A5100602497- COVID-19 Clinical Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Long-Term Effects of COVID-19
- Nanoparticle-Based Drug Delivery
- Ovarian cancer diagnosis and treatment
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- COVID-19 and healthcare impacts
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Acute Ischemic Stroke Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Sepsis Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Thyroid Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Microtubule and mitosis dynamics
- Extracellular vesicles in disease
- Metabolomics and Mass Spectrometry Studies
- Venous Thromboembolism Diagnosis and Management
Zhejiang Chinese Medical University
2024-2025
Beijing Radiation Center
2015-2025
Chinese PLA General Hospital
2023-2025
Hubei Provincial Hospital of Traditional Chinese Medicine
2025
Hubei University of Chinese Medicine
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Capital Medical University
2017-2024
Tongji Hospital
2016-2024
Beijing YouAn Hospital
2017-2024
Tongji University
2024
Abstract Soaring cases of coronavirus disease (COVID-19) are pummeling the global health system. Overwhelmed facilities have endeavored to mitigate pandemic, but mortality COVID-19 continues increase. Here, we present a risk prediction model for (MRPMC) that uses patients’ clinical data on admission stratify patients by risk, which enables physiological deterioration and death up 20 days in advance. This ensemble is built using four machine learning methods including Logistic Regression,...
BackgroundUltrasound is a critical non-invasive test for preoperative diagnosis of ovarian cancer. Deep learning making advances in image-recognition tasks; therefore, we aimed to develop deep convolutional neural network (DCNN) model that automates evaluation ultrasound images and facilitate more accurate cancer than existing methods.MethodsIn this retrospective, multicentre, diagnostic study, collected pelvic from ten hospitals across China between September 2003, May 2019. We included...
Importance The effects of moderate systolic blood pressure (SBP) lowering after successful recanalization with endovascular therapy for acute ischemic stroke are uncertain. Objective To determine the futility lower SBP targets (<140 mm Hg or 160 Hg) compared a higher target (≤180 Hg). Design, Setting, and Participants Randomized, open-label, blinded end point, phase 2, clinical trial that enrolled 120 patients who had undergone at 3 US comprehensive centers from January 2020 to...
Tumor-associated macrophages (TAMs) generally display an immunosuppressive M2 phenotype and promote tumor progression metastasis, suggesting their potential value as a target in cancer immunotherapy. Chlorogenic acid (CHA) has been identified potent immunomodulator that promotes the polarization of TAMs from to M1 phenotype. However, rapid clearance vivo low accumulation have compromised immunotherapeutic efficacy CHA clinical trials. In this study, mannosylated liposomes are developed for...
The ferocious global assault of COVID-19 continues. Critically ill patients witnessed significantly higher mortality than severe and moderate ones. Herein, we aim to comprehensively delineate clinical features explore risk factors developing critical disease.This is a Mini-national multicenter, retrospective, cohort study involving 2,387 consecutive inpatients that underwent discharge or death between January 27 March 21, 2020. After quality control, 2,044 were enrolled. Electronic medical...
Background: Tumor-associated macrophages (TAMs) are critical in tumor progression and metastasis. Selective targeting of TAMs holds great potential to ameliorate the immunosuppressive microenvironment enhance efficacy antitumor therapy. Various liposomes have been developed target via cell-specific surface receptors either deplete or re-educate TAMs. Since immuno-stimulation often initiates with interaction nanocarriers innate immunity cells such as macrophages, intrinsic impact drug-free on...
Background Chimeric antigen receptor T (CAR-T) cell therapy has made significant advances for hematological malignancies but encounters obstacles in the treatment of solid tumors mainly due to tumor immunosuppressive microenvironment. Methods Immunohistochemistry analysis was performed examine cellular expression nectin adhesion molecule-4 (Nectin4) and fibroblast activation protein (FAP) a variety malignant tumors. Then, we engineered fourth-generation Nectin4-targeted CAR-T (Nectin4-7.19...
Obesity and related metabolic syndromes have been recognized as important disease risks, in which the role of adipokines cannot be ignored. Adiponectin (ADP) is one key with various beneficial effects, including improving glucose lipid metabolism, enhancing insulin sensitivity, reducing oxidative stress inflammation, promoting ceramides degradation, stimulating adipose tissue vascularity. Based on those, it can serve a positive regulator many syndromes, such type 2 diabetes (T2D),...
