A5101653018- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Clusterin in disease pathology
- Pituitary Gland Disorders and Treatments
- Cancer-related molecular mechanisms research
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Ferroptosis and cancer prognosis
- Adrenal and Paraganglionic Tumors
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Circular RNAs in diseases
- Ultrasound and Hyperthermia Applications
- Ultrasound in Clinical Applications
- Biomarkers in Disease Mechanisms
- Retinoids in leukemia and cellular processes
- Traumatic Brain Injury Research
- FOXO transcription factor regulation
- Cerebrospinal fluid and hydrocephalus
- Cancer Research and Treatments
Huazhong University of Science and Technology
2014-2025
Tongji Hospital
2014-2025
Hebei North University
2022-2024
Chinese General Hospital College of Nursing and Liberal Arts
2023
Chinese People's Liberation Army
2023
University of Alabama at Birmingham
2019-2022
Glioblastoma (GBM) is composed of heterogeneous tumor cell populations, including those with stem properties, termed glioma cells (GSCs). GSCs are innately less radiation sensitive than the bulk and believed to drive GBM formation recurrence after repeated irradiation. However, it unclear how adapt escape toxicity irradiation used in clinical practice. To identify important mediators adaptive radioresistance GBM, we generated radioresistant human mouse by exposing them repeat cycles...
Abstract Background Glioma stem-like cells (GSCs) are key drivers of treatment resistance and recurrence in glioblastoma (GBM). Phosphoglycerate dehydrogenase (PHGDH), a crucial enzyme the de novo serine synthesis pathway (SSP), is implicated tumorigenesis therapy across various cancers. However, its specific role GBM, particularly radioresistance, remains poorly understood. Methods In silico analysis GBM patient data assessed SSP enrichment PHGDH expression linked with tumor stemness....
Objectives To analyze and summarize the clinical characteristics, surgical outcomes, prognosis of elderly adults with pituitary adenomas ( PA s). Design Retrospective cohort study. Setting Tongji Hospital. Participants Individuals who underwent transsphenoidal surgery for s between 2009 2012 (N = 1,104). Measurements were divided into two age groups (≥65 <65), their complications, follow‐up data analyzed compared. Results The older group had longer duration symptoms. most common symptom...
Brainstem tumors are rare and extremely heterogeneous present significant challenges in surgical treatment. Thus, biopsies often set the foundation for diagnosis of brainstem tumors. Multimodal, image-guided, robot-assisted frameless stereotactic increasingly popular neurosurgery centers. This study aimed to compare safety, efficacy, duration Remebot (Remebot) tumor biopsy versus those frame-based biopsy.A retrospective analysis 33 patients with who underwent department from January 2016...
Abstract Background N6-methyladenosine (m6A) and 5-methylcytosine (m5C) are the main RNA methylation modifications involved in oncogenesis of cancer. However, it remains obscure whether m6A/m5C-related long non-coding RNAs (lncRNAs) affect development progression low grade gliomas (LGG). Methods We summarized 926 LGG tumor samples with RNA-seq data clinical information from The Cancer Genome Atlas Chinese Glioma Atlas. 105 normal brain Genotype Tissue Expression project were collected for...
Regarding the determination of biomechanical parameters in a reliable vitro cell model for diffuse axonal injury (DAI), our study aimed to demonstrate connections between those and secondary axotomy through examination morphological alterations under variety traumatic conditions. An DAI was established primary cultured mouse neurons by uniaxial mechanical stretching non-myelinated axons various conditions: strain (ε) = 5, 10, 20, 50%; time (t) 500, 100, 20 ms; rate ranging 0.1 25 s-1. Axonal...
Glioblastoma remains highly lethal due to its inevitable recurrence. Most of this recurrence is found locally, indicating that postsurgical tumor-initiating cells (TICs) accumulate at the tumor edge. These edge-TICs then generate local harboring new core lesions. Here, we investigated clinical significance edge-to-core (E-to-C) signature generating glioblastoma and sought identify central mediators.
Abstract Background Glioblastoma remains highly lethal due to its inevitable recurrence. This recurrence is found locally in most cases, indicating that post-surgical tumor-initiating cells (TICs) accumulate at tumor edge. These edge TICs then generate recurrent tumors harboring new core lesions. Here, we investigated the clinical significance of edge-to-core transition (ECT) signature causing glioblastoma and sought identify central mediators for ECT. Methods First, examined association...
To explore the performance of single or combined ultrasound (US) in diagnosing malignant breast lesions, and then compare results with a magnetic resonance imaging (MRI) aspect.
