A5100330058- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Pituitary Gland Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Photosynthetic Processes and Mechanisms
- Antioxidant Activity and Oxidative Stress
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Mycobacterium research and diagnosis
- Growth Hormone and Insulin-like Growth Factors
- Phagocytosis and Immune Regulation
- Diet and metabolism studies
- Sepsis Diagnosis and Treatment
- Plant biochemistry and biosynthesis
- Pharmacology and Obesity Treatment
- Neuropeptides and Animal Physiology
- Nanoplatforms for cancer theranostics
- Effects and risks of endocrine disrupting chemicals
First Affiliated Hospital of Xiamen University
2024-2025
Tongji Hospital
2015-2024
Tongji University
2024
Peking University
2017-2024
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Beijing Jishuitan Hospital
2024
Capital Medical University
2024
Huazhong University of Science and Technology
2014-2023
-Di(2-ethylhexyl) phthalate (DEHP), a typical endocrine-disrupting chemical (EDC), is widely used as plasticizer. DEHP exposure in humans virtually ubiquitous, and those undergoing certain medical procedures can be especially high. In this study, we investigated whether developmental disrupted glucose homeostasis the rat was associated with early impairment endocrine pancreas. Pregnant Wistar rats were administered (1.25 6.25 mg·kg(-1)·day(-1)) or corn oil throughout gestation lactation by...
Carotenoid content is a primary determinant of wheat nutritional value and affects its end-use quality. Wheat grains contain very low carotenoid levels trace amounts provitamin A content. In order to enrich the in grains, bacterial phytoene synthase gene (CrtB) carotene desaturase (CrtI) were transformed into common cultivar Bobwhite. Expression CrtB or CrtI alone slightly increased transgenic wheat, while co-expression both genes resulted darker red/yellow grain phenotype, accompanied by...
Betatrophin has recently attracted increasing interests as a potential β-cell regenerative therapy in diabetes. However, differences betatrophin profiles patients with type 2 diabetes mellitus (T2DM) remain unclear. The objective of the study was to examine circulating levels subjects different glucose tolerance status and its correlation insulin resistance. Serum were measured using an ELISA age-, sex-, body mass index-, blood lipid-matched normal (n = 137), isolated impaired fasting 69),...
Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) related imbalance, Tau-hyperphosphorylation, and neuroinflammation, in which Aβ neuroinflammation can induce brain insulin resistance (IR). Gut microbiome disorder correlated with inflammation AD. As of yet, there are no effective treatments clinically. Thus, it focused on the potential benefit quercetin-3-O-glucuronide (Q3G), a pharmacologically active flavonol glucuronide, AD treatment regulating IR gut microbiome.
Increasing the provitamin A content in staple crops via carotenoid metabolic engineering is one way to address vitamin deficiency. In this work a combination of methods was applied specifically increase β-carotene wheat by engineering. Endosperm-specific silencing hydroxylase gene (TaHYD) increased 10.5-fold 1.76 μg g–1 endosperm. Overexpression CrtB introduced an additional flux into wheat, accompanied 14.6-fold 2.45 g–1. When "push strategy" (overexpressing CrtB) and "block (silencing...
This study aimed to examine the prevalence of psychological distress and corresponding risk factors among patients with breast cancer affected by outbreak coronavirus disease 2019 (COVID-19).This cross-sectional, survey-based, region-stratified was conducted from March 14 21, 2020. An online survey used collect basic characteristics cancer. The degree depression, anxiety, insomnia symptoms were assessed using Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder (GAD-7),...
Abstract Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) its human ortholog receptor, leukocyte (LILRB2), are immune-inhibitory receptors. However, their role in NASH pathogenesis is still unclear. Here, we demonstrate that PirB/LILRB2 regulates the migration macrophages during by binding with ligand angiopoietin-like protein 8 (ANGPTL8). Hepatocyte-specific...
Liraglutide, a modified form of glucagon-like peptide-1 (GLP-1), has been found to improve beta cell function in type 2 diabetes (T2DM). However, the effect liraglutide on under lipotoxic stress and underlying molecular mechanisms remain unclear. In present study, we investigated role PI3K/Akt/FoxO1 signaling liraglutide-involved protection high free fatty acids (FFAs) condition. The apoptosis, proliferation, insulin secretion capability MIN6 cells islets from C57BL/6J mice were evaluated...
