A5024844105- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Head and Neck Cancer Studies
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Adrenal and Paraganglionic Tumors
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Ear and Head Tumors
- Hormonal Regulation and Hypertension
- Thyroid Cancer Diagnosis and Treatment
University College London Hospitals NHS Foundation Trust
2016-2025
University College London
2016-2025
National Science Center
2025
University College Hospital
2014-2024
Creative Commons
2023
Royal London Hospital
2021
Institute of Nuclear Physics
2013-2020
University of London
2018
National Institute for Health Research
2015-2016
National Heart Centre Singapore
2016
Here we aim to provide updated guidance and standards for the indication, acquisition, interpretation of PSMA PET/CT prostate cancer imaging. Procedures characteristics are reported a variety available small radioligands. Different scenarios clinical use PSMA-ligand discussed. This document provides clinicians technicians with best evidence, support implementation imaging in research routine practice.
Abstract Purpose: We prospectively examined the role of tumor textural heterogeneity on positron emission tomography/computed tomography (PET/CT) in predicting survival compared with other clinical and imaging parameters patients non–small cell lung cancer (NSCLC). Experimental Design: The feasibility study consisted 56 assessed consecutive NSCLC (32 males, 24 females; mean age 67 ± 9.7 years) who underwent combined fluorodeoxyglucose (FDG) PET/CT. validation population 66 recruited...
Cell-based therapies for regeneration of intervertebral discs are regarded to hold promise degenerative disc disease treatment, a condition that is strongly linked lower back pain. A de novo self-assembling peptide hydrogel (SAPH), chosen its biocompatibility, tailorable properties and nanofibrous architecture, was investigated as cell carrier scaffold nucleus pulposus (NP) tissue engineering. Oscillatory rheology determined the system would likely be deliverable via minimally invasive...
Treatment with radioactive drugs (molecular radiotherapy, MRT) is an option for selected children neuroblastoma and neuroendocrine cancers. As few hospitals are appropriately equipped staffed to provide paediatric MRT, many families have travel long distances from home prolonged periods. To improve professional understanding of the challenges faced by receiving these treatments their parents, help them appreciate difficulties professionals in delivering complex treatments, a meeting bringing...
Respiratory motion during PET acquisition may lead to blurring in resulting images and underestimation of uptake parameters. The advent integrated PET/MR scanners allows us exploit the integration modalities, using high spatial resolution high-contrast MR monitor correct degraded by motion. We proposed a practical, anatomy-independent MR-based correction strategy for data affected respiratory showed that it can improve image quality both acquired simultaneously motion-capturing up 1 h...
Background— Hybrid positron emission tomography and magnetic resonance allows the advantages of in tissue characterizing myocardium to be combined with unique metabolic insights tomography. We hypothesized that area reduced myocardial glucose uptake would closely match at risk delineated by T2 mapping ST-segment–elevation infarction patients. Methods Results— using 18 F-fluorodeoxyglucose (FDG) for was performed 21 patients a median 5 days. Follow-up scans were subset 12 months later. The...
Purpose The primary aim was to compare the diagnostic performance of PET/MRI (performed with basic anatomical MRI sequences) in detecting sites disease adult patients lymphoma compared current standard care, PET/CT. Secondary aims were assess additional value diffusion-weighted imaging detection and evaluate relationship between standardized uptake on PET/MR apparent diffusion coefficient imaging. Methods Sixty-eight studies 66 consecutive histologically proven Hodgkin or non-Hodgkin...
Abstract Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin receptor 2 (SSTR2) expression multiple clinical cohorts comprising 402 primary, locally recurrent metastatic NPCs. We show that SSTR2 induced by Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) via NF-κB pathway. Using cell-based preclinical...
Early detection and diagnosis of coronary artery disease could reduce the risk developing a heart attack. The arteries are optimally visualised using computed tomography angiography (CTCA) imaging. These images reviewed by specialist radiologists who evaluate for potential narrowing. A lack in UK is constraint to timely disease, particularly acute accident emergency department setting. development automated methods which narrowing can be identified rapidly accurately therefore timely. Such...