Objective:To explore the diagnostic value of American Society Radiology Thyroid Imaging Reporting and Data System（ACR-TIRADS） Chinese Nodule Ultrasound Malignant Risk Stratification（C-TIRADS） in nodular Hashimoto thyroiditis papillary thyroid carcinoma with thyroiditis. Methods:This retrospective analysis included 144 patients（204 nodules） accompanied by or under background confirmed surgical pathology examination First Affiliated Hospital Hebei North University from August 2018 to May 2021,...
Abstract Glioblastoma (GBM) is composed of heterogeneous tumor cell populations including those with stem properties, termed glioma cells (GSCs). GSCs are innately less radiation sensitive than the bulk and believed to drive GBM formation recurrence after repeated irradiation. However, it unclear how adapt escape toxicity irradiation used in clinical practice. To identify important mediators adaptive radioresistance, we generated radioresistant human mouse by exposing them cycles Surviving...
Abstract Many subtypes of brain tumors are highly malignant and resistant to chemo- radio- therapy. Tumor cells can shift their phenotype in response treatments, the so-called adaptive resistance. Adaptive resistance mechanisms still poorly understood, effective treatments have not yet been developed. To unveil such mechanisms, we developed unique new experimental models identify fractionated radiation tumors. We performed repeated irradiation (2-5Gy every 3-4 days, 3-6 weeks) on 6 human...
Objective To investigate the expression of aryl Hydrocarbon Receptor Interacting protein (AIP)gene mutations and relationship with clinical biochemical characteristics in human somatotropinomas. Methods From October 2009 to September 2012, 96 acromegaly or gigantism patients were diagnosed a single pituitary center, consistent treatment follow-up. Genomic DNA from tumor tissues was extracted sequenced. Clinical data retrospectively analyzed. Results Overall,55 patients(57.3%)had...
Objective To study the clinical significance of pseudocapsule in transsphenoidal microsurgery for pituitary microprolactinoma.Methods From March 2012 to May 2013,61 patients with microprolactinoma were prospectively grouped and treated pseudocapsule-based extracapsular microsurgery,and follow-up data retrospectively analyzed.Results All followedup 10 months average.59 cases (96 ％) regained regular menstruation,33 (94％) galactorrhea had relieved,15 experienced postoperative pregnancy.The...
Abstract Background: N6-methyladenosine (m6A) and 5-methylcytosine (m5C) are the main RNA methylation modifications involved in oncogenesis of cancer. However, it remains obscure whether m6A/m5C-related long non-coding RNAs (lncRNAs) affect development progression low grade gliomas (LGG). Methods: We summarized 926 LGG tumor samples with RNA-seq data clinical information from Cancer Genome Atlas Chinese Glioma Atlas. 105 normal brain Genotype Tissue Expression project were collected for...
Objective To investigate the features and surgical treatment of patients with intracranial hematoma caused by ruptured middle cerebral artery (MCA) aneurysms. Methods A total 823 MCA aneurysms were admitted to Department Neurosurgery, Tongji Hospital, Medical College, Huazhong University Science & Technology from January 2013 2017. Among them, 43 resulted in only without subarachnoid hemorrhage (SAH). Out patients, temporal lobe was reported 25, frontal 8 intracerebral...
Abstract The highly infiltrative nature of glioblastoma (GBM) underscores limited response to current therapies and subsequent unfavorable clinical outcome. Despite the gross total resection tumors located in enhancing lesions, GBMs inevitably recur from areas adjacent cavity that retains tumor cells with tumor-initiating capacity therapy resistant (glioma-initiating cells: GICs). Here, we identified, GBM tumors, two mutually-exclusive glioma-initiating cell subpopulations different regions...
Abstract Therapeutic interventions induce cell stress to trigger apoptosis in tumor cells. Specific cellular stressors, including those initiated by radio-chemotherapy, activate distinct pro-death proteins through a multitude of mechanisms. Apoptosis consists highly regulated pathways involving post-translational modifications and cleavage leading sequential inactivation the main processes e.g. cycle progression. Recently, we demonstrated that apoptotic bodies/ApoEVs GBM transfer...
Abstract Glioblastoma (GBM) is composed of a variety tumor cell populations including those with stem properties, known as glioma cells (GSCs). GSCs are innately less sensitive to radiation than the bulk and believed drive GBM formation recurrence following repeated irradiation. However, it unclear how adapt avoid toxicity irradiation used in clinical practice. We established radioresistant human mouse by exposing them rounds order uncover critical mediators adaptive radioresistance....