A5025089090- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- GaN-based semiconductor devices and materials
- Silicon Carbide Semiconductor Technologies
- Semiconductor materials and devices
- Genetic factors in colorectal cancer
- Pancreatitis Pathology and Treatment
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- CAR-T cell therapy research
- Genomics and Phylogenetic Studies
- Ga2O3 and related materials
- Cancer Immunotherapy and Biomarkers
- Gallbladder and Bile Duct Disorders
- Glioma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Urinary and Genital Oncology Studies
- Evolution and Genetic Dynamics
- Plasma Diagnostics and Applications
- Appendicitis Diagnosis and Management
- Hepatitis B Virus Studies
- BRCA gene mutations in cancer
- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
Annoroad Gene Technology (China)
2020-2024
Yale University
2019-2023
Nanjing Medical University
2022-2023
Nanjing University
2000-2022
Nanjing General Hospital of Nanjing Military Command
2012-2022
Civil Aviation Flight University of China
2022
Fujian University of Traditional Chinese Medicine
2021-2022
Jinling Institute of Technology
2019-2021
Committee on Publication Ethics
2021
Heilongjiang Postdoctoral Fund
2021
Liquid biopsies, based on cell free DNA (cfDNA) and proteins, have shown the potential to detect early stage cancers of diverse tissue types. However, most these studies were retrospective, using individuals previously diagnosed with cancer as cases healthy controls. Here, we developed a liquid biopsy assay, named hepatocellular carcinoma screen (HCCscreen), identify HCC from surface antigen hepatitis B virus (HBsAg) positive asymptomatic in community population. The training cohort...
The majority of glioblastomas can be classified into molecular subgroups based on mutations in the TERT promoter (TERTp) and isocitrate dehydrogenase 1 or 2 (IDH). These utilize distinct genetic mechanisms telomere maintenance, either TERTp mutation leading to telomerase activation ATRX-mutation an alternative lengthening telomeres phenotype (ALT). However, about 20% lack alterations IDH. tumors, designated TERTpWT-IDHWT glioblastomas, do not have well-established biomarkers defined...
Brainstem gliomas are a heterogeneous group of tumors that encompass both benign cured with surgical resection and highly lethal cancers no efficacious therapies. We perform comprehensive study incorporating epigenetic genomic analyses on large cohort brainstem gliomas, including Diffuse Intrinsic Pontine Gliomas. Here we report, from DNA methylation data, distinct clusters termed H3-Pons, H3-Medulla, IDH, PA-like, each associated unique clinical profiles. The majority within H3-Pons...
Abstract To avoid the complex core surface functionalization or pretreatment that is necessary in order to coat latex and silica colloids with a uniform, complete metal shell, solvent‐assisted route has been explored prepare (Ag Au) shell controlled thickness on polystyrene (PS) electroless plating approach, based electrostatic attraction, silver colloids. Without any additional treatment, as‐prepared core–shell can be crystallized directly into long‐range‐ordered structures photonic...
Abstract Background Undifferentiated carcinoma with osteoclast-like giant cells (OGCs) of pancreas (UCOGCP) is a rare subtype pancreatic ductal adenocarcinoma (PDAC), which had poorly described histopathological and clinical features. Methods In this study, single-cell RNA sequencing (scRNA-seq) was used to profile the distinct tumor microenvironment UCOGCP using samples obtained from one patient three PDAC patients. Bioinformatic analysis carried out immunohistochemical (IHC) staining...
Abstract Background Early detection of colorectal cancer (CRC) significantly enhances patient outcomes. Conventional CRC screening tools, like endoscopy and stool-based tests, have constraints due to their invasiveness or suboptimal adherence. Recently, liquid biopsy employing plasma cell-free DNA (cfDNA) has emerged as a potential noninvasive technique for various malignancies. Methods In this research, we harnessed the Mutation Capsule Plus (MCP) technology profile an array genomic...
Abstract Fusion of RET with different partner genes has been detected in papillary thyroid, lung, colorectal, pancreatic, and breast cancer. Approval selpercatinib for treatment lung thyroid cancer gene mutations or fusions calls studies to explore fusion partners their eligibility RET‐based targeted therapy. In this study, patterns a large group Chinese patients covering several types were identified using next‑generation sequencing. A total 44 the study cohort KIF5B , CCDC6 ERC1 being most...
Fluid therapy may be one of the most controversial topics in perioperative management. However, data concerning influence fluid administration on complications after pancreaticoduodenectomy are sparse.A group 147 patients underwent for benign or malignant pathology pancreas periampullary region between 2005 and 2009. Clinical data, overall morbidity, long-term outcomes were recorded.We categorized into two groups according to intraoperative volume administration: a low (LFVG, <8.2 ml kg(-1)...
