A5052484642- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Gut microbiota and health
- Anomaly Detection Techniques and Applications
- Parathyroid Disorders and Treatments
- Ginseng Biological Effects and Applications
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Tryptophan and brain disorders
- Natural product bioactivities and synthesis
- Oral microbiology and periodontitis research
- Medicinal Plant Pharmacodynamics Research
- Alzheimer's disease research and treatments
- Advanced Battery Technologies Research
- Biological and pharmacological studies of plants
- Fault Detection and Control Systems
- Genetic Syndromes and Imprinting
- Iron Metabolism and Disorders
- Probiotics and Fermented Foods
- RNA and protein synthesis mechanisms
- Phytochemical Studies and Bioactivities
- Trace Elements in Health
- Domain Adaptation and Few-Shot Learning
Sichuan University
2016-2025
University of Chinese Academy of Sciences
2020-2024
Technology and Engineering Center for Space Utilization
2020-2024
Chinese Academy of Sciences
2020-2024
West China Hospital of Sichuan University
2024
Nantong University
2007-2021
China National Nuclear Corporation
2016
Hong Kong Polytechnic University
2005-2012
State Key Laboratory of Biotherapy
2009-2010
University of British Columbia
2008
ProBiotic-4 is a probiotic preparation composed of Bifidobacterium lactis, Lactobacillus casei, bifidum, and acidophilus. This study aims to investigate the effects on microbiota-gut-brain axis cognitive deficits, explore underlying molecular mechanism using senescence-accelerated mouse prone 8 (SAMP8) mice. was orally administered 9-month-old SAMP8 mice for 12 weeks. We observed that significantly improved memory cerebral neuronal synaptic injuries, glial activation, microbiota composition...
Ischemic brain injury is associated with neuroinflammatory response, which essentially involves glial activation and neutrophil infiltration. Transcription factors nuclear factor-κB (NF-κB) signal transducer activator of transcription 3 (STAT3) contribute to ischemic processes secondary by releasing proinflammatory mediators. Kaempferol-3-O-rutinoside (KRS) kaempferol-3-O- glucoside (KGS) are primary flavonoids found in Carthamus tinctorius L. Recent studies demonstrated that KRS protected...
Summary Introduction Mean platelet volume (MPV) and (PLT) count are the two major parameters that reflect functions activities of PLTs. The associations MPV PLT with occurrence prognosis stroke have not been fully clarified. This study aimed to investigate association development first‐ever ischemic hemorrhagic in order provide evidence for early diagnosis treatment both strokes. Methods included 281 164 patients between 2010 2012. All participants received routine blood tests within 2 h...
Abstract Alzheimer's disease (AD) is the most prevalent type of dementia, characterized by presence amyloid‐β (Aβ) plaques. We previously reported that Klotho lowered Aβ levels in brain and protected against cognitive deficits amyloid precursor protein/presenilin 1(APP/PS1) mice. However, underlying mechanism remains unclear. In this study, we induced intracerebral overexpression 13‐month‐old APP/PS1 mice injecting lentivirus carried full‐length mouse cDNA lateral ventricle brain. examined...
Glioma, the most prevalent primary tumor of central nervous system, is characterized by a poor prognosis and high recurrence rate. The interplay between microbes, such as gut microbiota, host has underscored significant impact microorganisms on disease progression. Bifidobacterium, beneficial bacterial strain found in human animal intestines, exhibits inhibitory effects against various diseases. However, existing body evidence pertaining to influence Bifidobacterium glioma remains...
Glioma is a common primary aggressive tumor with limited clinical treatment. Recently, growing research suggests that gut microbiota involved in progression, and several probiotics can inhibit growth. However, evidence for the effect of on glioma lacking. Here, we found Bifidobacterium (B.) lactis combined Lactobacillus (L.) plantarum reduced volume, prolonged survival time repaired intestinal barrier damage an orthotopic mouse model glioma. Experiments demonstrated B. L. suppressed PI3K/AKT...
Abstract Background G-quadruplex DNA (G4) is a non-canonical structure forming in guanine-rich regions, which play vital role cancer biology and are now being acknowledged both nuclear mitochondrial (mt) genome. However, the impact of G4-based targeted therapy on mt genome, affecting function its underlying mechanisms remain largely unexplored. Methods The action therapeutic effects G4-binding platinum(II) complex, Pt-ttpy, mitochondria were conducted through comprehensive approaches with...
The present study investigated the effect of Z-Ligustilide (LIG), a characterized 3-n-alkyphthalide derivative existed in many medical Umbelliferae plants, on permanent focal ischemic brain injury rats. Focal cerebral ischemia was induced by occlusion middle artery (MCA) for 24 h. LIG (20, or 80 mg/kg), orally administered at 2 h after ischemia, reduced infarct volumes 48.29% and 84.87% respectively compared to control group as visualized 2,3,5-triphenyltetrazolium chloride (TTC) staining...
Antithrombotic therapy has become an important goal for the treatment of ischemic disorders such as cerebral ischemia. Our recent studies found that Z-ligustilide (LIG), a characterized 3-n-alkylphthalide constituent Radix Angelica sinensis essential oil, exerted significant neuroprotection against damage in several animal models. The present study evaluated antithrombotic activity LIG and its effect on platelet aggregation coagulation time. (10 or 40 mg/kg) was intragastrically administered...
Emerging evidence suggests that alpha-processing single transmembrane proteins, amyloid precursor protein (APP) and anti-aging Klotho, are likely to be involved in the progression of Alzheimer's disease (AD). The natural phthalide Ligustilide (LIG) has been demonstrated protect against aging- amyloid-β (Aβ)-induced brain dysfunction animal models. present study is investigate effects LIG on cognitive deficits metabolism both APP Klotho its underlying mechanism AD double-transgenic (APP/PS1)...
Aging is the greatest independent risk factor for occurrence of stroke and poor outcomes, at least partially through progressive increases in oxidative stress inflammation with advanced age. Klotho an antiaging gene, expression which declines may protect against neuronal damage that induced by glutamate. The present study investigated effects klotho overexpression knockdown intracerebroventricular injection a lentiviral vector encoded murine (LV-KL) or rat short-hairpin RNA (LV-KL shRNA) on...