A5100723098- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Neurofibromatosis and Schwannoma Cases
- Sarcoma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Oral and Maxillofacial Pathology
- Pituitary Gland Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Spinal Fractures and Fixation Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer-related molecular mechanisms research
- Spinal Dysraphism and Malformations
- Neuroblastoma Research and Treatments
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Cerebrospinal fluid and hydrocephalus
- Soft tissue tumor case studies
- Ocular Oncology and Treatments
- RNA modifications and cancer
- Facial Nerve Paralysis Treatment and Research
- Epigenetics and DNA Methylation
- Vascular Tumors and Angiosarcomas
- Radiomics and Machine Learning in Medical Imaging
Beijing Tian Tan Hospital
2016-2025
Capital Medical University
2016-2025
Tianjin University
2025
China Agricultural University
2023-2024
National Clinical Research Center for Digestive Diseases
2014-2023
Chinese Institute for Brain Research
2015-2023
Beihai People's Hospital
2023
Capital University
2007-2023
Hong Kong University of Science and Technology
2022
Beijing Institute of Technology
2022
Brainstem gliomas are a heterogeneous group of tumors that encompass both benign cured with surgical resection and highly lethal cancers no efficacious therapies. We perform comprehensive study incorporating epigenetic genomic analyses on large cohort brainstem gliomas, including Diffuse Intrinsic Pontine Gliomas. Here we report, from DNA methylation data, distinct clusters termed H3-Pons, H3-Medulla, IDH, PA-like, each associated unique clinical profiles. The majority within H3-Pons...
Summary. The most common bleeding in haemophilic patients is joints, and joint disability the complications these receiving inadequate treatment. Limited by economy treatment, developing countries face huge challenge to reduce improve quality of life (QoL) children. aim this study was investigate effect low dose secondary prophylaxis China. Children with moderate severe haemophilia from Beijing Hospital, Beijing, China, established disease, were followed for a 12‐week observation period...
OBJECT Intracranial subependymomas are rarely reported due to their extremely low incidence. Knowledge about is therefore poor. This study aimed analyze the incidence and clinical, radiological, pathological features of intracranial subependymomas. METHODS Approximately 60,000 tumors were surgically treated at Beijing Tiantan Hospital between 2003 2013. The authors identified all cases in which patients underwent resection an tumor that was found be examination demonstrated subependymoma...
The aim of this study was to evaluate the pre- and postoperative rehemorrhage risk, neurological function outcome, prognostic factors surgically treated brainstem cavernous malformations (CMs) with long-term follow-up.The authors conducted a retrospective review clinical data from 242 patients CMs that were between 1999 2010. Patient charts, imaging findings, outcomes examined.The included patients, male-to-female ratio 1.3 mean age 32.6 years. modified Rankin Scale scores on admission, at...
OBJECTIVE Skull base chordoma is relatively rare, and a limited number of reports have been published regarding its clinical features. Moreover, the factors associated with extent resection, as well value marginal resection for long-term survival, are still in question this disease. The objective study was to investigate these by evaluating their features surgical outcomes. METHODS A retrospective analysis 238 patients skull chordomas, who met inclusion criteria, performed. This summarized...
Background Diffuse intrinsic pontine gliomas (DIPGs) are rare and fatal pediatric brainstem with no cure. Chimeric antigen receptor (CAR)-engineered natural killer (NK) cells have been proven effective in treating glioblastoma (GBM) preclinical studies. However, there relevant studies on the CAR-NK treatment for DIPG. Our study is first to evaluate anti-tumor activity safety of GD2-CAR NK-92 Methods Five patient-derived DIPG primary neural progenitor cell (PPC) were used access...
The emergence of MDR in plant pathogens is a threat to disease management and leads the use excessive fungicides. Botrytis cinerea particular concern because its has widely emerged field. Understanding genesis first step for controlling MDR. In this study, contribution PSMs been examined. Effective pathogen agroecosystems relies on better understanding how it copes with phytochemicals or
Some studies reported that cerebral developmental venous anomaly (DVA) is often concurrent with cavernous malformation (CM). But there lack of statistical evidence and study bulk cases. The factors associated concurrency are still unknown. purpose this was to determine the prevalence concomitant DVA CM using observational data on Chinese patients analyze concurrency. records all cranial magnetic resonance imaging (MRI) performed between January 2001 December 2012 in Beijing Tiantan Hospital...
Plant pathogens have frequently shown multidrug resistance (MDR) in the field, often linked to efflux and sometimes metabolism of fungicides. To investigate potential role metabolic B. cinerea strains showing MDR, azoxystrobin-sensitive strain B05.10 -resistant Bc242 were treated with azoxystrobin. The degradation half-life azoxystrobin (9.63 days) was shorter than that (28.88 days). Azoxystrobin acid, identified as a metabolite, exhibited significantly lower inhibition rates on colony...
Electrospray ionization (ESI) is a powerful technique with wide range of applications. However, the analytes in low/nonpolar solvents cannot be analyzed directly electrospray ionization-mass spectrometry (ESI-MS), because are incompatible ESI, their low conductivity. To circumvent this problem, we introduce an electrospray-based method termed solvent-assisted (SAESI). With help at tip spray needle, compounds "non-electrospray ionization-friendly" can ionized using (SAESI-MS). The key...
Disordered proliferation and angiogenesis of pulmonary artery endothelial cells is an important stage in the development arterial hypertension. Recent studies revealed that GDF11 (growth differentiation factor 11) induces migration; however, whether directly involved pathogenesis hypertension remains unknown. Here, we found was significantly upregulated activated 2 experimental models cultured cells. Genetic ablation gdf11 rescued features, as demonstrated by right ventricle hypertrophy,...