A5003924177- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Stroke Rehabilitation and Recovery
- Cerebral Venous Sinus Thrombosis
- Long-Term Effects of COVID-19
- Neuroscience and Neuropharmacology Research
- Renal and Vascular Pathologies
- Molecular Biology Techniques and Applications
- Melanoma and MAPK Pathways
- Moyamoya disease diagnosis and treatment
- Microtubule and mitosis dynamics
- COVID-19 and healthcare impacts
- PI3K/AKT/mTOR signaling in cancer
- Gene expression and cancer classification
- Vestibular and auditory disorders
- EEG and Brain-Computer Interfaces
- Metal complexes synthesis and properties
- Neural dynamics and brain function
- Vascular Anomalies and Treatments
- Tracheal and airway disorders
University of Cincinnati Medical Center
2014-2025
Rabin Medical Center
2024
University of Cincinnati
2013-2023
Barro Colorado Island
2023
Neurology, Inc
2021
The Royal Melbourne Hospital
2019
The University of Melbourne
2019
Icahn School of Medicine at Mount Sinai
2019
New York Proton Center
2017
Cincinnati Children's Hospital Medical Center
2017
Thrombectomy, primarily with stent retrievers or without adjunctive aspiration, provided clinical benefit across multiple prospective randomized trials. Whether this is exclusive to unclear.THERAPY (The Randomized, Concurrent Controlled Trial Assess the Penumbra System's Safety and Effectiveness in Treatment of Acute Stroke; NCT01429350) was an international, multicenter, prospective, (1:1), open label, blinded end point evaluation, concurrent controlled trial aspiration thrombectomy after...
Importance The effects of moderate systolic blood pressure (SBP) lowering after successful recanalization with endovascular therapy for acute ischemic stroke are uncertain. Objective To determine the futility lower SBP targets (<140 mm Hg or 160 Hg) compared a higher target (≤180 Hg). Design, Setting, and Participants Randomized, open-label, blinded end point, phase 2, clinical trial that enrolled 120 patients who had undergone at 3 US comprehensive centers from January 2020 to...
OBJECTIVE: Morphological indications of abnormal circuitry have been detected in the prefrontal neuropil patients with schizophrenia. The authors tested hypothesis that schizophrenia is associated smaller dendritic field size layer V pyramidal neurons cortex. METHOD: Tissue from area 10 a mean postmortem interval 5.7 hours was obtained 15 subjects chronic and 18 normal comparison subjects. After Golgi impregnation, basilar estimated for by ring intersection analysis. RESULTS: had 40% fewer...
Profound impairment in social interaction is a core symptom of autism, severe neurodevelopmental disorder. Deficits can include lack interest contact and low levels approach proximity to other children. In this study, three‐chambered choice task was used evaluate sociability novelty preference five lines mice with mutations genes implicated autism spectrum disorders. Fmr1 tm1Cgr/Y ( −/y ) represent model for fragile X, mental retardation syndrome that partially comorbid autism. We tested on...
Fragile X syndrome (FXS) is the most common form of inherited mental retardation. Observed neuropathologies associated with FXS include abnormal length, morphology, and density dendritic spines, reported in individuals Fmr1 knockout (KO) mice, an animal model FXS. To date, however, these have been studied KO mice bred a FVB background (a strain genetic mutations that complicate interpretation results) findings inconsistent. Here, Golgi–Cox impregnation was used to investigate spines on layer...
Background and Purpose— Dizziness can herald a cerebrovascular event. The ABCD 2 score predicts the risk of stroke after transient ischemic attack partly by distinguishing from mimics. We evaluated whether this would also identify events among emergency department patients with dizziness. Methods— retrospectively identified consecutive adults presenting to university primary symptom dizziness, vertigo, or imbalance. Two neurologists independently reviewed medical records determine was caused...
Background and Purpose: Anecdotal evidence suggests that the coronavirus disease 2019 (COVID-19) pandemic mitigation efforts may inadvertently discourage patients from seeking treatment for stroke with resultant increased morbidity mortality. Analysis of regional data, while hospital capacities acute care remained fully available, offers an opportunity to assess this. We report Stroke Team activations reperfusion treatments during COVID-19 activities. Methods: Using case log data...
emergent stroke team contact, and initiation of EVT in eligible patients
OBJECTIVE Many low-risk unruptured intracranial aneurysms (UIAs) are followed for growth with surveillance imaging. Growth of UIAs likely increases the risk rupture. The incidence and factors UIA or de novo aneurysm formation require further research. authors retrospectively identify annual in an protocol. METHODS Over 11.5-year period, recommended imaging to 192 patients 234 UIAs. was assessed. With logistic regression, patient compliance protocol RESULTS During 621 patient-years follow-up,...
Objectives/Goals: We hypothesized that the bulk transcriptomic profiling of blood collected from within ischemic vasculature during an acute stroke with large vessel occlusion (LVO) will contain unique biomarkers are different peripheral circulation and may provide much-needed insight into underlying pathogenesis LVO in humans. Methods/Study Population: The Inflammation Large Vessel Ischemic Stroke pilot study prospectively enrolled patients ≥ 18 years age anterior LVO, treated endovascular...
Abstract Purpose An accurate mathematical model of intracranial aneurysm (IA) mechanics is great value for its potential utility in assessing probability IA rupture. Such a spherical IAs has been developed which predicts wall-thickness-to-IA-radius ratio (WTR) 6.1 × 10 −3 at To our knowledge, no further work done to validate this with clinical data. We aim assess the accuracy and rupture mechanics. Methods Aneurysm height, width, neck diameter, vessel radius were measured on radiologic...
Introduction Analysis of computed tomography perfusion (CTP) studies before and after superficial temporal artery to middle cerebral (STA-MCA) bypass is warranted better understand steno-occlusive pathology. Methods Retrospective review was performed STA-MCA patients with disease CTP surgery. parameters were evaluated for change bypass. Results A total 29 hemispheres bypassed in 23 patients. After bypass, mean transit time (MTT) peak (TTP) improved. When analyzed as a ratio the contralateral...
Computed tomographic angiography and conventional provide timely vascular anatomic information in patients with stroke. However, iodinated contrast dye may cause acute kidney injury (AKI). Within a large, biracial population, we examined in-hospital incidence of new or worsening disease stroke its association administration intravenous dye.All adult residents the Greater Cincinnati/Northern Kentucky region ischemic intracerebral hemorrhage who presented to an emergency department 2010 were...
Dizziness is a frequent reason for neuroimaging and neurological consultation, but little known about the utility of either practice. We sought to characterize patterns yield consultation dizziness in emergency department (ED).We retrospectively identified consecutive adults presenting an academic ED from 2007 2009, with primary complaint dizziness, vertigo, or imbalance. Neurologists reviewed medical records determine clinical characteristics, whether study (head computed tomography [CT]...
While tumor emboli are a rare cause of stroke in cancer patients, they highlight the importance gross observations and pathological assessments evaluation clots. In this case report, 70-year-old male with type 2 diabetes mellitus coronary artery disease presented acute left-sided weakness. He was clinically diagnosed given alteplase at 1.5 h from last known normal. then underwent CT angiography that showed right internal carotid occlusion immediate thrombectomy. The recovered clot white...