A5002036861- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- COVID-19 and healthcare impacts
- Tracheal and airway disorders
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Voice and Speech Disorders
- Trauma and Emergency Care Studies
- Full-Duplex Wireless Communications
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Nasal Surgery and Airway Studies
- Ear Surgery and Otitis Media
- Subtitles and Audiovisual Media
- Esophageal Cancer Research and Treatment
- Histiocytic Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Research Studies
- Thyroid Cancer Diagnosis and Treatment
- Hearing Loss and Rehabilitation
- RNA modifications and cancer
- Thyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
Cambridge University Hospitals NHS Foundation Trust
2013-2025
AstraZeneca (United Kingdom)
2023-2024
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
University of Cambridge
2013-2022
Addenbrooke's Hospital
2014-2022
Bridge University
2012-2022
Genomics England
2022
University of Liverpool
2021
Hospital Italiano de Buenos Aires
2021
Society of Surgical Oncology
2021
Abstract Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin receptor 2 (SSTR2) expression multiple clinical cohorts comprising 402 primary, locally recurrent metastatic NPCs. We show that SSTR2 induced by Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) via NF-κB pathway. Using cell-based preclinical...
#### The bottom line #### How patients were involved in the creation of this article We sought feedback on paper from patient and medical representatives charity Facial Palsy UK. We incorporated their comments into developed a consultation guide for management prognosis Bell’s palsy (see box below) The facial nerve is important both communication expression, impairment its function can severely affect quality life.1 main concern at first presentation lesion to exclude possibility stroke...
This study was designed to identify significant differences in gene expression profiles of human papillomavirus ( HPV )‐positive and ‐negative oropharyngeal squamous cell carcinomas OPSCC ) better understand the functional biological effects infection premalignant pathway. Twenty‐four consecutive patients with locally advanced primary were included a prospective clinical trial. Fresh tissue samples (tumor vs . matched normal epithelium) subjected whole transcriptome analysis results...
Dear Editor, OPSCC has one of the most rapidly increasing incidences all cancers.1-3 Most cases are associated with HPV infection, which confers improved survival outcomes, compared to HPV-independent disease.4 Despite advancements in understanding HPV-associated OPSCC, role biomarkers like B7-H3 and CEA, both HPV-positive HPV-negative remains unclear. This study addresses this gap by evaluating their expression correlations clinical immune parameters. Additionally, we developed a...
Abstract Objectives: To review our experience of cochlear implant failure and subsequent revision surgery, to illustrate the we have gained by presenting a series lessons learned. Methods: A combined retrospective prospective study surgery in UK regional centre. Results: Of 746 implantations undertaken, 33 (4.7 per cent adults 4.1 children) had registered requiring re-implantation. The mean time device was 60 months 35 children. Causes were medical ( n = 11), electrode displacement 2), ‘hard...
Objective To review the treatment of squamous carcinoma temporal bone at a regional skull base unit for period 1982–2012. Study Design Retrospective case review. Setting Tertiary referral center. Patients Sixty patients with primary bone. Interventions Multidisciplinary team approach including surgical resection, reconstruction, and postoperative radiotherapy. Main Outcome Measures Disease-specific survival, overall survival. Results The 5-year disease-specific survival whole cohort was 44%...
Pleomorphic adenomas are the most common benign tumour of major salivary glands. In addition, they may also occur in minor glands hard and soft palate. Intranasal pleomorphic unusual be misdiagnosed because have greater myoepithelial cellularity fewer myxoid stromata compared to those elsewhere. We present case a 61-year-old man who presented with 2-year history left nasal obstruction, occasional epistaxis facial pain. Radiological examination demonstrated well pneumatised paranasal sinuses...