existence of restriction modification (RM) systems. We identified engineered RM system a model clostridial species, C. acetobutylicum, with aim allow host accept unmethylated DNA efficiently. A gene CAC1502 putatively encoding type II endonuclease Cac824I was from genome acetobutylicum DSM1731, disrupted using ClosTron based on group intron insertion. The resulting strain SMB009...
ObjectivesTo investigate the anti-Helicobacter pylori activity of 28 strains Lactobacillus salivarius and 12 other lactobacilli, isolated from different sites geographical regions.
For internal alkenes possessing two or more sets of electronically and sterically similar allylic protons, the site-selectivity for C-H functionalization is fundamentally challenging. Previously, negative inductive effect from an electronegative atom has been demonstrated to be effective several inspiring regioselective reactions. Yet, use electropositive a purpose remains developed. α-Aminoboronic acids their derivatives have found widespread applications. Their current syntheses rely...