A5100724109- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- COVID-19 Clinical Research Studies
- Cytokine Signaling Pathways and Interactions
- Extracellular vesicles in disease
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- Diet, Metabolism, and Disease
- SARS-CoV-2 and COVID-19 Research
- PARP inhibition in cancer therapy
- Advanced Glycation End Products research
- MicroRNA in disease regulation
- Ovarian cancer diagnosis and treatment
- Liver Disease Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Cancer Cells and Metastasis
- CRISPR and Genetic Engineering
- Mesenchymal stem cell research
- Cancer, Stress, Anesthesia, and Immune Response
Peking University People's Hospital
2025
Peking University
2025
Sichuan University
2025
State Key Laboratory of Biotherapy
2025
Hebei Medical University
2013-2024
Second Hospital of Hebei Medical University
2013-2024
Fujian Medical University
2023-2024
Union Hospital
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Zhejiang Sci-Tech University
2023
Autophagy dysfunction is a common feature in neurodegenerative disorders characterized by accumulation of toxic protein aggregates. Increasing evidence has demonstrated that activation TFEB (transcription factor EB), master regulator autophagy and lysosomal biogenesis, can ameliorate neurotoxicity rescue neurodegeneration animal models. Currently known activators are mainly inhibitors MTOR (mechanistic target rapamycin [serine/threonine kinase]), which, as cell growth metabolism, involved...
BackgroundUltrasound is a critical non-invasive test for preoperative diagnosis of ovarian cancer. Deep learning making advances in image-recognition tasks; therefore, we aimed to develop deep convolutional neural network (DCNN) model that automates evaluation ultrasound images and facilitate more accurate cancer than existing methods.MethodsIn this retrospective, multicentre, diagnostic study, collected pelvic from ten hospitals across China between September 2003, May 2019. We included...
The blockade of immune checkpoints by anti-receptor and/or anti-ligand mAb is one the most promising approaches to cancer immunotherapy. interaction between Ig-like transcript 3 (ILT3), a marker tolerogenic dendritic cells, also known as LILRB4/LIR5/CD85k, and its still unidentified ligand on surface activated human T cells potentially important for checkpoint blockade. To identify ILT3 ligand, we generated immunizing mice with Jurkat acute cell leukemia, which binds ILT3.Fc membrane. Flow...
Background Recent studies have highlighted the importance of cross-talk along gut-brain axis in regulating inflammatory nociception, responses, and immune homeostasis. The gut microbiota, particularly its bacterial composition, plays a crucial role development function system. Moreover, metabolites produced by microbiota can significantly impact both systemic responses central nervous system (CNS) immunity. Sodium butyrate is key metabolite and, as histone deacetylase inhibitor, enhance...
We aimed to analyze the phenotype of tumor-infiltrating lymphocytes (TILs) and non-tumor infiltrating (NILs) in HCC tissues, evaluate relationships between changes these cells prognosis HCC.Lymphocytes were isolated from corresponding tissues tested by flow cytometry. For comparison, clinical parameters analyzed.Compared with tissue, tumor tissue had a lower intensity NK, NKT CD8+T cell infiltration. TILs higher CD4+CD25+Foxp3+regulatory T (Treg cells) infiltration compared that NILs. The...
Induced B7-H1 expression in the tumor microenvironment initiates adaptive resistance, which impairs immune functions and leads to escape from destruction. Antibody blockade of B7-H1/PD-1 interaction overcomes leading regression advanced human cancers survival benefits a significant fraction patients. In addition cancer cells, is expressed on dendritic cells (DCs), but its role DC less understood. DCs can present multiple antigens (Ags) stimulate dominant or subdominant T cell responses....
The mechanism of BCA against WS-UPM-induced oxidative damage.