Objectives To analyze and summarize the clinical characteristics, surgical outcomes, prognosis of elderly adults with pituitary adenomas ( PA s). Design Retrospective cohort study. Setting Tongji Hospital. Participants Individuals who underwent transsphenoidal surgery for s between 2009 2012 (N = 1,104). Measurements were divided into two age groups (≥65 <65), their complications, follow‐up data analyzed compared. Results The older group had longer duration symptoms. most common symptom...
Metastasis is one of the most threatening aspects cervical cancer. We developed a method to intraoperatively map primary tumor, metastasis and metastatic sentinel lymph nodes (SLNs), providing real-time intraoperative guidance in Methods: TMTP1, tumor targeting peptide, was employed modify indocyanine green (ICG)-loaded poly (ethylene glycol)- (lactic-co-glycolic acid) (PEG-PLGA) micelles. The cancer subcutaneous model lung were established determine active ICG-loaded TMTP1-PEG-PLGA micelles...
To investigate the relationship between metabolic score for insulin resistance (METS-IR) index and major adverse cardiac events (MACEs) to compare its ability predict MACEs with other IR indices including homeostatic model assessment (HOMA-IR) triglyceride glucose (TyG) index-related parameters.We conducted a cohort study enrolling 7,291 participants aged ≥40 years. Binary logistic regression restricted cubic splines were performed determine association METS-IR MACEs, receiver operating...
Betatrophin is regarded as a liver-produced hormone induced by insulin resistance (IR). However, it remains largely unknown how IR regulates betatrophin expression. To study whether could regulate expression and the corresponding molecular mechanisms, levels were examined in 6 vitro models which established using human hepatocytes L02 with different agents, including tumor necrosis factor-α, interleukin-1β, dexamethasone, palmitate, high glucose elevated only group. These results suggest...
ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 repeats, member 13) is primarily synthesized in liver. The biosynthesis of its physiological role placenta are not known.We used real-time polymerase chain reaction, immunohistochemistry, Western blotting analyses, as well proteolytic cleavage FRETS (fluorescent resonance energy transfers)-VWF73, to determine expression trophoblasts obtained from individuals normal pregnancy patients severe preeclampsia. We also...
The aim of the current study was to evaluate effect sustained physiologic increase ∼50 mg/dL in plasma glucose concentration on insulin secretion normal glucose-tolerant (NGT) subjects. Twelve NGT subjects without family history type 2 diabetes mellitus (T2DM; FH−) and 8 with T2DM (FH+) received an oral tolerance test two-step hyperglycemic clamp (100 300 mg/dL) followed by intravenous arginine bolus before after 72-h infusion. Fasting increased from 94 ± 142 4 for 72 h. First-phase (0–10...
To examine the relationship between plasma glucagon levels and insulin sensitivity secretion in obese subjects.Suppression of was examined 275 Hispanic Americans with varying glucose tolerance. All subjects received a 2-hour oral tolerance test (OGTT) subset (n = 90) had euglycemic hyperinsulinemic clamp. During OGTT, we quantitated suppression concentration, Matsuda index sensitivity, secretion/insulin resistance (disposition) index. Plasma compared quartiles beta-cell function.Fasting were...
Lycopene β-cyclase (LCYB) is a key enzyme catalyzing the biosynthesis of β-carotene, main source provitamin A. However, there no documented research about this cyclase gene's function and relationship with β-carotene content in wheat. Therefore, objectives study were to clone TaLCYB characterize its wheat grains. We also aimed obtain more information endogenous carotenoid biosynthetic pathway thus provide experimental support for metabolic engineering wheat.In present study, lycopene gene,...
OBJECTIVE Sodium–glucose cotransporter 2 (SGLT2) inhibition causes an increase in endogenous glucose production (EGP). However, the mechanisms are unclear. We studied effect of SGLT2 inhibitors on EGP subjects with type diabetes (T2D) and without (non-DM) kidney transplant recipients renal denervation. RESEARCH DESIGN AND METHODS Fourteen who received a (six T2D [A1C 7.2 ± 0.1%] eight non-DM 5.6 0.1%) underwent measurement [3-3H]glucose infusion following dapagliflozin (DAPA) 10 mg or...