A5102021836- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Diabetes Management and Research
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Systemic Lupus Erythematosus Research
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Gout, Hyperuricemia, Uric Acid
- Growth Hormone and Insulin-like Growth Factors
- Chronic Kidney Disease and Diabetes
- Lipid metabolism and disorders
- Diabetes and associated disorders
- Alcohol Consumption and Health Effects
- Metabolism, Diabetes, and Cancer
- Inflammasome and immune disorders
- Traditional Chinese Medicine Analysis
- Diabetes Treatment and Management
- Diabetes Management and Education
- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Medical Research and Treatments
- Genetic Syndromes and Imprinting
- Hemodynamic Monitoring and Therapy
Nanjing University of Chinese Medicine
2016-2025
Zhejiang Chinese Medical University
2025
Nanjing University
2009-2024
Nanjing General Hospital of Nanjing Military Command
2024
Shandong First Medical University
2022-2024
First Hospital of China Medical University
2024
China Medical University
2024
Xuzhou Medical College
2024
Shandong Provincial Hospital
2024
Shenzhen Luohu People's Hospital
2024
Summary Infection of hepatitis B virus ( HBV ) occurs in ~10% infants ‐infected mothers with positive e antigen HB eAg) after immunoprophylaxis. We aimed to evaluate the safety and efficacy telbivudine used during late pregnancy for preventing mother‐to‐child transmission . conducted a multicenter prospective cohort study 5 hospitals from 2012 2014, which enrolled singleton pregnant women eAg. By their choice, were divided into therapy (telbivudine 600 mg/day, gestation 28‐32 weeks 3‐4...
Ginseng, the root of Panax ginseng (PG), is used widely as a herbal medicine to prevent and treat various diseases. has pharmacological effects on neurodegenerative diseases such Alzheimer's disease (AD). The present study evaluated neuroprotective PG its possible mechanisms in advanced glycation end product (AGE)-induced AD rat model.Advanced products were injected bilaterally into CA3 region rats' brains. Morris water maze test step-down type passive avoidance performed evaluate their...
Phyllanthus emblica L (PEL), a well-known medical plant, has been used in Asian countries for long time. Increasing evidence suggests that it can prevent the tumorigenesis of cancer associated with nonresolving inflammation. However, possible anti-inflammatory mechanism responsible preventing precancerous lung lesions is not well elucidated.Male A/J mice were randomly divided into 5 groups 10 each group: (1) blank group (saline), (2) benzo(a)pyrene [B(a)P] group, (3) and (4) B(a)P + PEL (5...
Atopic dermatitis (AD) is a common inflammatory skin condition characterized by erythema and pruritus. Its precise pathogenesis remains unclear, though factors such as genetic predisposition, autoantigen response, allergen exposure, infections, barrier dysfunction are involved. Research suggests correlation between AD mitochondrial dysfunction, well oxidative stress in tissues. Skin sample datasets related to (GSE36842, GSE120721, GSE16161, GSE121212) were retrieved from the GEO database....
Abstract Aims/Introduction The present study aimed to determine the associations between expressions of insulin‐like growth factor‐1 ( IGF ‐1), tumor necrosis factor‐α TNF ‐α) and vascular endothelial factor 165 VEGF ) in serum, occurrence development type 2 diabetic nephropathy DN ). Materials Methods A total 108 patients diagnosed as were randomly selected, including 50 microalbuminuria group, 44 macroalbuminuria group 14 renal insufficiency group. Meanwhile, 97 healthy people collected a...
Kainic acid (KA)-induced neuronal death is linked to mitochondrial dysfunction and ER stress. Melatonin known protect hippocampal neurons from KA-induced apoptosis, but the exact mechanisms underlying melatonin protective effects against mitochondria disorder stress remain uncertain. In this study, we investigated sheltering roles of during apoptosis by focusing on mediated signal pathways. KA causes dynamic through calpain activation, leading apoptosis. Ca2+ chelator BAPTA-AM inhibitor...
Background: Cognitive impairment caused by diabetes has been recognized. Berberine is well known for its resistance to peripheral lesions, but it rarely used the treatment of spatial learning and memory diabetes. This study explored mechanism berberine alleviate cognitive via cholinergic anti-inflammatory insulin signaling pathways. Methods: Morris water maze was appraise memory. Positron-emission tomography (PET) imaging adopted detect transport glucose, blood/cerebrospinal fluid (CSF)...
We recently reported that skeletal muscle fibers of obscurin knockout (KO) mice present altered distribution ankyrin B (ankB), disorganization the subsarcolemmal microtubules, and reduced localization dystrophin at costameres. In addition, these have impaired running endurance increased exercise-induced sarcolemmal damage compared with wild-type animals. Here, we report results from a combined approach physiological, morphological, structural studies in which further characterize muscles KO...
Abstract Background The triglyceride glucose-body mass index (TyG-BMI index) has been suggested as a novel predictor of insulin resistance. However, its predictive value for slow coronary flow phenomenon (SCFP) in patients with ischemia and nonobstructive arteries (INOCA) remains unclear. Methods We consecutively recruited 1625 INOCA from February 2019 to 2023 divided them into two groups based on thrombolysis myocardial infarction (TIMI) frame counts (TFCs): the SCFP group ( n = 79) control...
Sepsis-related acute respiratory distress syndrome (ARDS) has a high mortality rate, and no effective treatment is available currently. Quercetin natural plant product with many pharmacological activities, such as antioxidative, anti-apoptotic, anti-inflammatory effects. This study aimed to elucidate the protective mechanism of quercetin against sepsis-related ARDS.
The aim of this study was to investigate the effect hesperidin on liver and kidney dysfunctions induced by nickel. mice were divided into six groups: nickel treatment with 80 mg/kg, 160 320 mg/kg groups, 0.5% CMC-Na group, blank control group. Histopathological techniques, biochemistry, immunohistochemistry, TUNEL method used changes in structure, functions, oxidative injuries, apoptosis kidney. results showed that could alleviate weight loss histological injuries nickel, increase levels...