The aims of this study were to prepare a baicalein self-microemulsion with baicalein-phospholipid complex as the intermediate (BAPC-SMEDDS) and compare its effects those conventional (CBA-SMEDDS) on oral absorption lymphatic transport.Two SMEDDS characterized by emulsifying efficiency, droplet size, zeta potential, cloud point, dilution stability, physical in vitro release lipolysis. Different formulations 40 mg/kg orally administered Sprague-Dawley rats investigate their respective...
Background Mesenteric lymph nodes (MLNs) are critical draining of the immune system that accommodate more than half body’s lymphocytes, suggesting their potential value as a cancer immunotherapy target. Therefore, efficient delivery immunomodulators to MLNs holds great for activating responses and enhancing efficacy antitumor immunotherapy. Self-microemulsifying drug systems (SMEDDS) have attracted increasing attention improving oral bioavailability by taking advantage intestinal lymphatic...
The occurrence and development of tumors require the metabolic reprogramming cancer cells, namely alteration flux in an autonomous manner via various pathways to meet increased bioenergetic biosynthetic demands. Tumor cells consume large quantities nutrients produce related metabolites their metabolism; this leads remodeling tumor microenvironment (TME) better support growth. During TME remodeling, immune cell metabolism antitumor activity are affected. This further escape from surveillance...
The present study aimed to explore the combined associations of depression and cognitive impairment with functional disability mortality, whether joint effects on mortality were influenced by disability.A total 2,345 participants aged 60 above from 2011-2014 cycle National Health Nutrition Examination Survey (NHANES) included in analyses. Questionnaires used evaluated depression, global function (including activities daily living (ADLs), instrumental (IADLs), leisure social (LSA), lower...
VX680 is a potent and selective inhibitor that targets the Aurora kinase family. The p38 mitogen-activated protein (MAPK) regulates large number of cellular pathways plays an important role in regulation cell survival apoptosis. This study aimed to evaluate effect on cervical cancer cells investigate whether effects apoptosis are enhanced by ablation MAPK activation. results suggested inhibited proliferation causing G2/M phase arrest endoreduplication apoptotic was attenuated activation...
Treatment of ovarian cancer (OC) remains the biggest challenge among gynecological malignancies. Immune checkpoint blockade therapy is promising in many cancers but shows low response rates OC because its heterogeneity. Although biological and molecular heterogeneity has been extensively investigated, immune microenvironment elusive. We have collected expression profiles 3071 patients from 22 publicly available datasets. CIBERSORT was applied to infer infiltration fraction cells 2086 with P...
Abstract Platelets are reprogrammed by cancer via a process called education, which favors development. The transcriptional profile of tumor-educated platelets (TEPs) is skewed and therefore practicable for detection. This intercontinental, hospital-based, diagnostic study included 761 treatment-naïve inpatients with histologically confirmed adnexal masses 167 healthy controls from nine medical centers (China, n = 3; Netherlands, 5; Poland, 1) between September 2016 May 2019. main outcomes...
Patients with malignancy were reportedly more susceptible and vulnerable to Coronavirus Disease 2019 (COVID-19), witnessed a greater mortality risk in COVID-19 infection than noncancerous patients. But the role of immune dysregulation malignant patients on poor prognosis has remained insufficiently investigated. Here we conducted retrospective cohort study that included 2,052 hospitalized (Cancer, n = 93; Non-cancer, 1,959), compared immunological characteristics both cohorts. We used...
Abstract: Tanshinone IIA (Tan IIA) (C 19 H 18 O 3 ) is one of the major active lipophilic components in a conventional Chinese medicine called danshen, and it has long been used People's Republic China other neighboring countries to treat patients suffering from inflammatory bowel disease (IBD). Previous experiments by many teams determined which mechanism Tan relevant treatment IBD associated with inflammation pregnane X receptor (PXR). The current study demonstrated that an efficacious PXR...
This study aims to establish a hypobaric hypoxia-induced immune injury model and investigate the intervention therapeutic effects of Astragaloside IV (AS-IV). simulated hypoxia stimulation in mice at an altitude 7000 m on plateau for 1, 3, 5, 7 days. HE staining transcriptomic analysis were performed mouse spleens. In addition, AS-IV was selected prevention treatment, validated by flow cytometry, ELISA, Q-PCR. The results showed that under hypoxic conditions 5 days, peripheral blood...