A5091562588- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Multicomponent Synthesis of Heterocycles
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Catalytic Alkyne Reactions
- Catalytic Cross-Coupling Reactions
- Synthesis of Indole Derivatives
- Click Chemistry and Applications
- Synthetic Organic Chemistry Methods
- Crystallography and molecular interactions
- Synthesis and Biological Evaluation
- Oxidative Organic Chemistry Reactions
- Synthesis of Organic Compounds
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Characterization of Pyrroles
- Synthesis and Reactivity of Heterocycles
- Synthesis and biological activity
- Molecular spectroscopy and chirality
- Fluorine in Organic Chemistry
Anhui Normal University
2016-2025
Hainan Medical University
2025
Peking University
2025
Wuhan University
2019-2023
Wuhu Institute of Technology
2019-2021
Ministry of Education of the People's Republic of China
2011-2021
Zhengzhou University of Light Industry
2020
East China Normal University
2016
Anhui University
2015
Liaoning Technical University
2013
Iron excess is closely associated with tumorigenesis in multiple types of human cancers, underlying mechanisms yet unclear. Recently, iron deprivation has emerged as a major strategy for chemotherapy, but it exerts tumor suppression only on select malignancies. Here, we report that the suppressor protein p53 downregulated during excess. Strikingly, polyporphyrin heme binds to protein, interferes p53-DNA interactions, and triggers both nuclear export cytosolic degradation p53. Moreover,...
A mild photoredox catalyzed construction of sulfides, disulfides, selenides, sulfoxides and sulfones from unstrained ketone precursors is introduced. Combination this deacylative process with S
We report a dual-tasked methylation that is based on cooperative palladium/norbornene catalysis. Readily available (hetero)aryl halides (39 iodides and 4 bromides) inexpensive MeOTs or trimethylphosphate are utilized as the substrates methylating reagent, respectively. Six types of "ipso" terminations can modularly couple with this "ortho" C–H to constitute versatile toolbox for preparing diversified methylated arenes. This features methyl sources, excellent functional-group tolerance,...
Deconstructive alkynylation of an unstrained ketone catalyzed by organic photocatalyst under blue light irradiation is reported for the first time. A broad substrate scope with up to 63 examples, excellent functional group tolerance, and gram scale reaction demonstrated practicality this novel method. The dihydroquinazolinone derivative trifluoroacetophenone had been proved have potential as a trifluoromethylation reagent after working well various alkynyl bromides.
Solvothermal reactions of tetrakis(4-pyridyloxymethylene)methane (TPOM) with deprotonated 1,4-benzenedicarboxylate (H2bdc) or 5-hydroxyisophthalic acid (5-OH-H2bdc) in the presence nitrates cadmium, zinc, and cobalt H2O H2O/DMF produced five new complexes, namely, {[Cd2(TPOM)(bdc)2]·(H2O)5(DMF)}n (1), {[Zn2(TPOM)(bdc)2]·(H2O)4}n (2), {[Zn2(TPOM)(bdc)2]·(H2O)}n (3), {[Co2(TPOM)(5-OH-bdc)2(H2O)2]·(H2O)5}n (4), {[Cd2(TPOM)(5-OH-bdc)2]·(H2O)2}n (5). These complexes were characterized by...
The concise collective total synthesis of englerin A and B, orientalol E F, oxyphyllol has been accomplished in 10-15 steps, with the being achieved for first time. success obtained was enabled by realization [4+3] cycloaddition reaction 9 10. Other features include 1) intramolecular Heck to access azulene core, 2) epoxidation-S(N)2' reduction sequence allylic alcohol, 3) efficient regioselective stereoselective formal hydration bridging C=C bond englerins, 4) late-stage chemo- C-H oxidation...
A mild and efficient Rh(III)-catalyzed C-H activation/esterification reaction for the synthesis of isocoumarins has been developed. This procedure uses readily available benzoic acids cyclic diazo-1,3-diketones as starting materials involves domino intermolecular activation in combination with intramolecular esterification to give corresponding moderate excellent yields. process provides a facile approach construction containing various functional groups that does not require any additives.
A highly enantioselective 1,3-dipolar cycloaddition of imino esters with methyleneindolinones has been realized by using readily available thiourea–quaternary ammonium salts as phase-transfer catalysts, enabling efficient construction a range chiral spiro[pyrrolidin-3,3′-oxindoles] in good yields excellent enantioselectivities under mild conditions.
Efficient access to multiple functionalized allenes via a three component 1,4-alkylcyanation of enynes with cyclic alcohol derivatives in the presence trimethylsilyl cyanide (TMSCN) under copper/photoredox dual catalysis has been developed. Both easily transformable aldehyde and cyano groups were introduced tetra-substituted through light-induced C–C bond cleavage butanol pentanol derivatives. The reactions proceeded smoothly mild conditions broad functional tolerance.
