A5035174299- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Sarcoma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Oral health in cancer treatment
- Head and Neck Surgical Oncology
- Reconstructive Facial Surgery Techniques
- Bone Tumor Diagnosis and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Tracheal and airway disorders
- Cleft Lip and Palate Research
- Dental Implant Techniques and Outcomes
- Facial Trauma and Fracture Management
- Cardiac, Anesthesia and Surgical Outcomes
- Dysphagia Assessment and Management
- Trauma and Emergency Care Studies
- Ear and Head Tumors
- Effects of Radiation Exposure
- Cardiac tumors and thrombi
- Management of metastatic bone disease
- Respiratory Support and Mechanisms
University College London
2015-2024
University College Hospital
2015-2024
University College London Hospitals NHS Foundation Trust
2013-2024
Royal London Hospital
2003-2023
University of Birmingham
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
AstraZeneca (Brazil)
2020
Abstract Worldwide, approximately 405 000 cases of oral cancer (OSCC) are diagnosed each year, with a rising incidence in many countries. Despite advances surgery and radiotherapy, which remain the standard treatment options, mortality rate has remained largely unchanged for decades, 5‐year survival around 50%. OSCC is heterogeneous disease, staged currently using TNM classification, supplemented pathological information from primary tumour loco‐regional lymph nodes. Although patients...
The incidence of oral squamous cell carcinoma remains high. Oral and oro-pharyngeal carcinomas are the sixth most common cancer in world. Several clinicopathological parameters have been implicated prognosis, recurrence survival, following carcinoma. In this retrospective analysis, 115 T1/T2 OSCC were studied compared to death from tumour-related causes. study protocol was approved by Joint UCL/UCLH committees ethics for human research. patients' data entered onto proformas, which validated...
Human papillomavirus positive (HPV+) head and neck squamous cell carcinoma (HNSCC) is an emerging disease, representing a distinct clinical epidemiological entity. Understanding the genetic basis of this specific subtype cancer could allow therapeutic targeting affected pathways for stratified medicine approach.Twenty HPV+ 20 HPV- laser-capture microdissected oropharyngeal carcinomas were used paired-end sequencing hybrid-captured DNA, 3,230 exons in 182 genes often mutated cancer. Copy...
An understanding of the patterns, spread, and routes tumor invasion mandible is essential in deciding appropriate level extent mandibular resection oral squamous cell carcinoma.A prospective study histologic patterns entry into was performed a consecutive series 100 previously untreated patients.The pattern depended on depth both hard (p =.001) soft tissues =.001). There evidence that related to prognostic indicators disease, such as extracapsular spread from invaded lymph nodes =.03). The...
Human papillomavirus-positive (HPV+) head and neck squamous cell carcinoma (HNSCC) represents a distinct clinical epidemiological condition compared with HPV-negative (HPV-) HNSCC. To test the possible involvement of epigenetic modulation by HPV in HNSCC, we conducted genome-wide DNA-methylation analysis.Using laser-capture microdissection 42 formalin-fixed paraffin wax-embedded (FFPE) HNSCCs, generated profiles 18 HPV+ 14 HPV- samples, using Infinium 450 k BeadArray technology. Methylation...
Guidelines remain unclear over whether patients with early stage oral cancer without overt neck disease benefit from upfront elective dissection (END), particularly those the smallest tumours.
DEP has the potential to be developed into a low-cost, rapid tool for early identification of oral cancer in primary care.
Background Treatment for tumors of the oral cavity and oropharynx disrupts normal swallow function. The ability diet postoperatively varies may be influenced by surgery patient‐related factors. Methods In all, 114 patients treated with without chemoradiotherapy advanced oral/oropharyngeal cancer were recruited. Clinicopathologic tumor parameters reconstruction modalities recorded. Swallow function was determined intake, using Functional Oral Intake Scale (FOIS) pretreatment posttreatment....
Abstract Background Multimodality treatment for head and neck cancer leads to substantial functional esthetic impairment mainly manifested as radiation‐induced skin fibrosis (RIF) in combination with volumetric defects reduction mobility. This study assessed the impact of lipotransfer part secondary surgical procedure(s) patients treated malignancies. Methods Retrospective analysis was performed between 2005 2016. All a history malignancy, multimodal including at least surgery or...
Abstract Background We evaluated the role of 18 FDG PET/CT used to assess response preoperative chemotherapy in patients with primary craniofacial bone sarcomas. Methods Fourteen sarcomas (13 osteosarcoma, 1 spindle cell sarcoma) were retrospectively evaluated. All received up 6 cycles followed by resection tumour. Response treatment was assessed using MRI (RECIST criteria) and (EORTC guidelines), performed at least baseline, after 2-4 pre-operatively. Results The median baseline SUV 10.2...
A MEDLINE search early in 2015 revealed more than 250,000 papers on head and neck cancer; over 100,000 oral 60,000 mouth cancer. Not all publications contain robust evidence. We endeavour to encapsulate the most important of latest information advances now employed practice, a form comprehensible healthcare workers, patients their carers. This series offers primary care dental team, particular, an overview aetiopathogenesis, prevention, diagnosis multidisciplinary cancer, functional...
Delays in the identification and referral of oral cancer remain frequent. An accurate non-invasive diagnostic test to be performed primary care may help identifying at an early stage reduce mortality. Point-of-care Analysis for Non-invasive Diagnosis Oral (PANDORA) was a proof-of-concept prospective accuracy study aimed advancing development dielectrophoresis-based platform squamous cell carcinoma (OSCC) epithelial dysplasia (OED) using novel automated DEPtech 3DEP analyser.The aim PANDORA...