Adam Taylor
A5071719860- Microstructure and Mechanical Properties of Steels
- Ion-surface interactions and analysis
- Bioinformatics and Genomic Networks
- Advanced Materials Characterization Techniques
- Mass Spectrometry Techniques and Applications
- Metallurgy and Material Forming
- Meat and Animal Product Quality
- Advanced Chemical Sensor Technologies
- High Entropy Alloys Studies
- High Temperature Alloys and Creep
- High-Temperature Coating Behaviors
- Genetics, Bioinformatics, and Biomedical Research
- AI in cancer detection
- Single-cell and spatial transcriptomics
- Metal and Thin Film Mechanics
- Metabolomics and Mass Spectrometry Studies
- Radiomics and Machine Learning in Medical Imaging
- Metallurgical Processes and Thermodynamics
- Computational Drug Discovery Methods
- Cell Image Analysis Techniques
- Bone Tissue Engineering Materials
- Cancer Genomics and Diagnostics
- Hydrogen embrittlement and corrosion behaviors in metals
- Metal Alloys Wear and Properties
- Fusion materials and technologies
Sage Bionetworks
2022-2025
National Physical Laboratory
2018-2024
Deakin University
2011-2024
University of Washington
2014-2018
Friedrich-Alexander-Universität Erlangen-Nürnberg
2018
Seattle University
2015
University of Nottingham
1982-2014
Erich Schmid Institute of Materials Science
2010
Austrian Academy of Sciences
2010
Imperial College Healthcare NHS Trust
2009
In this review, we focus on the saturation microstructure that evolves during severe plastic deformation (SPD). These nanocrystalline or ultrafine-grained microstructures consist predominantly of high-angle boundaries, although low-angle boundaries are also present. Deformation temperature, alloying, and strain path dominant factors controlling grain size in single-phase materials. The decreases significantly with decreasing dependency is stronger at medium homologous temperatures less...
In this study we have explored several aspects of regional analyte suppression in mass spectrometry imaging (MSI) a heterogeneous sample, transverse cryosections mouse brain. Olanzapine was homogeneously coated across the section prior to desorption electrospray ionization (DESI) and matrix-assisted laser (MALDI) imaging. We employed concept tissue extinction coefficient (TEC) assess an on relative its intensity off region. expanded use TEC, by first segmenting anatomical regions using...
Abstract Tumors are intrinsically heterogeneous and it is well established that this directs their evolution, hinders classification frustrates therapy 1–3 . Consequently, spatially resolved omics-level analyses gaining traction 4–9 Despite considerable therapeutic interest, tumor metabolism has been lagging behind development there a paucity of data regarding its spatial organization. To address shortcoming, we set out to study the local metabolic effects oncogene c-MYC , pleiotropic...
Coordinated collaboration is essential to realize the added value of and infrastructure requirements for global image data sharing in life sciences. In this White Paper, we take a first step at presenting some most common use cases as well critical/emerging (including artificial intelligence for) biological medical data, which would benefit tremendously from better frameworks technical, resourcing, legal, ethical aspects). second half paper, paint an ideal world scenario how could work all...
Understanding tumor heterogeneity is a major challenge that was recognized as one of the first Cancer Grand Challenges, with call to provide solutions visualize heterogeneity. The Rosetta team took on this challenge, exploiting advances in spatial-omics approaches centered around mass spectrometry imaging map at cellular and molecular scales different levels resolution. See related article by Bressan et al., p. 16 Stratton 22 Bhattacharjee 28.
<div>Summary:<p>Understanding tumor heterogeneity is a major challenge that was recognized as one of the first Cancer Grand Challenges, with call to provide solutions visualize heterogeneity. The Rosetta team took on this challenge, exploiting advances in spatial-omics approaches centered around mass spectrometry imaging map at cellular and molecular scales different levels resolution.</p><p><a...
<p>Cancer Research UK Rosetta Grand Challenge consortium list of members</p>
<p>Cancer Research UK Rosetta Grand Challenge consortium list of members</p>
Abstract In September 2018, the National Cancer Institute (NCI) launched first phase of Human Tumor Atlas Network (HTAN) under U.S. Moonshot program with goal generating three-dimensional molecular and spatial atlases diverse human tumors characterizing crucial transitions in cancer progression treatment. With over 30 assay types including sequencing, imaging, transcriptomics spanning 58 cancers across 21 organ types, HTAN has delivered a substantial resource to broader research community...
summary Simultaneous 3D articulograph and ultrasonograph techniques were used to monitor the chewing, swallowing, oral soft tissue tongue movements of six subjects whilst consuming varying numbers (1, 2 4) a confectionery product. Modifying number units had variable effect on swallowing during start chewing sequence. The distance, range velocity chin movement significantly lower when 1 unit was consumed compared with 4 middle stage Significant differences in modioli observed initial stages...
Within drug development and pre-clinical trials, a common, significant poorly understood event is the of drug-induced lipidosis in tissues cells. In this manuscript, we describe mass spectrometry imaging strategy, involving repeated analysis tissue sections by DESI MS, positive negative polarities, using MS MS/MS modes. We present results detected distributions administered drug, metabolites, lipid molecules putative marker lipidosis, di-docosahexaenoyl (22:6)-bis(monoacylglycerol) phosphate...