An elegant and highly concise strategy for the construction of coumarin-functionalized pyrrolo[2,1-a]isoquinolines from available propargylamines isoquinolinium N-ylides has been disclosed. In this reaction, acted as a C2 synthon to form coumarin ring well 1,3-dipole construct pyrrole in single pot. This cascade process involves 1,4-conjugate addition/lactonization/1,3-dipolar cycloaddition four chemical bonds (one C–O bond three C–C bonds) two new heterocyclic skeletons. Additionally, most...
Solvothermal reactions of 4,4′-bis(imidazol-1-yl)diphenyl ether (BIDPE) with deprotonated 1,4-benzenedicarboxylic acid (H2bdc) in the presence cadmium, zinc, cobalt, nickel, and manganese salts H2O or H2O/DMF yielded six new complexes, namely, {[Co(BIDPE)(bdc)]2·(H2O)2(DMF)}n (1), {[Cd(BIDPE)(bdc)]4·(H2O)4(DMF)2}n (2), {[Zn(BIDPE)(bdc)]2·(H2O)2(DMF)}n (3), [Cd3(BIDPE)2(bdc)3]n (4), [Ni(BIDPE)(bdc)(H2O)2]n (5), [Mn(bdc)(BIDPE)(H2O)]n (6). These complexes were characterized by elemental...
We report an efficient route to pyridine derivatives via FeCl3-catalyzed four-component nucleophilic addition/intermolecular cyclization. This simple fragment assembly strategy uses mild conditions and affords a broad range of polysubstituted pyridines in moderate good yield from readily available starting materials. A plausible mechanism for this process is proposed.
The enantioselective construction of five-membered spirocyclic oxindoles via a double Michael cascade reaction is described by using dipeptide-based multifunctional quaternary phosphonium salt catalysts. desired products were obtained in excellent yields (up to 94%) and good high stereoselectivities >19:1 dr 99% ee).
A simple C–H/N–H bond functionalization of N-aryl amidines with cyclic 2-diazo-1,3-diketones for the synthesis 1-aminoisoquinolines has been accomplished by employing [Cp*RhCl2]2/CsOPiv as catalyst system. This methodology proceeds a cascade C–H activation/intramolecular cyclization under mild reaction conditions, features broad substrate scope, and involves formation two new σ bonds (C–C C–N) in single operation construction novel 1-aminoisoquinoline skeletons good to excellent yields.
Abstract Steroidal C19-hydroxylation is pivotal to the synthesis of naturally occurring bioactive C19-OH steroids and 19-norsteroidal pharmaceuticals. However, realizing this transformation proved be challenging through either chemical or biological synthesis. Herein, we report a highly efficient method synthesize 19-OH-cortexolone in 80% efficiency at multi-gram scale. The obtained C 19 -OH-cortexolone can readily transformed various synthetically useful intermediates including industrially...
Efficient access to cyclic imine-containing indoline derivatives through palladium-catalysed dearomative aryl/cycloimidoylation of indoles using functionalized isocyanides has been developed.
Abstract Heterocycles 2-pyridone and uracil are privileged pharmacophores. Diversity-oriented synthesis of their derivatives is in urgent need medicinal chemistry. Herein, we report a palladium/norbornene cooperative catalysis enabled dual-functionalization iodinated 2-pyridones uracils. The success this research depends on the use two unique norbornene as mediator. Readily available alkyl halides/tosylates aryl bromides utilized ortho -alkylating -arylating reagents, respectively. Widely...
A DBU-catalyzed one-pot cascade reaction of propargylamines and water for the synthesis flavanones has been developed. This process proceeds via a sequence 1,4-conjugate addition to alkynyl o-quinone methide (o-AQM), followed by alkyne–allene isomerization subsequent intramolecular oxa-Michael addition. strategy provides convenient method accessing broad range in good excellent yields with functional-group tolerance, particular, reactive halo functional groups.
With a tandem DMAP-catalyzed reaction between o-AQM, in which it is generated situ from propargylic amine, and acyl carbene surrogate (from pyridinium ylide), variety of polyarylated chromenes are assembled good yields. This process does not require transition-metal catalyst exhibits easy manipulation the arene group functional compatibility, particularly −Br can be further transformed to other functionalities by cross-coupling reactions. The modular feature o-AQM substrates simple operation...
Efficient access to fluoroalkyl indoles and isoquinolones through palladium-catalysed aryl/monofluoroalkylation of allenamides has been developed.
An efficient Rh(III)-catalyzed C-H activation of azobenzenes and subsequent [4+1] cascade annulation with CF3-imidoyl sulfoxonium ylides was developed, yielding diverse CF3-indazoles. This protocol featured easily available starting materials, excellent functional group tolerance high efficiency. Moreover, the antitumor activities selected CF3-indazoles against human cancer cell lines were also studied, results indicated that several compounds displayed considerable antiproliferative activities.
An organocatalytic approach for the construction of 2,3-dihydrobenzofuran scaffold through a formal [4 + 1] annulation 2-(2-nitrovinyl)phenols and α-bromoacetophenones in presence 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed. This protocol could be easily performed one mmol scale, giving broad range derivatives moderate to excellent yields remarkable diastereoselectivity (>20 : 1 dr general) with good functional group tolerance.