A5101496800- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- Protein Interaction Studies and Fluorescence Analysis
- Traditional Chinese Medicine Studies
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Mass Spectrometry Techniques and Applications
- Glioma Diagnosis and Treatment
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Hemoglobin structure and function
- Mycotoxins in Agriculture and Food
- Traditional Chinese Medicine Analysis
- Estrogen and related hormone effects
- Cell death mechanisms and regulation
- Virus-based gene therapy research
- Intracerebral and Subarachnoid Hemorrhage Research
- Monoclonal and Polyclonal Antibodies Research
- Pharmacogenetics and Drug Metabolism
- High Altitude and Hypoxia
- Alzheimer's disease research and treatments
- Total Knee Arthroplasty Outcomes
- Aluminum toxicity and tolerance in plants and animals
- Child Abuse and Related Trauma
University of Electronic Science and Technology of China
2025
Massachusetts General Hospital
2008-2025
Center for Pain and the Brain
2025
Tianjin University
2011-2025
Institute of Optics and Electronics, Chinese Academy of Sciences
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2024
First Affiliated Hospital of Henan University of Science and Technology
2008-2021
Henan University of Science and Technology
2011-2015
Lanzhou Army General Hospital
2008-2014
Korea Research Institute of Bioscience and Biotechnology
2011
Abstract Background: Clinical diagnoses were correlated with results of a Co(II)–albumin binding assay in 167 patients treated at an emergency department health maintenance organization. Methods: Patients evaluated as being nonischemic or potentially ischemic through standard coronary disease indicators [creatine kinase (CK), CK-MB, cardiac troponin I, and electrocardiographic findings] tested by assay. Samples anonymously, the study was double-blinded. The sensitivity specificity this for...
Necroptosis is a newly identified type of programmed necrosis initiated by the activation tumor factor alpha (TNFalpha)/Fas. Necrostatin-1 specific inhibitor necroptosis that reduces ischemic tissue damage in experimental stroke models. We previously reported decreased and improved functional outcome after controlled cortical impact (CCI) mice deficient TNFalpha Fas. Hence, we hypothesized necrostatin-1 would reduce histopathology improve CCI mice. Compared with vehicle-/inactive...
Human serum albumin (HSA) is a versatile transport protein for endogenous compounds and drugs. To evaluate physiologically relevant interactions between ligands the protein, it necessary to determine locations relative affinities of different their binding site(s). We present site-specific investigation sites on HSA fatty acids (FA), primary physiological ligand protein. Titration with [(13)C]carboxyl-labeled FA was used initially identify three NMR chemical shifts that are associated...
Background: All versions of the Montreal Cognitive Assessment (MoCA) lack population-based data 80-plus individuals. The norms and cut-off scores for mild cognitive impairment (MCI) dementia MoCA are different among five Chinese version
Axial flow fans, used for heat dissipation in electronic equipment, may generate significant electromagnetic interference during PWM speed regulation. Due to its multiple radiation sources and relatively smaller size compared the prediction model equipment-level EMC analysis often involves a huge number of grids, which leads computational difficulties inefficiencies, thus an equivalent modeling method fan is presented. First, detailed field-circuit coupling from winding driving circuits...
Background Acute brain injury is an important health problem. Given the critical position of caspase 8 at crossroads cell death pathways, we generated a new viable mouse line (Ncasp8−/−), in which gene encoding was selectively deleted neurons by cre-lox system. Methodology/Principal Findings Caspase deletion reduced rates neuronal primary cultures and whole organotypic coronal slice prepared from 4 month old mice cultivated up to 14 days vitro. Treatments with recombinant murine TNFα (100...
We previously reported that tumor necrosis factor-alpha (TNF-alpha) and Fas receptor induce acute cellular injury, tissue damage, motor cognitive deficits after controlled cortical impact (CCI) in mice (Bermpohl et al. 2007 ); however, the TNF receptors (TNFR) involved are unknown. Using a CCI model novel mutant deficient TNFR1/Fas, TNFR2/Fas, or TNFR1/TNFR2/Fas, we tested hypothesis combination of TNFR2/Fas is protective, whereas TNFR1/Fas detrimental CCI. Uninjured knockout (KO) showed no...
To investigate the effect of acupuncture on women with premature ovarian failure (POF), prospective consecutive case series study was applied. 31 POF were included; all patients treated once every other day, three times a week for months. Acupoints, GV 20, 24, GB 13, CV 3, 4, BL 23, 32, ST 25, 28, 29, 36, SP 6, KI and LR selected. Serums FSH, E 2 , LH level, Self‐Rating Anxiety Scale (SAS), Kupperman score measured at baseline end treatment; menstrual cycle recorded during one‐month...
