A5046141625- Advanced biosensing and bioanalysis techniques
- Catalytic C–H Functionalization Methods
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Medicinal Plants and Neuroprotection
- Multiple Myeloma Research and Treatments
- Quantum Dots Synthesis And Properties
- Traditional Chinese Medicine Analysis
- RNA Interference and Gene Delivery
- Synthesis and Catalytic Reactions
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Studies
- Acute Myeloid Leukemia Research
- Natural product bioactivities and synthesis
- Medicinal Plant Research
- Retinoids in leukemia and cellular processes
- Pharmacological Effects of Natural Compounds
- Cancer Treatment and Pharmacology
- Catalytic Alkyne Reactions
- Asymmetric Synthesis and Catalysis
- Advanced Biosensing Techniques and Applications
- Synthesis and biological activity
- Crystal structures of chemical compounds
- Cell death mechanisms and regulation
- Heavy Metals in Plants
Changzhou University
2010-2024
Shandong University of Traditional Chinese Medicine
2018-2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2019-2024
Anhui Normal University
2019-2024
Shandong Police College
2021
Jiangsu Provincial Academy of Traditional Chinese Medicine
2012-2015
Nanjing University of Chinese Medicine
2012-2014
Jiangsu University of Technology
2010
Abstract: In this study, a novel carbon nanopowder (CNP) drug carrier was developed to improve the oral bioavailability of apigenin (AP). Solid dispersions (SDs) AP with CNP were prepared, and their in vitro release vivo performance evaluated. The physicochemical properties formulations examined by differential scanning calorimetry, X-ray diffraction, electron microscopy. Drug profiles showed that dissolution from CNP-AP system (weight ratio, 6:1) after 60 minutes improved 275% compared pure...
Human multiple myeloma (MM) is a malignant and incurable B cell tumor. Zinc oxide nanoparticles (ZnO NPs) have been widely used in biomedical fields including anti-bacterial anti-tumor. However, the influence of ZnO NPs on MM cells still unclear. The present study aimed to investigate effect (a human myeloma-derived RPMI8226 line) death vitro underlying mechanism. morphology was characterized by transmission electron microscopy (TEM), inhibitory apoptotic monitored CCK-8 method an Annexin...
Efficient access to multiple functionalized allenes via a three component 1,4-alkylcyanation of enynes with cyclic alcohol derivatives in the presence trimethylsilyl cyanide (TMSCN) under copper/photoredox dual catalysis has been developed. Both easily transformable aldehyde and cyano groups were introduced tetra-substituted through light-induced C–C bond cleavage butanol pentanol derivatives. The reactions proceeded smoothly mild conditions broad functional tolerance.
Efficient access to cyclic imine-containing indoline derivatives through palladium-catalysed dearomative aryl/cycloimidoylation of indoles using functionalized isocyanides has been developed.
Zinc oxide nanoparticles (ZnO NPs) have exhibited excellent anti-tumor properties; the present study aimed to elucidate underlying mechanism of ZnO NPs induced apoptosis in acute myeloid leukemia (AML) cells by regulating mitochondrial division. THP-1 cells, an AML cell line, were first incubated with different concentrations for 24 hr. Next, expression Drp-1, Bcl-2, Bax mRNA, and protein was detected, effects on levels reactive oxygen species (ROS), membrane potential (Δψm), apoptosis, ATP...
Abstract In the present contribution, ultrafine fiber membranes of polyhydroxybutyrate (PHB) and organic‐soluble chitosan(O‐CS) was prepared by electrospinning. The structure thermal stability were studied infrared (FTIR) thermogravimetric analysis (TG). surface properties fibers estimated contact angle measurements using water. morphology observed scanning electron microscopy (SEM). cytotoxicity assessment with mouse fibroblast cells (L929) also investigated. Cell culture results showed...
A palladium-catalysed construction of spiroindolines through dearomative spirocyclization 3-(2-isocyanoethyl)indoles has been developed. 2'-Aryl-, vinyl-, and alkyl-substituted could be accessed under mild conditions with excellent functional group tolerance. C1-tethered oxindole- indole-spiroindoline bisheterocycles were generated in high yields via alkene/allene insertion an imidoylative cascade. Additionally, a tandem dearomatization two different indoles was realized...