BACKGROUND: A certain proportion of patients with locally advanced rectal cancer experience complete response after undergoing neoadjuvant chemoradiotherapy. These might be suitable for a conservative “watch and wait” approach, avoiding high-morbidity surgery. Texture analysis is new modality that can assess heterogeneity in medical images by statistically analyzing gray-level intensities on pixel-by-pixel basis. This study hypothesizes texture magnetic resonance identify response....
Neuroendocrine tumors (NET) are rare cancers with variable behavior. A better understanding of prognosis would aid individualized management. The aim this hypothesis-generating pilot study was to investigate the prognostic potential tumor heterogeneity and tracer avidity in NET using texture analysis (TA) 68Ga-DOTATATE positron emission tomography (PET) non-enhanced computed (CT) performed at baseline patients treated 177Lu-DOTATATE. It aims justify a larger-scale evaluate its clinical...
Abstract We report a case series of biopsy-proven reactive axillary lymph nodes, which were avid on FDG PET/CT in breast cancer patients post COVID-19 vaccination. With 4 cases presenting consecutive 10-day period, it became apparent that metabolically active lymphadenopathy is an adverse effect vaccines, currently being deployed worldwide. This may lead to undergoing unnecessary biopsy. have started taking vaccine status history before PET/CT. If enlarged/metabolically nodes are identified...
Patient motion due to respiration can lead artefacts and blurring in positron emission tomography (PET) images, addition quantification errors. The integration of PET with magnetic resonance (MR) imaging PET-MR scanners provides complementary clinical information, allows the use high spatial resolution contrast MR images monitor correct motion-corrupted data. In this paper we build on previous work form a methodology for respiratory correction data, show it improve image quality whilst...
To investigate the combined performance of quantitative CT (qCT) following a computer algorithm analysis (IMBIO) and 18F-FDG PET/CT to assess survival in patients with idiopathic pulmonary fibrosis (IPF). A total 113 IPF (age 70 ± 9 years) prospectively consecutively underwent high-resolution (HRCT) at our institution. During mean follow-up 29.6 26 months, 44 (48%) died. As part qCT analysis, pattern evaluation HRCT (using IMBIO software) included extent (percentage) features:...
The emergence of the novel SARS-CoV-2 pathogen and lethal COVID-19 disease pandemic poses major diagnostic challenges. study aims to describe spectrum prevalence thoracic extrathoracic incidental findings in patients who have undergone 18F-FDG PET/CT during first 3 weeks UK lockdown.
Despite improvements in neuroblastoma treatment, survival figures lag behind those of many other childhood malignancies. New treatments, and better use existing are essential to reduce mortality. Neuroblastoma expresses several molecular targets for radionuclide imaging therapy, which the most widely exploited is norepinephrine transporter. [123I]metaiodobenzylguanidine (MIBG) [131I]MIBG target this physiologic pathway, have been clinical practice 40 y. Although therapy outcomes favorable,...
Abstract Purpose Paraganglioma, phaeochromocytoma and gastroenteropancreatic neuroendocrine tumours are rare in childhood. Molecular radiotherapy is one potential treatment for locally inoperable or metastatic disease. This study reviews the use efficacy of molecular with both [ 131 I] meta iodobenzylguanidine (mIBG) 177 Lu] DOTATATE this patient group. Methods an observational cohort all patients aged less than 18 years adult type cancers treated from 2003 to 2023 national referral centre....
<title>Abstract</title> <bold>Objective: </bold>This study compares the clinical benefits of double-tube end ileostomy versus traditional in patients undergoing low anterior resection for rectal cancer. <bold>Methods: </bold>A retrospective analysis was conducted on 65 who underwent laparoscopic radical cancer surgery with preventive between March 2022 and December 2024 at First Affiliated Hospital Anhui Medical University. Of these, 47 received ileostomy, while 18 ileostomy. The...