Blockchain technology is revolutionizing various industries through decentralized architecture and secure transaction mechanisms, yet its core application—smart contracts—faces increasingly sophisticated security threats. Recognizing the critical need for enhanced protection in this emerging domain, paper introduces TPH-Fuzz, a two-phase hybrid fuzzing framework designed to overcome current limitations vulnerability detection. TPH-Fuzz combines global exploration with local targeting. It...
rhEPO is frequently used in clinical practice to treat anemia. However, recently has been reported accelerate tumor growth, progression and metastasis. Many pituitary adenoma patients, particularly those with macroprolactinomas, tend have anemia may need therapy. To date, whether deleterious effects on adenomas not defined. Here we demonstrated for the first time that human are EPOR negative tumors accelerated growth of MMQ xenografts via enhancement angiogenesis vivo, whereas displayed no...
According to several studies, some nuclear magnetic resonance (NMR) structures are of lower quality, less reliable and suitable for structural analysis than high-resolution X-ray crystallographic structures. We present a public database 2405 refined NMR solution [statistical torsion angle potentials (STAP) refinement the database, http://psb.kobic.re.kr/STAP/refinement] from Protein Data Bank (PDB). A simulated annealing protocol was employed obtain with target potentials, including newly...
We investigated the prognostic significance of nidogen-1 (NID1) in glioma. Oncomine, GEPIA, UALCAN, CCGA database analyses showed that NID1 transcript levels were significantly upregulated multiple cancer types, including gliomas. Quantitative RT-PCR confirmed expression was glioma tissues compared to paired adjacent normal brain tissue samples (n=9). silencing enhanced vitro apoptosis and temozolomide sensitivity U251 U87-MG cells. Protein-protein interaction network analysis using STRING...
Propofol and halothane are clinically used general anaesthetics, which transported primarily by HSA (human serum albumin) in the blood. Binding characteristics therefore of interest for both pharmacokinetics pharmacodynamics these drugs. We characterized anaesthetic–HSA interactions solution using elution chromatography, ITC (isothermal titration calorimetry), hydrogen-exchange experiments geometric analyses high-resolution structures. affinity propofol to was determined have a Kd 65 µM...
Abstract Previous studies have shown that many arachidonic acid metabolites bind to human serum albumin (HSA) and the metabolism of these molecules is altered as a result binding. The present study attempted gain insights into mechanisms by which prostaglandins bound subdomain 2A HSA are metabolized catalytic processes. breakdown prostaglandin 15‐keto‐PGE 2 15‐keto‐PGA 15‐keto‐PGB in presence wild‐type number mutants was examined using previously validated spectroscopic method monitors...
O6-methylguanine-DNA methyltransferase (MGMT) activity is responsible for temozolomide (TMZ) resistance in patients harboring aggressive pituitary adenomas. Recently, disulfiram (DSF) has been shown to induce the loss of MGMT protein and increase TMZ efficacy glioblastoma cells, while CD133+ nestin+ cells isolated from cell population have implicated as adenoma stem‑like cells. However, whether DSF able potentiate cytotoxic effects on human not investigated date. In present study, phenotype...
Objective. We aim to study the therapeutic effects of scraping by investigating changes temperature and local blood perfusion volume in healthy subjects after stimulation, explore mechanism stimulation from points microcirculation energy metabolism. Methods. Twenty-three health were included this study. Local body surface was detected at 5 min before 0, 15, 30, 60 90 using Laser Doppler imager infrared thermograph. Results. Significant increase noted area within minutes compared baseline...
Multiple binding sites for anaesthetics in HSA (human serum albumin) make solution studies difficult to interpret. In the present study, we expressed wild-type domain 3 (wtHSAd3), a peptide with two known anaesthetic yeast expression system. We also site-directed mutant of (Y411Wd3). The stability and secondary structure constructed fragments were determined by HX (hydrogen–tritium exchange) CD spectroscopy. general anaesthetics, 2-bromo-2-chloro-1,1,1-trifluoroethane propofol, wtHSAd3...
Purpose: Peptide-based high-density lipoprotein (pHDL) structurally and functionally resembles the natural HDL as anti-atherosclerosis (AS) therapies. Since pHDL contains a large hydrophobic core, this study aims to evaluate potentials of drug carrier efficiency drug-loaded in control AS. Methods: The encapsulation components from plants, including curcumin (Cur) tanshinone IIA (TanIIA), was achieved using one-step microfluidics. Then, morphological features loading efficiencies pHDL-Cur...
To verify the effects of scraping therapy on weightlifting ability by measuring subjective sensation, and changes biomarkers.Five students, who have been trained for 3 years in a sport school China were participated this study. A course was applied to intervene during normal 7-week training programme. The weightlifting, scale rating perceived exertion serum biochemical markers measured before after intervention.Scraping caused significant increase (P < 0.05). level remained stable with...
Patients with Alzheimer's disease (AD) inheriting Apolipoprotein (APOE) ε4 are susceptible to COVID-19, but the underlying mechanism of how such a neurodegenerative promotes respiratory vulnerability viral infections remains insufficiently understood. The uncovering genetic basis COVID-19 outcome holds potential establish models for therapeutic development. Here, using human iPSC-derived type II alveolar epithelial cells (hAECII) from AD patients APOE and healthy individuals, we showed that...