A novel strategy to access unsymmetrically linked heterocycles via palladium-catalyzed acylcycloimidoylation of alkyne-tethered carbamoyl chlorides with isocyanides has been developed. Functionalized were successfully applied as imine-containing heterocycle precursors capture the vinyl-PdII intermediate, which was generated from a syn-carbopalladation alkyne, followed by subsequent intramolecular C-H bond activation/imidoylative Heck reactions. Methylene oxindoles within Z-tetrasubstituted...
An intermolecular enantioselective synthesis of 1H-isoindoles containing tri- and difluoromethylated quaternary stereogenic centers through a palladium-catalyzed desymmetric C–H bond imidoylation has been developed. α,α-Diaryl difluoroethylated isocyanides acted as powerful precursors chiral 1H-isoindoles, in which the fluoroalkyl group was proven to play crucial role both stereochemistry reaction efficiency. In addition, an allene insertion cascade realized, offering rapid access diverse...
As is well known, quantum dots (QDs) have become valuable probes for cancer imaging. In particular, QD-labeled targeting peptides are capable of identifying or tumors cells. A new colorectal peptide, cyclo(1, 9)-CTPSPFSHC, has strong ability and also shows great potential in the identification treatment colon cancer. Herein, we synthesized a dual functional polypeptide, 9)-CTPSPFSHCD2 G2 DP9 G3 H6 (H6 -TCP), to investigate its interaction with QDs inside capillary. Fluorescence-coupled CE...
Polyhistidine peptides are effective ligands to coat quantum dots (QDs). It is known that both the number of histidine (His) residues repeats and their structural arrangements in a peptide ligand play important roles assembly onto CdSe/ZnS QDs. However, due steric hindrance, sequence with more than six His residue tandem would hardly coordinate well Zn(2+) QD shell further enhance binding affinity. To solve this problem, His-containing ligand, ATTO 590-E2 G (NH)6 (ATTO-NH), was specifically...
Wedelolactone (WED) is commonly used for the treatment of doxorubicin (DOX) - induced kidney damage, but its efficacy limited by poor solubility and bioavailability. In this study, we developed a novel delivery system WED-loaded micelles (WED-M) with Solutol® HS15 lecithin at an optimized ratio 7:3 to improve permeability bioavailability WED enhance efficacy. The spherical-shaped WED-M (particle size : 160.5±3.4 nm; zeta potential -30.1±0.9 mV; entrapment efficiency: 94.41±1.64%; drug...
An intermolecular controllable Pd-catalyzed spirocyclization of isocyano cycloalkenes has been developed, offering efficient and selective approaches toward spirocyclic hydropyrrole scaffolds. 2-Azaspiro-1,7-dienes could be obtained through a "chain-walking" process with aryl/vinyl iodides as electrophiles, while the normal Heck product 2-azaspiro-1,6-dienes were selectively generated when aryl triflates used coupling partner isocyanides. Mechanistic studies suggested that counteranion...
Suet oil (SO) has been used commonly for food and medicine preparation. The determination of its elemental composition became an important challenge human safety health owing to possible contents heavy metals or other elements. In this study, ultrawave single reaction chamber microwave digestion (Ultrawave) inductively coupled plasma-mass spectrometry (ICP-MS) analysis was performed determine 14 elements (Pb, As, Hg, Cd, Fe, Cu, Mn, Ti, Ni, V, Sr, Na, Ka Ca) in SO samples. Furthermore, the...
The dynamic binding status between the thrombin and its G‐quadruplex aptamers stability of interaction partners were probed using our previously established fluorescence‐coupled capillary electrophoresis method. A 29‐nucleic acid aptamer was chosen as a model to study affinity with ligand. First, effects cations on formation from unstructured examined. Second, rapid kinetics 6‐carboxyfluorescein labeled measured. Third, aptamer–thrombin complex also examined in presence interfering species....
The first example of silver-promoted [3+4] cycloaddition α-isocyanoacetates with anthranils as aromatic Michael accepters, offering access to benzo[d][1,3]diazepinones, has been developed. Mechanistic studies revealed that an "oxygen migration" rearrangement process was involved in this dearomative reaction. Additionally, benzo[d][1,3]diazepinones were obtained efficiently well under catalytic conditions. Broad functional groups tolerated mild reaction