A5075776410- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- DNA Repair Mechanisms
- Meningioma and schwannoma management
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Chromatin Remodeling and Cancer
- PARP inhibition in cancer therapy
- Adrenal and Paraganglionic Tumors
- Telomeres, Telomerase, and Senescence
- Neuroblastoma Research and Treatments
- RNA Interference and Gene Delivery
- Animal Virus Infections Studies
- Ferroptosis and cancer prognosis
- interferon and immune responses
- Advanced MRI Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Cell death mechanisms and regulation
- Extracellular vesicles in disease
- Neurogenesis and neuroplasticity mechanisms
Huazhong University of Science and Technology
2017-2025
Beijing Tian Tan Hospital
2016-2024
Capital Medical University
2016-2024
Beijing University of Chinese Medicine
2024
Duke University Hospital
2020-2023
Duke Medical Center
2020-2023
Wenzhou Medical University
2022-2023
Renmin Hospital of Wuhan University
2023
Wuhan University
2023
Tongji Hospital
2018-2022
BackgroundUltrasound is a critical non-invasive test for preoperative diagnosis of ovarian cancer. Deep learning making advances in image-recognition tasks; therefore, we aimed to develop deep convolutional neural network (DCNN) model that automates evaluation ultrasound images and facilitate more accurate cancer than existing methods.MethodsIn this retrospective, multicentre, diagnostic study, collected pelvic from ten hospitals across China between September 2003, May 2019. We included...
Brainstem gliomas are a heterogeneous group of tumors that encompass both benign cured with surgical resection and highly lethal cancers no efficacious therapies. We perform comprehensive study incorporating epigenetic genomic analyses on large cohort brainstem gliomas, including Diffuse Intrinsic Pontine Gliomas. Here we report, from DNA methylation data, distinct clusters termed H3-Pons, H3-Medulla, IDH, PA-like, each associated unique clinical profiles. The majority within H3-Pons...
Diffuse intrinsic pontine glioma (DIPG) is a rare and fatal pediatric brain tumor. Mutation of p53-induced protein phosphatase 1 (PPM1D) in DIPG cells promotes tumor cell proliferation, inhibition PPM1D expression with mutation effectively reduces the proliferation activity cells. Panobinostat kills cells, but its systemic toxicity low blood-brain barrier (BBB) permeability limits application. In this paper, nano drug delivery system based on functionalized macrophage exosomes panobinostat...
Abstract Background Polychlorinated biphenyls (PCBs) were associated with cardiovascular disease (CVD) in the general population. However, it is unclear whether PCBs exposure increases additional risk of CVD among type 2 diabetes (T2D) cases. This study aims to investigate associations between serum concentrations and incident T2D Methods The population was derived from Dongfeng-Tongji cohort 2008 followed up until December 31, 2018, a total 2,806 participants included 1180 them developed...
Abstract Background Telomere maintenance mechanisms are required to enable the replicative immortality of malignant cells. While most cancers activate enzyme telomerase, a subset uses telomerase-independent termed alternative lengthening telomeres (ALT). ALT occurs via homology-directed-repair and is frequently associated with ATRX mutations. We previously showed that adult glioblastoma (GBM) patients ATRX-expressing ALT-positive tumors harbored loss-of-function mutations in SMARCAL1 gene,...
Small RNAs (sRNAs) are important non-coding RNA regulators, playing key roles in developmental regulation, transposon suppression, environmental response, host-pathogen interaction and other diverse biological processes. However, their oomycetes poorly understood. Here, we performed sRNA sequencing of P. parasitica at stages vegetative growth infection Arabidopsis roots to examine diversity function sRNAs parasitica, a model hemibiotrophic oomycete plant pathogen. Our results indicate that...
// Cheng Xu 1, * , Xiaoqing Liu 2, 4, Yibo Geng 1 Qingran Bai 4 Changcun Pan Yu Sun Xin Chen Hai Yuliang Wu Peng Zhang Wenhao Wang Zhen Junting Zhaohui 3 Rui Yang Jenna Lewis Darell Bigner Fangping Zhao 5 Yiping He Yan Qin Shen 2 and Liwei Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Center for Life Sciences, Stem Cell Biology Regenerative Medicine, School Tsinghua Pathology, Duke University Center, The Preston Robert Tisch Brain Tumor...