Abstract Selective area doping in GaN, especially p-type, is a critical and inevitable building block for the realization of advanced device structures high-power applications, including, but not limited to, current-aperture vertical electron transistors, junction termination extensions, barrier Schottky diodes, field-effect transistors (JFETs), vertical-channel JFETs, U-shaped metal–oxide–semiconductor (U-MOSFETs), Fin MOSFETs. This paper reviews summarizes some recent advances fields...
To take full advantages of Wide Bandgap power semiconductor devices, breakthroughs on module development are heavily explored nowadays. This paper introduces a 1.2kV SiC half bridge intelligent utilizing 80μm flexible epoxy-resin as substrates instead traditional Direct-bonded Copper, for better thermal-stress management and lower cost. The investigation the material indicates that it has low leakage current even at 250 °C, high thermal conductivity up to 8 W/mK. No bonding wires applied in...
In the Letter, we demonstrate an improved electroless plating method for synthesis of bimetallic shell particles. The procedure involves a combination surface reaction, seeding growth, and removal supporting cores. We modified ammonical AgNO3 in ethanol with controlled amount HCHO process uniform relatively dense coverage silver nanoparticle seeds on colloid cores was achieved. Following second kind metal plating, extended this to prepare continuous core-shell hollow particles submicrometer...
Conventional clinical detection methods such as CT, urine cytology, and ureteroscopy display low sensitivity and/or are invasive in the diagnosis of upper tract urinary carcinoma (UTUC), a factor precluding their use. Previous studies on biopsy have not shown satisfactory specificity application both gene mutation or methylation panels. Therefore, these unfavorable factors call for an urgent need sensitive non-invasive method UTUC.In this study, total 161 hematuria patients were enrolled...
As one of the most aggressive human tumors, pancreatic cancer (PC) is accompanied by poor treatment and prognosis. Although emerging evidence has highlighted importance long noncoding RNAs in multiple cancers, specific regulatory roles mostly remain obscure. Our aim was to disclose role CERS6 antisense RNA 1 (CERS6-AS1) PC.Quantitative real-time polymerase chain reaction analysis used examine expression CERS6-AS1 PC cell lines. Western blot assess protein levels high-mobility group AT-hook...
PD-1/PD-L1 blocking therapy has become one of the most promising methods in field tumor treatment. However, it encounters challenge immune escape due to exhaustion T cells. Studies have shown that epigenetic regulation drug histone deacetylase inhibitor (HDACi) may be able reverse exhausted cells by changing transcription program. Therefore, combination and blockade is expected escape, whereas overriding goal should aim at spontaneous release synergy siRNA HDACi. In this study, we develop...
Purpose Universal germline testing in patients with colorectal cancer (CRC) a multigene panel can detect various hereditary syndromes. This study was performed to understand how choose and whether the result would affect clinical management. Methods We prospectively enrolled 486 eligible CRC, including all CRC diagnosed under age 70 years over risk features between November 2017 January 2018. All participants received for Results The prevalence of pathogenic variants (PVs) susceptibility...
Combination immunotherapy can overcome the limited objective response rates of PD-1 blockade. Interferon alpha (IFN-α) has been proven to be effective in modulating immune responses and may enhance clinical According practice guidelines, IFN-α was recommended as adjuvant therapy for stage IIB/C melanoma patients. However, impact prior on efficacy subsequent blockade not previously reported. Therefore, we performed a retrospective analysis patients addressed whether enhanced pembrolizumab...
Nonplanar GaN p–n junctions formed by selective area regrowth were analyzed using pulsed laser atom probe tomography. Dilute Al marker layers used to map the evolution of p-GaN growth interface, enabling extraction time-varying rates for nonpolar, semipolar, and polar surfaces from trench edge center, respectively. The Mg dopant concentration is facet-dependent varies inversely with rate semipolar facets that grow rapidly away sidewalls. negligible on vertical sidewall coincides an order...
Abstract Optical engineering of gallium nitride (GaN) semiconductor material has enabled novel applications and technologies. 3D optical is challenging mostly accomplished by surface‐level patterning with subtractive or additive means. In this work a pathway, based on epitaxial conductivity control in conjunction ion implant subsequent electrochemical etching, to generate complex embedded nanoporous (NP)‐GaN/GaN air/GaN structures presented. A range subsurface demonstrated including in‐plane...
Solid pseudopapillary neoplasm (SPN) of the pancreas shows an indolent clinical behavior in cases undergoing surgical resection. The efficacy combination therapy metastatic extrapancreatic SPN treatment remains largely unknown and a challenge.We report case pancreatic 45-year-old woman who presented with aggressive peritoneal dissemination hepatic metastases still showed course repeated surgery targeted therapy. Although follow-up effect to be seen, this is first practical experience agents...