Abstract PARP inhibitors (PARPi) are efficacious in treating high-grade serous ovarian cancer (HG-SOC) with homologous recombination (HR) deficiency. However, they exhibit suboptimal efficiency HR-proficient cancers. Here, we found that the expression of CCAAT/enhancer-binding protein β (C/EBPβ), a transcription factor, was inversely correlated PARPi sensitivity vitro and vivo, both condition. High C/EBPβ enhanced tolerance; treatment turn induced expression. directly targeted upregulated...
This real-world study explores the effect of coronavirus disease 2019 (COVID-19) inactivated vaccines on prevention asymptomatic or mild Delta Omicron variant infections progressing to pneumonia. Association between severe acute respiratory syndrome 2 (SARS-CoV-2) pneumonia cases and vaccination was measured with a multivariable logistic regression, stratified by genotype age groups. We recruited 265 (111 (41.9%) infected 154 (58.1%) variants). There were 22 individuals, 156 without...
Abstract Cancer-associated fibroblasts (CAFs) play significant roles in drug resistance through different ways. Antitumor therapies, including molecular targeted interventions, not only effect tumor cells but also modulate the phenotype and characteristics of CAFs, which can turn blunt therapeutic response. Little is known about how stromal respond to poly (ADP-ribose) polymerase inhibitors (PARPis) ovarian cancer (OC) subsequent effects on cells. This a study evaluate CAFs react PARPis...
Head and neck squamous cell carcinoma (HNSCC) is an invasive malignancy with high worldwide mortality. Growing evidence has indicated a pivotal correlation between HNSCC prognosis immune signature. This study investigated immune-related gene pairs (IRGPs) signature to predict the prognostic value of patients. We constructed IRGPs via integrating multiple IRG expression data sets. Moreover, we established predictive model base on for HNSCC, utilized multidimensional bioinformatics methods...
BACKGROUND:Head and neck squamous cell carcinoma (HNSC) is an invasive malignancy with a high worldwide mortality, despite considerable recent advancements in diagnosis treatment. Increasing evidence indicates that the Lamin C (LAMC) gene family associated progression of diverse cancers, nevertheless, this association not well understood. MATERIAL AND METHODS:A systematic study addressing expression prognostic value LAMC, relationship between LAMC tumor immune response HNSC was done....
Resistin is an endogenous ligand of Toll-like receptor 4 that activates several inflammatory signals. But the physiological function resistin in community-acquired pneumonia (CAP) remains unknown. The goal this research was to explore associations between serum and severity prognosis CAP patients through a retrospective cohort study.All 212 106 healthy cases were enrolled. Demographic characteristics extracted. Serum determined via enzyme-linked immunosorbent assay. tracked patients.Serum on...
Abstract Background To compare the post-operative pain and quality of life patients who underwent total thoracoscopic surgery (TTS) or conventional full-sternotomy (CFS) for aortic valve replacement (AVR). Methods We reviewed records 223 consecutive AVR with either TTS CFS from January 2018 to December 2022. used a visual analogue scale (VAS) Short Form-36 Health Survey (SF-36) measure life, respectively. also compared operative data clinical outcomes between two groups. Results The group...
Abstract Multiple sclerosis (MS) is a chronic autoimmune disease of the CNS that characterized by demyelination, axonal loss, gliosis, and inflammation. The murine model MS experimental encephalopathy (EAE) induced immunization mice with myelin oligodendrocyte glycoprotein (MOG)35–55. Ig-like transcript 3 (ILT3) an inhibitory cell surface receptor expressed tolerogenic human dendritic cells. In this study, we show recombinant ILT3.Fc protein binds to immune cells inhibits release...
Early immune reconstitution is crucial to successful outcomes after allogeneic stem cell transplantation (allo-HSCT). However, in T cell-replete HSCT, the impact of natural killer (NK) cells on outcome and factors influencing early NK remain unclear.In this retrospective study, we analyzed 128 patients with hematological malignancies who received first allo-HSCT between May 2019 September 2021. After application a conditioning regimen, prophylaxis for graft versus host disease (GVHD),...