We aimed to detect the role of LINC00472 via regulating miR-24-3p and death effector domain-containing DNA-binding protein in lung adenocarcinoma.Long noncoding RNA, microRNA, messenger RNA levels were determined using reverse transcription quantitative polymerase chain reaction. The expression was Western blot assay. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay colony formation conducted explore proliferation cells. cell apoptosis tested by flow cytometry Target...
BackgroundDiffuse intrinsic pontine glioma (DIPG) is a rare and fatal pediatric brain cancer without cure. Seeking therapeutic strategies still major challenge in DIPG research. Previous study has shown that dysregulation of G1/S cell cycle checkpoint was common this even more enriched the H3.3K27 M mutant subgroup. Here we assess potential anti-tumor efficacy palbociclib, specific cytostatic inhibitor CDK4/6, on high grade H3.3-K27 M-mutant DIPGs vitro vivo.MethodsWe established...
Previous resting-state functional magnetic resonance imaging (fMRI) studies have shown neural connectivity alterations after the treatment of tinnitus. We aim to study value baseline features network nodes predict outcomes sound therapy through adjusted narrow band noise. The fMRI data 27 untreated tinnitus patients and matched healthy controls were analyzed. calculated graph-theoretical metric degree centrality (DC) characterize nodes. Therapeutic are determined by changes in Tinnitus...
Diffuse intrinsic pontine glioma (DIPG) is an invariably fatal brain tumor occurring predominantly in children. Up to 90% of pediatric DIPGs harbor a somatic heterozygous mutation resulting the replacement lysine 27 with methionine (K27M) genes encoding histone H3.3 (H3F3A, 65%) or H3.1 (HIST1H3B, 25%). Several studies have also identified recurrent truncating mutations gene protein phosphatase 1D, PPM1D, 9%-23% DIPGs. Here, we sought investigate therapeutic potential targeting alone...
We investigated the prognostic significance of nidogen-1 (NID1) in glioma. Oncomine, GEPIA, UALCAN, CCGA database analyses showed that NID1 transcript levels were significantly upregulated multiple cancer types, including gliomas. Quantitative RT-PCR confirmed expression was glioma tissues compared to paired adjacent normal brain tissue samples (n=9). silencing enhanced vitro apoptosis and temozolomide sensitivity U251 U87-MG cells. Protein-protein interaction network analysis using STRING...
Cullin7 is an E3 ubiquitin ligase. The protein family functions as a molecular scaffold to coordinate substrate ubiquitination in Skp, Cullin, and F-box-containing complex (SCF complex). Cullin7s control normal development primary cellular processes are characterized by unique genomic network organization. Less known about the involvement of with hepatocellular carcinoma (HCC). In this study, we found that showed high expression HCC tumor tissues, especially metastatic tissues. Also, there...
Quiescin sulfhydryl oxidase 1 (QSOX1) involves in the formation of disulfide bonds and participates protein folding process. In recent years, accumulating evidences have shown that QSOX1 is a biomarker for tumor development prognosis. However, biological function glioblastoma (GBM) remains unclear.QSOX1 expression glioma overall survival patients were analyzed through The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) databases. shRNAs used to decrease U87 U251 cells. Celltiter-Glo colony...
Abstract PARP inhibitors (PARPi) are efficacious in treating high-grade serous ovarian cancer (HG-SOC) with homologous recombination (HR) deficiency. However, they exhibit suboptimal efficiency HR-proficient cancers. Here, we found that the expression of CCAAT/enhancer-binding protein β (C/EBPβ), a transcription factor, was inversely correlated PARPi sensitivity vitro and vivo, both condition. High C/EBPβ enhanced tolerance; treatment turn induced expression. directly targeted upregulated...
The three isoforms of 3R-tau are predominantly deposited in neurons bearing neurofibrillary tangles Alzheimer’s disease (AD), while only accumulation has been detected Pick’s (PiD), suggesting the involvement neurodegeneration. However, both role and molecular mechanism neurodegeneration elusive. Here, we co-expressed human wild-type adult mouse hippocampal to mimic pathologic tau accumulating observed PiD patients. We found that co-expressing induced hyperphosphorylation proteins;...
Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumour. However, causes of GBM are not clear, prognosis remains poor. The aim present study was to elucidate key coding genes long non‑coding RNAs (lncRNAs) associated with survival time patients by obtaining RNA expression profiles from Chinese Glioma Genome Atlas database conducting weighted gene co‑expression network analysis. Modules overall (OS) were identified, Gene Ontology pathway enrichment...