A5010733262- Cell Adhesion Molecules Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Parkinson's Disease Mechanisms and Treatments
- Cancer Cells and Metastasis
- Protease and Inhibitor Mechanisms
- CAR-T cell therapy research
- Memory and Neural Mechanisms
- Meteorological Phenomena and Simulations
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Coral and Marine Ecosystems Studies
- TGF-β signaling in diseases
- Pain Mechanisms and Treatments
- Virus-based gene therapy research
- HER2/EGFR in Cancer Research
- Caveolin-1 and cellular processes
- Climate variability and models
- Geology and Paleoclimatology Research
- Geological and Geophysical Studies
- Tropical and Extratropical Cyclones Research
- Cellular Mechanics and Interactions
Queen Mary University of London
2016-2025
Cancer Institute (WIA)
2016-2025
Cancer Research UK
2008-2024
Garvan Institute of Medical Research
2024
University of Glasgow
2024
Bureau of Meteorology
1979-2018
CRUK Lung Cancer Centre of Excellence
2016
King's College London
2009-2015
University of Southern California
2015
St George Hospital
2015
To examine neuronal activation associated with incentive motivation for cocaine, cocaine-seeking behavior (operant responding without cocaine reinforcement) and Fos expression were examined in rats exposed to saline priming injections and/or a self-administration environment. Rats first trained self-administer or received yoked administration (“control”). They then 21 daily exposures either the environment (“extinction”) different (“no extinction”) available. Extinction training, used...
Unilateral lateral hypothalamlic lesions in rats produce deficits orientation to contralateral visucal, olfactory, whisker-toluch, and somatosetnsory stimuli. This syndrome of sensory neglect appears be involved some the feedinig attack which follow bilateral hypothalamic lesions.
Damage to the mesotelencephalic dopamine-containing projection of rats results in a sensory inattention, characterized by impairments orientation toward somatosensory, visual, and olfactory stimuli. The present experiments were performed establish which branch this dopaminergic system is responsible for these sensorimotor deficits. Two approaches used. In first, individual dopamine-innervated forebrain sites damaged localized 6-hydroxydopamine injection into, or electrolytic lesions of,...
Abstract Worldwide, approximately 405 000 cases of oral cancer (OSCC) are diagnosed each year, with a rising incidence in many countries. Despite advances surgery and radiotherapy, which remain the standard treatment options, mortality rate has remained largely unchanged for decades, 5‐year survival around 50%. OSCC is heterogeneous disease, staged currently using TNM classification, supplemented pathological information from primary tumour loco‐regional lymph nodes. Although patients...
The development of an altered stromal microenvironment is a common feature many tumours including squamous cell carcinoma (SCC), and there increasing evidence that these changes in the stroma, which include increased expression proteases cytokines, may actually promote tumour progression. A finding fibroblasts become ‘activated’ myofibroblasts, expressing smooth muscle actin secreting matrix proteins. We show myofibroblasts are commonly found stroma oral SCC often concentrated at invasive...
The oceans are becoming more acidic due to absorption of anthropogenic carbon dioxide from the atmosphere. impact ocean acidification on marine ecosystems is unclear, but it will likely depend species adaptability and rate change seawater pH relative its natural variability. To constrain variability in reef-water pH, we measured boron isotopic compositions a approximately 300-year-old massive Porites coral southwestern Pacific. Large variations found over 50-year cycles that covary with...
When placed in a tank of water, aged rats (24 to 27 months old) showed marked impairments swimming. Compared with young adult (3 4 old), the older animals moved their limbs less vigorously and were successful keeping heads above water. The young, but not old, maintained position nearly horizontal water surface planed across it. These movement dysfunctions resemble those seen that have sustained injury brain dopamine-containing neurons. swimming reversed by dopamine receptor stimulant...
Direct delivery of the herpes simplex virus thymidine kinase (HSVtk) gene, in combination with prodrug ganciclovir (GC), has been used for treatment localised, inoperable tumours. Several groups have shown that when rodent tumours are ablated vivo suicide genes, antitumour immunity can also be generated. Hence, this approach may useful treating disseminated disease. Here we studied mechanisms associated anti-tumour immunity. In B16 HSVtk+ being killed GSC treatment, observed induction a...
Abstract Methamphetamine (mAMPH), when administered repeatedly to rodents or primates, is neurotoxic some cortical neurons and forebrain dopaminergic serotonergic axon terminals. The aim of the present study was investigate effects a regimen mAMPH on two hippocampus‐dependent memory tasks: object recognition, nonspatial task, Morris water maze, spatial task. Male rats were treated with (4 × 4.0 mg/kg, s.c.) saline trained in recognition task 1 week 3 weeks later. During training, animals...
Immediate-early genes, such as c-fos, are responsive to dopaminergic stimulation in the brain and can have prolonged effects on transcription of other genes. Thus, they may mediate some long-term consequences altered transmission striatal neurons, supersensitivity dopamine its agonists that occurs response denervation. The two receptor families, D1 D2, interact synergistically under normal conditions but independently after treatments induce pronounced agonists. Using immunocytochemical...