A5011725342- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- RNA modifications and cancer
- Circular RNAs in diseases
- Multicomponent Synthesis of Heterocycles
- Asymmetric Synthesis and Catalysis
- Cancer Immunotherapy and Biomarkers
- Protein Degradation and Inhibitors
- Catalytic C–H Functionalization Methods
- Chemical synthesis and alkaloids
- Synthesis and pharmacology of benzodiazepine derivatives
- Synthesis and Characterization of Pyrroles
- Phagocytosis and Immune Regulation
- Cancer Mechanisms and Therapy
First Affiliated Hospital of Wannan Medical College
2023-2025
Wannan Medical College
2023-2025
Anhui Normal University
2024
Viva Biotech (China)
2022
An elegant and highly concise strategy for the construction of coumarin-functionalized pyrrolo[2,1-a]isoquinolines from available propargylamines isoquinolinium N-ylides has been disclosed. In this reaction, acted as a C2 synthon to form coumarin ring well 1,3-dipole construct pyrrole in single pot. This cascade process involves 1,4-conjugate addition/lactonization/1,3-dipolar cycloaddition four chemical bonds (one C–O bond three C–C bonds) two new heterocyclic skeletons. Additionally, most...
Gliomas, particularly glioblastomas (GBM), are highly aggressive with a poor prognosis and low survival rate. Currently, deoxyelephantopin (DET) has shown promising anti-inflammatory anti-tumor effects. Using clinical prognostic analysis, molecular docking, network pharmacology, this study aims to explore the primary targets signaling pathways identify novel GBM treatment approaches. PharmMapper, chemical structure of DET was examined for possible after being acquired from PubChem....
Abstract A concise and practical sustainable strategy for modular access to isoquinoline‐fused benzo[ f ][1,3]oxazepine derivatives through a formal [4+3] annulation of commercially available salicyaldehydes with isoquinolinium salts has been developed. The reactions proceeded the formation two new bonds (C=C C−O) seven‐membered heterocyclic ring in one pot. Remarkably, use simple NaHCO 3 as mild base, open atmosphere, nonhazardous reagents, nice functional group tolerance, easily scale up...
Abstract Adoptive cell therapy (ACT) with expanded Tumor-infiltrating lymphocytes (TIL) or TCR gene-modified T cells (TCR-T) that recognize mutant KRAS neo-antigens can mediate tumor regression in patients advanced pancreatic ductal adenocarcinoma (PDAC) (1 2) . The targeted ACT holds great potential to achieve durable clinical responses for PDAC, which has had no meaningful improvement over 40 years. However, the wide application of KRAS-centric is currently limited by rarity TIL KRAS. In...